Reduced Remodeling Biomarkers Tissue Expression in Nanotextured Compared with Polyurethane Implants Capsules: A Study in Rats.

Abstract:

BACKGROUND:In the biological response to biomaterials, implant shell play a key role in immune and inflammatory reactions. Our hypothesis is that the capsules formed around nanotextured implants exhibit an immunohistochemical behavior different from those formed around polyurethane implants. OBJECTIVES:Evaluate through immunohistochemistry markers the capsules formed around nanotextured and polyurethane implants. METHODS:Sixty albino female Wistar rats were divided into two groups (nanotextured and polyurethane), with 30 animals in each group. A mini silicone implant was inserted on the back of the animals. After the determined period, the animals were euthanized, and the capsules formed around the implants were studied. The capsules in the 30-, 60- and 90-day subgroups were analyzed via immunohistochemistry to detect α-SMA, TGF-β, CD34 and CD68 markers, via picrosirius staining to determine the density of type I and III collagen fibers and via hematoxylin and eosin staining to assess capsule thickness. A Wilcoxon-Mann-Whitney test was used to compare the groups, and a Kruskal-Wallis test was used to compare the subgroups. RESULTS:Lower α-SMA, TGF-β, CD34 and CD68 immunoexpression was observed in the nanotextured 30- and 60-day subgroups than in the corresponding polyurethane subgroups. In the 90-day subgroup, more pronounced α-SMA and CD34 immunoexpression was observed in the nanotextured group; however, TGF-β and CD68 immunoexpression remained lower. The nanotextured implants had reduced capsular thickness and greater formation of type I collagen in all the analyzed subgroups. CONCLUSIONS:Nanotextured implants led to reduced immune and inflammatory reactions compared with polyurethane implants according to all analyzed variables.

journal_name

Aesthet Surg J

authors

Pontes GH,Vargas Guerrero LA,Mendes Carneiro Filho FS,Lipinski LC,de Noronha L,Silva EN,Serra-Guimarães F

doi

10.1093/asj/sjaa315

subject

Has Abstract

pub_date

2020-11-24 00:00:00

eissn

1090-820X

issn

1527-330X

pii

6000096

pub_type

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