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Advanced/metastatic bladder cancer: current status and future directions.

Abstract：

:In 2015 bladder cancer was the fourth most frequent malignancy and the eighth cause of death for cancer. At diagnosis, about 30% of bladder cancer (BC) patients present a muscle-invasive bladder cancer (MIBC) and 5% a metastatic bladder carcinoma (MBC). For fit MBC patients, combination chemotherapy (CC) is the standard of care for first-line treatment. CC includes both the treatment with methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) either the classical or the dose-dense MVAC regimen, and the doublet therapy with cisplatin and gemcitabine (CG). Median progression free survival (PFS) was 7 months and median overall survival (OS) was 15 months. The present review provides an update on the management of MBC, with focus on target therapies, immune checkpoint inhibition, looking for prognostic and predictive factors.

journal_name

Eur Rev Med Pharmacol Sci

journal_title

European review for medical and pharmacological sciences

authors

Facchini G,Cavaliere C,Romis L,Mordente S,Facchini S,Iovane G,Capasso M,D'Errico D,Liguori C,Formato R,Cicala S,Andreozzi F,Di Lauro G,Imbimbo C,Vanni M,D'Aniello C

doi

10.26355/eurrev_202011_23795

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

11536-11552

issue

22

eissn

1128-3602

issn

2284-0729

journal_volume

24

pub_type

杂志文章

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