Tremor cells in the human thalamus: differences among neurological disorders.


OBJECT:Thalamic neurons firing at frequencies synchronous with tremor are thought to play a critical role in the generation and maintenance of tremor. The authors studied the incidence and locations of neurons with tremor-related activity (TRA) in the thalamus of patients with varied pathological conditions-including Parkinson disease (PD), essential tremor (ET), multiple sclerosis (MS), and cerebellar disorders--to determine whether known differences in the effectiveness of thalamic stereotactic procedures for these tremors could be correlated to differences in the incidence or locations of TRA cells. METHODS:Seventy-five operations were performed in 61 patients during which 686 TRA cells were recorded from 440 microelectrode trajectories in the thalamus. The locations of the TRA cells in relation to electrophysiologically defined thalamic nuclei and the commissural coordinates were compared among patient groups. The authors found that TRA cells are present in patients with each of these disorders and that these cells populate several nuclei in the ventral lateral tier of the thalamus. There were no large differences in the locations of TRA cells among the different diagnostic classes, although there was a difference in the incidence of TRA cells in patients with PD, who had greater than 3.8 times more cells per thalamic trajectory than patients with ET and approximately five times more cells than patients with MS or cerebellar disorders. CONCLUSIONS:There was an increased incidence of TRA in the thalamus of patients with PD. The location of thalamic TRA cells in patients with basal ganglia and other tremor disorders was similar.


J Neurosurg


Journal of neurosurgery


Brodkey JA,Tasker RR,Hamani C,McAndrews MP,Dostrovsky JO,Lozano AM




Has Abstract


2004-07-01 00:00:00












  • Mycotic aneurysms of the internal carotid artery. Case report.

    abstract::The authors report a case with two mycotic aneurysms in the cavernous portion of the internal carotid artery, presumably secondary to a transient bacteremia from pneumonia. The strikingly rapid development of the aneurysms was demonstrated by angiography. Painful total ophthalmoplegia and extophthalmos were the main c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Shibuya S,Igarashi S,Amo T,Sato H,Fukumitsu T

    更新日期:1976-01-01 00:00:00

  • Management and outcome of hemorrhage after Gamma Knife surgery for arteriovenous malformations of the brain.

    abstract:OBJECT:Appropriate management of hemorrhage after Gamma Knife surgery (GKS) for arteriovenous malformations (AVMs) of the brain is poorly understood, although a certain proportion of patients suffer from hemorrhage. METHODS:Among 500 patients observed for 1 to 183 months (median 70 months) after GKS, 32 patients (6.4%...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Maruyama K,Shin M,Tago M,Kurita H,Kawahara N,Morita A,Saito N

    更新日期:2006-12-01 00:00:00

  • Use of the h index in neurosurgery. Clinical article.

    abstract:OBJECT:Assessing academic productivity through simple quantification may overlook key information, and the use of statistical enumeration of academic output is growing. The h index, which incorporates both the total number of publications and the citations of those publications, has been recently proposed as an objecti...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Lee J,Kraus KL,Couldwell WT

    更新日期:2009-08-01 00:00:00

  • Analysis of intra- and intercellular calcium signaling in a mouse malignant glioma cell line.

    abstract::Intra- and intercellular calcium signaling in glioma cells was examined by mechanical stimulation of a monolayer cell line of methylcholanthrene-induced mouse ependymoblastoma, 203-glioma, with a fine round-tip glass needle. A fura-2 fluorescence image of the glioma revealed a four- to eightfold increase in the cytoso...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yamasaki T,Enomoto K,Moritake K,Maeno T

    更新日期:1994-09-01 00:00:00

  • Chronic spinal subdural hematomas. Report of two cases.

    abstract::Two patients with chronic spinal subdural hematomas are described. Both had a fluctuating clinical course, not previously documented in the literature. Surgical evacuation resulted in almost complete recovery. The pathogenesis of spinal subdural hematoma is discussed and the pertinent literature is reviewed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Khosla VK,Kak VK,Mathuriya SN

    更新日期:1985-10-01 00:00:00

  • Subthalamic nucleus stimulation for Parkinson disease: benefits observed in levodopa-intolerant patients.

    abstract:OBJECT:A blinded evaluation of the effects of subthalamic nucleus (STN) stimulation was performed in levodopa-intolerant patients with Parkinson disease (PD). These patients (Group I, seven patients) were moderately or severely disabled (Hoehn and Yahr Stages III-V during the off period), but were receiving only a smal...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Katayama Y,Kasai M,Oshima H,Fukaya C,Yamamoto T,Ogawa K,Mizutani T

