Proteomics and comparative genomic investigations reveal heterogeneity in evolutionary rate of male reproductive proteins in mice (Mus domesticus).

abstract：:A major topic of interest in human prehistory is how the large-scale genetic structure of modern populations outside of Africa was established. Demographic models have been developed that capture the relationships among small numbers of populations or within particular geographical regions, but constructing a phylogen...

journal_title：Molecular biology and evolution

authors： Lipson M,Reich D

更新日期：2017-04-01 00:00:00

abstract：:A major theoretical consequence of selection at a locus is the genetic hitchhiking of linked sites (selective sweep). The extent of hitchhiking around a gene is related to the strength of selection and the rate of recombination, with its impact diminishing with distance from the selected site. At the Rop-1 locus of th...

journal_title：Molecular biology and evolution

authors： Rose CJ,Chapman JR,Marshall SD,Lee SF,Batterham P,Ross HA,Newcomb RD

更新日期：2011-06-01 00:00:00

abstract：:The SLiM forward genetic simulation framework has proved to be a powerful and flexible tool for population genetic modeling. However, as a complex piece of software with many features that allow simulating a diverse assortment of evolutionary models, its initial learning curve can be difficult. Here we provide a step-...

journal_title：Molecular biology and evolution

authors： Haller BC,Messer PW

更新日期：2019-05-01 00:00:00

abstract：:As the relic of the ancient Champa Kingdom, the Cham people represent the major Austronesian speakers in Mainland Southeast Asia (MSEA) and their origin is evidently associated with the Austronesian diffusion in MSEA. Hitherto, hypotheses stemming mainly from linguistic and cultural viewpoints on the origin of the Cha...

journal_title：Molecular biology and evolution

authors： Peng MS,Quang HH,Dang KP,Trieu AV,Wang HW,Yao YG,Kong QP,Zhang YP

更新日期：2010-10-01 00:00:00

abstract：:Phenotypic plasticity results in a diversity of phenotypes from a single genotype in response to environmental cues. To understand the molecular basis of phenotypic plasticity, studies have focused on differential gene expression levels between environmentally determined phenotypes. The extent of alternative splicing ...

journal_title：Molecular biology and evolution

authors： Grantham ME,Brisson JA

更新日期：2018-08-01 00:00:00

abstract：:Chromosomal DNA from 23 closely related, pathogenic strains of Escherichia coli was digested and probed for the insertion sequences IS1, IS2, IS4, IS5, and IS30. Under the assumption that elements residing in DNA restriction fragments of the same apparent length are identical by descent, parsimony analysis of these ch...

journal_title：Molecular biology and evolution

authors： Lawrence JG,Dykhuizen DE,DuBose RF,Hartl DL

更新日期：1989-01-01 00:00:00

abstract：:The quantitative immunological technique of micro-complement fixation (MC'F) has been routinely used during the past decade to assess evolutionary relationships among living vertebrate species. The large data base that has been generated, along with the excellent correlations between immunologically measured genetic d...

journal_title：Molecular biology and evolution

authors： Maxson RD,Maxson LR

更新日期：1986-09-01 00:00:00

abstract：:Isoprene is the most abundant biogenic volatile hydrocarbon compound naturally emitted by plants and plays a major role in atmospheric chemistry. It has been proposed that isoprene synthases (IspS) may readily evolve from other terpene synthases, but this hypothesis has not been experimentally investigated. We isolate...

journal_title：Molecular biology and evolution

authors： Li M,Xu J,Algarra Alarcon A,Carlin S,Barbaro E,Cappellin L,Velikova V,Vrhovsek U,Loreto F,Varotto C

更新日期：2017-10-01 00:00:00

abstract：:The selective pressure at the protein level is usually measured by the nonsynonymous/synonymous rate ratio (omega = dN/dS), with omega < 1, omega = 1, and omega > 1 indicating purifying (or negative) selection, neutral evolution, and diversifying (or positive) selection, respectively. The omega ratio is commonly calcu...

journal_title：Molecular biology and evolution

authors： Anisimova M,Bielawski JP,Yang Z

更新日期：2001-08-01 00:00:00

abstract：:Cyanobacteria are among the most ancient organisms known to have circadian rhythms. The cpmA gene is involved in controlling the circadian output signal. We studied polymorphism and divergence of this gene in six populations of a stress-tolerant cyanobacterium, Chroococcidiopsis sp., sampled in extreme habitats across...

journal_title：Molecular biology and evolution

authors： Dvornyk V,Jahan AS

更新日期：2012-12-01 00:00:00

abstract：:The structural genes for nitrogenase, nifK, nifD, and nifH, are crucial for nitrogen fixation. Previous phylogenetic analysis of the amino acid sequence of nifH suggested that this gene had been horizontally transferred from a proteobacterium to the gram-positive/cyanobacterial clade, although the confounding effects ...

