Abstract：
OBJECTIVES:To identify patient groups associated with a high probability of false positives in photodynamic diagnosis (PDD) of bladder cancer for which the use of highly specific optical instruments could be beneficial. METHODS:This study includes the data of 306 patients. Under white light and 5-aminolevulinic acid-induced fluorescence light guidance, tumor locations were recorded, cold-cup biopsies were taken and tumors resected. Age, gender, recent transurethral resection of bladder tumor (TURBT), previous intravesical therapy, and urinary tract infections were examined for association with the false-positive rates in fluorescence cystoscopy by performing a multivariate analysis. RESULTS:Significant univariate associations were found between false positives and gender (P = .009, odds ratio [OR] = 0.51), previous intravesical therapy (P = .03, OR = 1.78), previous BCG instillations (P = .03, OR = 2.05), and TURBT in the past 90 days (P = .01, OR = 2.37). In the multivariate regression model, female gender (male; P = .005, OR = 0.41) and TURBT within 90 days before PDD (P = .01, OR = 2.38) are significant independent predictors of false-positive findings in PDD. CONCLUSIONS:Recent TURBTs and female gender are significant independent predictors of false positives in fluorescence cystoscopy.
journal_name
Urologyjournal_title
Urologyauthors
Draga RO,Grimbergen MC,Kok ET,Jonges TN,Bosch JLdoi
10.1016/j.urology.2009.04.095subject
Has Abstractpub_date
2009-10-01 00:00:00pages
851-6issue
4eissn
0090-4295issn
1527-9995pii
S0090-4295(09)00801-2journal_volume
74pub_type
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