    更新日期:2001-08-01 00:00:00

  • Treatment of moyamoya disease with STA-MCA anastomosis.

    abstract::Moyamoya disease is a chronic occlusive cerebrovascular disease of unknown etiology for which no effective treatment has been found. The authors report the result of 23 superficial temporal-middle cerebral artery (STA-MCA) anastomoses and seven encephalomyosynangioses, performed on 13 cases with moyamoya disease and o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Karasawa J,Kikuchi H,Furuse S,Kawamura J,Sakaki T

    更新日期:1978-11-01 00:00:00

  • Validation of transcranial Doppler ultrasound with a stereotactic neurosurgical technique.

    abstract::Vessel identification during a transcranial Doppler (TCD) ultrasound examination is usually based on well-established inferential criteria without confirmation by imaging. Part of a routine study involves taking measurements from the M1 segment of the middle cerebral artery (MCA) and the A1 segment of the anterior cer...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Monsein LH,Razumovsky AY,Ackerman SJ,Nauta HJ,Hanley DF

    更新日期:1995-06-01 00:00:00

  • Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors.

    abstract:OBJECT:The objective of the present study was to perform a prospective evaluation of the potential efficacy and safety of intraoperative photodynamic therapy (PDT) using talaporfin sodium and irradiation using a 664-nm semiconductor laser in patients with primary malignant parenchymal brain tumors. METHODS:In 27 patie...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究


    authors: Muragaki Y,Akimoto J,Maruyama T,Iseki H,Ikuta S,Nitta M,Maebayashi K,Saito T,Okada Y,Kaneko S,Matsumura A,Kuroiwa T,Karasawa K,Nakazato Y,Kayama T

    更新日期:2013-10-01 00:00:00

  • Pontine encephalocele and abnormalities of the posterior fossa following transclival endoscopic endonasal surgery.

    abstract:OBJECT:Transclival endoscopic endonasal surgery (EES) has recently been used for the treatment of posterior fossa tumors. The optimal method of reconstruction of large clival defects following EES has not been established. METHODS:A morphometric analysis of the posterior fossa was performed in patients who underwent t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Koutourousiou M,Filho FV,Costacou T,Fernandez-Miranda JC,Wang EW,Snyderman CH,Rothfus WE,Gardner PA

    更新日期:2014-08-01 00:00:00

  • Unusual case of extradural choroid plexus papilloma of the sacral canal. Case report.

    abstract::An unusual case of a sacral, extradural choroid plexus papilloma involving the S1-3 level is described. This 50-year-old woman presented with a 4-month history of pain involving her right buttock, perineum, and leg. Contrast-enhanced magnetic resonance (MR) imaging of the spine revealed a well-defined, mildly enhancin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kurtkaya-Yapicier O,Scheithauer BW,Van Peteghem KP,Sawicki JE

    更新日期:2002-07-01 00:00:00

  • Spinal cord injury without radiological abnormality in preschool-aged children: correlation of magnetic resonance imaging findings with neurological outcomes.

    abstract:OBJECT:Spinal cord injury without radiological abnormality (SCIWORA) was defined in the era when magnetic resonance (MR) images were not popularly used as diagnostic tools. Although it is generally accepted that MR imaging can effectively illustrate the level and severity of spinal cord injury in the acute phase of tra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Liao CC,Lui TN,Chen LR,Chuang CC,Huang YC

    更新日期:2005-07-01 00:00:00

  • Analysis and measurement of some sources of variability in experimental spinal cord trauma.

    abstract::Experiments were performed on anesthetized cats to determine whether the variability that is common in experimental spinal cord injuries produced by the weight-drop technique can be reduced if a more accurate determination of the actual intensity of the insult to the cord is measured. In addition, determinations of th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Molt JT,Nelson LR,Poulos DA,Bourke RS

    更新日期:1979-06-01 00:00:00

  • Indications for surgical treatment of intracerebral hemorrhage.

    abstract::The authors report a series of 71 patients with intracerebral hemorrhage: 57 underwent surgery and 14, although suitable candidates for surgery, refused operation. The results are assessed in relation to the site of the hemorrhage, mode of onset, and interval between accident and operation. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tedeschi G,Bernini FP,Cerillo A

    更新日期:1975-11-01 00:00:00

  • Transparaspinal exposure of dumbbell tumors of the spine. Report of two cases.

    abstract::The authors present a surgical technique for resection of dumbbell tumors of the spine. The transparaspinal exposure combines laminectomy and sectioning of the paraspinal muscles through a transverse incision. The procedure allows total tumor resection by means of a single posterior approach in selected patients, thus...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Onesti ST,Ashkenazi E,Michelsen WJ