journal_title：Molecular biology and evolution

authors： Hirsch AM,McKhann HI,Reddy A,Liao J,Fang Y,Marshall CR

更新日期：1995-01-01 00:00:00

abstract：:Here, we present a study of the molecular evolution of the pheromone receptor genes (pre-1 and pre-2) in Neurospora taxa with different mating systems. We focus on comparisons between heterothallic and homothallic taxa, reproducing sexually by outcrossing and by intrahaploid selfing, respectively. Our general aim was ...

journal_title：Molecular biology and evolution

authors： Nygren K,Strandberg R,Gioti A,Karlsson M,Johannesson H

更新日期：2012-12-01 00:00:00

abstract：:Spinocerebellar ataxia type 10 is caused by ATTCT repeat expansion in the ATXN10 gene in humans. We studied the evolutionary history of the human genome to determine the time and mechanism of the acquisition of unstable ATTCT repeats in the genome. We found that long interspersed element-1 (LINE-1) was inserted into A...

journal_title：Molecular biology and evolution

authors： Kurosaki T,Matsuura T,Ohno K,Ueda S

更新日期：2009-11-01 00:00:00

abstract：:An improved understanding of the biological and numerical properties of measures of population differentiation across loci is becoming increasingly more important because of their growing use in analyzing genome-wide polymorphism data for detecting population structures, inferring the rates of migration, and identifyi...

journal_title：Molecular biology and evolution

authors： Maruki T,Kumar S,Kim Y

更新日期：2012-12-01 00:00:00

abstract：:The phylogenies for each of the protein-coding genes from the Methanococcus jannaschii genome were surveyed to determine the history of the major groups of life. For each gene, homologous sequences from other archaea, eucarya, and Gram-positive and Gram-negative bacteria were collected and aligned, and a phylogeny was...

journal_title：Molecular biology and evolution

authors： Ribeiro S,Golding GB

更新日期：1998-07-01 00:00:00

abstract：:Pax genes play key regulatory roles in embryonic and sensory organ development in metazoans but their evolution and ancestral functions remain widely unresolved. We have isolated a Pax gene from Placozoa, beside Porifera the only metazoan phylum that completely lacks nerve and sensory cells or organs. These simplest k...

journal_title：Molecular biology and evolution

authors： Hadrys T,DeSalle R,Sagasser S,Fischer N,Schierwater B

更新日期：2005-07-01 00:00:00

abstract：:The adaptive radiation of cichlid fishes in East African Lake Malawi encompasses over 500 species that are believed to have evolved within the last 800,000 years from a common founder population. It has been proposed that hybridization between ancestral lineages can provide the genetic raw material to fuel such except...

journal_title：Molecular biology and evolution

authors： Svardal H,Quah FX,Malinsky M,Ngatunga BP,Miska EA,Salzburger W,Genner MJ,Turner GF,Durbin R

更新日期：2020-04-01 00:00:00

abstract：:Functional redundancy in genomes arises from genes with overlapping functions, allowing phenotypes to persist after gene knockouts. Evolutionary redundancy or evolvability of a genome is one step removed, in that functional redundancy is absent but the genome has the potential to evolve to restore a lost phenotype. Ex...

journal_title：Molecular biology and evolution

authors： Heineman RH,Bull JJ,Molineux IJ

更新日期：2009-06-01 00:00:00

abstract：:Siberia is one of the coldest environments on Earth and has great seasonal temperature variation. Long-term settlement in northern Siberia undoubtedly required biological adaptation to severe cold stress, dramatic variation in photoperiod, and limited food resources. In addition, recent archeological studies show that...

journal_title：Molecular biology and evolution

authors： Hsieh P,Hallmark B,Watkins J,Karafet TM,Osipova LP,Gutenkunst RN,Hammer MF

更新日期：2017-11-01 00:00:00

abstract：:Chemosensory genes are frequently the target of positive selection and are often present in large gene families, but little is known about heterogeneity of selection in these cases and its relation to function. Here, we use the vomeronasal-1 receptor (V1R) repertoire of mouse lemurs (Microcebus spp.) as a model system...

journal_title：Molecular biology and evolution

authors： Hohenbrink P,Radespiel U,Mundy NI

更新日期：2012-12-01 00:00:00

abstract：:Phenotypic evolution may occur either through alterations to the structure of protein-coding genes or their expression. Evidence for which of these two mechanisms more commonly contribute to the evolution of a phenotype can be garnered from examples of parallel and convergent evolution. The visual system of East Afric...

