Abstract:
:The affect-modulated acoustic startle response (ASR) might be a promising indicator for emotional reactivity as an endophenotype (an intermediate level between genetics and phenotypes), which we expected to be associated with the DRD4 polymorphism. Therefore, the affect-modulated ASR was examined in 114 healthy volunteers, 74 lacking the DRD4 7R allele (7R-absent group) and 41 with at least one DRD4 7R allele (7R group). Results revealed the well-known affect-modulated ASR in the 7R-absent group. The 7R group, however, was characterized by a blunted affect-modulated ASR, especially by a reduced startle potentiation toward unpleasant pictures. Associations between the exploratory assessed 5-HTT, COMT, and DAT polymorphisms and affect-modulated ASR were not found. Results speak for the importance of the DRD4 polymorphism in modulating emotional responses and also for the usefulness of the affect-modulated ASR as an endophenotype.
journal_name
Psychophysiologyjournal_title
Psychophysiologyauthors
Pauli P,Conzelmann A,Mucha RF,Weyers P,Baehne CG,Fallgatter AJ,Jacob CP,Lesch KPdoi
10.1111/j.1469-8986.2009.00923.xsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
25-33issue
1eissn
0048-5772issn
1540-5958pii
PSYP923journal_volume
47pub_type
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