Intracellular free magnesium of brain and cerebral phosphorus-containing metabolites after subarachnoid hemorrhage and hypermagnesemic treatment: a ³¹P–magnetic resonance spectroscopy study. Clinical article.

Abstract:

OBJECT:Disturbance of cerebral phosphorus-containing metabolites occurs in many disease entities and has not been widely studied in patients with subarachnoid hemorrhage (SAH). Pilot studies have indicated that hypermagnesemic treatment may improve outcome in patients with aneurysmal SAH, but the precise mechanism is not known. The authors hypothesized that, by raising intracellular brain free magnesium in aneurysmal SAH, hypermagnesemic treatment would alter the cerebral energy status. METHODS:The authors designed the current study to use ³¹P-MR spectroscopy (MRS) to investigate intracellular brain free magnesium and cerebral phosphorus-containing metabolites in patients with good-grade aneurysmal SAH, both those receiving and not receiving hypermagnesemic therapy. A total of 37 eligible patients and 23 healthy volunteers were recruited. A total of 81 MRS studies were performed. RESULTS:Hypermagnesemic treatment after aneurysmal SAH produced a small (mean difference 0.018 ± 0.007 mM [+ 13.0%]) but significant elevation of intracellular free magnesium during the 1st week. Aneurysmal SAH produced a depressed membrane metabolism with lower phosphodiester/total phosphate. CONCLUSIONS:The MRS finding of elevated brain free intracellular magnesium after intravenous magnesium sulfate infusion is novel, and the changes in membrane metabolism provide insight into the metabolic effects of aneurysmal SAH and future pathophysiological studies.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Wong GK,Yeung DK,Ahuja AT,King AD,Lam CW,Chan MT,Gin T,Poon WS

doi

10.3171/2009.10.JNS09915

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

763-9

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

113

pub_type

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