Fat grafting to the breast and adipose-derived stem cells: recent scientific consensus and controversy.

Abstract:

:Recent technical advances in fat grafting and the development of surgical devices such as liposuction cannulae have made fat grafting a relatively safe and effective procedure. However, new guidelines issued by the American Society of Plastic Surgeons in 2009 announced that fat grafting to the breast is not a strongly recommended procedure, as there are limited scientific data on the safety and efficacy of this particular type of fat transfer. Recent progress by several groups has revealed that multipotent adult stem cells are present in human adipose tissue. This cell population, termed adipose-derived stem cells (ADSC), represents a promising approach to future cell-based therapies, such as tissue engineering and regeneration. In fact, several reports have shown that ADSC play a pivotal role in graft survival through both adipogenesis and angiogenesis. Although tissue augmentation by fat grafting does have several advantages in that it is a noninvasive procedure and results in minimal scarring, it is essential that such a procedure be supported by evidence-based medicine and that further basic scientific and clinical research is conducted to ensure that fat grafting is a safe and effective procedure.

journal_name

Aesthet Surg J

authors

Mizuno H,Hyakusoku H

doi

10.1177/1090820X10373063

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

381-7

issue

3

eissn

1090-820X

issn

1527-330X

pii

30/3/381

journal_volume

30

pub_type

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