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Unintended consequences of infection prevention and control measures during COVID-19 pandemic.

Abstract：

BACKGROUND:In the current COVID-19 pandemic, aggressive Infection Prevention and Control (IPC) measures have been adopted to prevent health care-associated transmission of COVID-19. We evaluated the impact of a multimodal IPC strategy originally designed for the containment of COVID-19 on the rates of other hospital-acquired-infections (HAIs). METHODOLOGY:From February-August 2020, a multimodal IPC strategy was implemented across a large health care campus in Singapore, comprising improved segregation of patients with respiratory symptoms, universal masking and heightened adherence to Standard Precautions. The following rates of HAI were compared pre- and postpandemic: health care-associated respiratory-viral-infection (HA-RVI), methicillin-resistant Staphylococcus aureus, and CP-CRE acquisition rates, health care-facility-associated C difficile infections and device-associated HAIs. RESULTS:Enhanced IPC measures introduced to contain COVID-19 had the unintended positive consequence of containing HA-RVI. The cumulative incidence of HA-RVI decreased from 9.69 cases per 10,000 patient-days to 0.83 cases per 10,000 patient-days (incidence-rate-ratio = 0.08; 95% confidence interval [CI] = 0.05-0.13, P< .05). Hospital-wide MRSA acquisition rates declined significantly during the pandemic (incidence-rate-ratio = 0.54, 95% CI = 0.46-0.64, P< .05), together with central-line-associated-bloodstream infection rates (incidence-rate-ratio = 0.24, 95% CI = 0.07-0.57, P< .05); likely due to increased compliance with Standard Precautions. Despite the disruption caused by the pandemic, there was no increase in CP-CRE acquisition, and rates of other HAIs remained stable. CONCLUSIONS:Multimodal IPC strategies can be implemented at scale to successfully mitigate health care-associated transmission of RVIs. Good adherence to personal-protective-equipment and hand hygiene kept other HAI rates stable even during an ongoing pandemic where respiratory infections were prioritized for interventions.

journal_name

Am J Infect Control

journal_title

American journal of infection control

authors

Wee LEI,Conceicao EP,Tan JY,Magesparan KD,Amin IBM,Ismail BBS,Toh HX,Jin P,Zhang J,Wee EGL,Ong SJM,Lee GLX,Wang AE,How MKB,Tan KY,Lee LC,Phoon PC,Yang Y,Aung MK,Sim XYJ,Venkatachalam I,Ling ML

doi

10.1016/j.ajic.2020.10.019

subject

Has Abstract

pub_date

2020-11-04 00:00:00

eissn

0196-6553

issn

1527-3296

pii

S0196-6553(20)30963-9

pub_type

杂志文章

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Unintended consequences of infection prevention and control measures during COVID-19 pandemic.