Abstract:
:Continuous high-risk (HR) human papillomavirus (HPV) infection is an essential factor for cervical carcinoma and its precancerous lesions. There are differences in HPV distribution among different countries, regions and ethnic groups. The aim of this research was to reveal the epidemiological characteristics of HPV in Chongqing, China. Twenty-three HPV genotypes of 13788 women aged 18 to 78 were screened by PCR-reverse dot blot hybridization. The total HPV-positive rate was 19.9% (2745/13788), while the positive rates of HR, and low-risk (LR) HPV were 17.3% (2379/13788), and 4.6% (638/13788), respectively. In addition to cervical cancer (CC) and cervical intraepithelial neoplasia (CIN) patients, the HPV infection rates of infertile women and women with gynecological diseases were markedly higher than those of healthy people. The HPV and HR-HPV infection rates in the different age groups showed statistically significant differences, and the prevalence peaks appeared in women under 20 years and over 50 years of age. HPV-52, HPV-16 and HPV-58 ranked as the top 3 most common subtypes among women in Chongqing. The results of this research provide epidemiological information on HPV infection in Chongqing. These data constitute valuable evidence for the prevention and management of cervical carcinoma and the development of HPV vaccines.
journal_name
Jpn J Infect Disjournal_title
Japanese journal of infectious diseasesauthors
Yan L,Yang J,Long X,Zhou Ddoi
10.7883/yoken.JJID.2020.635subject
Has Abstractpub_date
2020-11-30 00:00:00eissn
1344-6304issn
1884-2836pub_type
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