journal_title：Molecular biology and evolution

authors： O'Quin KE,Hofmann CM,Hofmann HA,Carleton KL

更新日期：2010-12-01 00:00:00

abstract：:Whether coding or regulatory sequence change is more important to the evolution of phenotypic novelty is one of biology's major unresolved questions. The field of evo-devo has shown that in early development changes to regulatory regions are the dominant mode of genetic change, but whether this extends to the evolutio...

journal_title：Molecular biology and evolution

authors： Jasper WC,Linksvayer TA,Atallah J,Friedman D,Chiu JC,Johnson BR

更新日期：2015-02-01 00:00:00

abstract：:Plasmodium vivax in southern Mexico exhibits different infectivities to 2 local mosquito vectors, Anopheles pseudopunctipennis and Anopheles albimanus. Previous work has tied these differences in mosquito infectivity to variation in the central repeat motif of the malaria parasite's circumsporozoite (csp) gene, but su...

journal_title：Molecular biology and evolution

authors： Joy DA,Gonzalez-Ceron L,Carlton JM,Gueye A,Fay M,McCutchan TF,Su XZ

更新日期：2008-06-01 00:00:00

abstract：:Analyses of diverse eukaryotes reveal that genomes are dynamic, sometimes dramatically so. In numerous lineages across the eukaryotic tree of life, DNA content varies within individuals throughout life cycles and among individuals within species. Discovery of examples of genome dynamism is accelerating as genome seque...

journal_title：Molecular biology and evolution

authors： Parfrey LW,Lahr DJ,Katz LA

更新日期：2008-04-01 00:00:00

abstract：:Remarkably little is known about the population-level processes leading up to the extinction of the neandertal. To examine this, we use mitochondrial DNA sequences from 13 neandertal individuals, including a novel sequence from northern Spain, to examine neandertal demographic history. Our analyses indicate that recen...

journal_title：Molecular biology and evolution

authors： Dalén L,Orlando L,Shapiro B,Brandström-Durling M,Quam R,Gilbert MT,Díez Fernández-Lomana JC,Willerslev E,Arsuaga JL,Götherström A

更新日期：2012-08-01 00:00:00

abstract：:We show how to make appropriate likelihood ratio tests for evolutionary tree models when parameters such as edge (internodes or branches) lengths have nonnegativity constraints. In such cases, under the null model of an edge length being zero, the marginal distribution of this parameter is proven to be a "half-normal"...

journal_title：Molecular biology and evolution

authors： Ota R,Waddell PJ,Hasegawa M,Shimodaira H,Kishino H

更新日期：2000-05-01 00:00:00

abstract：:Males and females often have marked phenotypic differences, and the expression of these dissimilarities invariably involves sex differences in gene expression. Sex-biased gene expression has been well characterized in animal species, where a high proportion of the genome may be differentially regulated in males and fe...

journal_title：Molecular biology and evolution

authors： Lipinska A,Cormier A,Luthringer R,Peters AF,Corre E,Gachon CM,Cock JM,Coelho SM

更新日期：2015-06-01 00:00:00

abstract：:The capacity to biomineralize is closely linked to the rapid expansion of animal life during the early Cambrian, with many skeletonized phyla first appearing in the fossil record at this time. The appearance of disparate molluscan forms during this period leaves open the possibility that shells evolved independently a...

journal_title：Molecular biology and evolution

authors： Jackson DJ,McDougall C,Woodcroft B,Moase P,Rose RA,Kube M,Reinhardt R,Rokhsar DS,Montagnani C,Joubert C,Piquemal D,Degnan BM

更新日期：2010-03-01 00:00:00

abstract：:Despite the general assumption that site-specific mutation rates are independent of the local sequence context, a growing body of evidence suggests otherwise. To further examine context-dependent patterns of mutation, we amassed 5,645 spontaneous mutations in wild- type (WT) and mismatch-repair deficient (MMR(-)) muta...

journal_title：Molecular biology and evolution

authors： Sung W,Ackerman MS,Gout JF,Miller SF,Williams E,Foster PL,Lynch M

更新日期：2015-07-01 00:00:00

abstract：:The increased interest in asexual organisms calls for in-depth studies of asexual complexes that actively give rise to new clones. We present an extensive molecular study of the Otiorhynchus scaber (Coleoptera, Curculionidae) weevil system. Three forms have traditionally been recognized: diploid sexuals, triploid, and...

journal_title：Molecular biology and evolution

authors： Stenberg P,Lundmark M,Knutelski S,Saura A

更新日期：2003-10-01 00:00:00