Phase II study of ifosfamide, carboplatin, and etoposide in patients with a first recurrence of glioblastoma multiforme.

Abstract:

OBJECT:The prognosis of recurrent glioblastoma multiforme (GBM) remains unsatisfactory. The authors conducted a Phase II study of ifosfamide, carboplatin, and etoposide (ICE) for a first recurrence of GBM to determine whether it prolonged a patient's good-quality life. METHODS:This trial was an open-label, single-center Phase II study. Forty-two patients with a first GBM relapse after surgery followed by standard radiotherapy (60 Gy) and first-line temozolomide- or nimustine-based chemotherapy were eligible to participate. The primary end point was progression-free survival at 6 months after the ICE treatment (PFS-6), and secondary end points were response rate, toxicity, and overall survival. Chemotherapy consisted of ifosfamide (1000 mg/m(2) on Days 1, 2, and 3), carboplatin (110 mg/m(2) on Day 1), etoposide (100 mg/m(2) on Days 1, 2, and 3), every 6 weeks. RESULTS:Progression-free survival at 6 months after ICE treatment was 35% (95% CI 22-50%). The median duration of PFS was 17 weeks (95% CI 10-24 weeks). The response rate was 25% (95% CI 9-34%). Adverse events were generally mild and consisted mainly of alopecia. CONCLUSIONS:This regimen was well tolerated and has some activity and could be one of the options for patients with recurrent GBM.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Aoki T,Mizutani T,Nojima K,Takagi T,Okumura R,Yuba Y,Ueba T,Takahashi JA,Miyatake S,Nozaki K,Taki W,Matsutani M

doi

10.3171/2009.5.JNS081738

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

50-6

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

112

pub_type

杂志文章
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  • Intracranial pressure monitoring in pediatric and adult patients with hydrocephalus and tentative shunt failure: a single-center experience over 10 years in 146 patients.

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  • Inhibition of delayed arterial narrowing by the iron-chelating agent deferoxamine.

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  • Single-beam radiotherapy knife. A practical theoretical model.

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  • Ganglioglioma of the brain stem. Case report.

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    authors: Garcia CA,McGarry PA,Collada M

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    pub_type: 杂志文章

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  • Cytochemical demonstration of adenylate and guanylate cyclases in vascular smooth muscle of circle of Willis.

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  • Radiosurgery for trigeminal neuralgia: is sensory disturbance required for pain relief?

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