    更新日期:1998-01-01 00:00:00

  • Ectopic intracavernous sinus adrenocorticotropic hormone-secreting microadenoma: could this be a common cause of failed transsphenoidal surgery in Cushing disease? Case report.

    abstract::Despite diagnostic advances, it remains difficult to identify intrasellar and ectopic parasellar adrenocorticotropic hormone (ACTH)-secreting microadenomas. The authors present the case of a 61-year-old woman with Cushing disease in whom a significant central-to-peripheral and lateralized right-sided ACTH gradient was...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kim LJ,Klopfenstein JD,Cheng M,Nagul M,Coons S,Fredenberg C,Brachman DG,White WL

    更新日期:2003-06-01 00:00:00

  • Hypoglossal-facial nerve side-to-end anastomosis for preservation of hypoglossal function: results of delayed treatment with a new technique.

    abstract::This report describes a new surgical technique to improve the results of conventional hypoglossal-facial nerve anastomosis that does not necessitate the use of nerve grafts or hemihypoglossal nerve splitting. Using this technique, the mastoid process is partially resected to open the stylomastoid foramen and the desce...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sawamura Y,Abe H

    更新日期:1997-02-01 00:00:00

  • Combining endovascular and neurosurgical treatments of high-risk dural arteriovenous fistulas in the lateral sinus and the confluence of the sinuses.

    abstract:OBJECT:The authors describe the use of a systemic approach to treat dural arteriovenous fistulas (DAVFs) in the lateral sinus and the confluence of sinuses in 17 patients who presented with signs and symptoms related to intracranial hemorrhage, infarction, and diffuse brain swelling. METHODS:Angiographic examination r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Goto K,Sidipratomo P,Ogata N,Inoue T,Matsuno H

    更新日期:1999-02-01 00:00:00

  • Impact of cerebral blood flow changes due to arterial bypass surgery on cognitive function in adult patients with symptomatic ischemic moyamoya disease.

    abstract:OBJECTIVE:Some adult patients with moyamoya disease (MMD) undergoing revascularization surgery show an improvement or decline in cognition postoperatively. Revascularization surgery for ischemic MMD augments cerebral blood flow (CBF) and improves cerebral oxygen metabolism. However, cerebral hyperperfusion, which is a ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yanagihara W,Chida K,Kobayashi M,Kubo Y,Yoshida K,Terasaki K,Ogasawara K

    更新日期:2018-12-14 00:00:00

  • Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients.

    abstract:OBJECT:The authors reviewed their experience with endoscopic approaches to determine their safety and efficacy in the treatment of pediatric patients who harbor skull base lesions. Although they were interested in ascertaining outcomes after surgery as well as validating and defining indications and limitations of thes...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kassam A,Thomas AJ,Snyderman C,Carrau R,Gardner P,Mintz A,Kanaan H,Horowitz M,Pollack IF

    更新日期:2007-02-01 00:00:00

  • Fracture of S1-2 after L4-S1 decompression and fusion. Case report and review of the literature.

    abstract::The author describes a woman in whom an S1-2 fracture developed after L4-S1 decompression and fusion. Osteoporosis was not present, but the lesion failed to respond to conservative therapy, necessitating surgical extension of the spinal fusion. Although biomechanical complications of lumbosacral fusion are uncommon, p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Bose B

    更新日期:2003-10-01 00:00:00

  • Adult rhombencephalosynapsis. Case report.

    abstract::Rhombencephalosynapsis (RS) is a relatively rare developmental disorder of the cerebellum in which the cerebellar hemispheres are fused across the midline without being separated by a cleft or the vermis. The condition may be associated with hydrocephalus and other intracranial and extracranial abnormalities. The auth...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Guyot LL,Kazmierczak CD,Michael DB

    更新日期:2000-08-01 00:00:00

  • Surgical implications of the thickened pituitary stalk accompanied by central diabetes insipidus.

    abstract:OBJECT:The authors discuss the indications for and timing of a diagnostic neurosurgical procedure in children with diabetes insipidus (DI) and a thickened pituitary stalk (TPS) on magnetic resonance (MR) imaging. METHODS:Seven children with a TPS who presented with DI eventually underwent surgery for diagnostic purpos...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Beni-Adani L,Sainte-Rose C,Zerah M,Brunelle F,Constantini S,Renier D,Lellouch-Tubiana A,Leger J,Pierre-Kahn A

    更新日期:2005-08-01 00:00:00

  • The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma.

    abstract:OBJECT:Nuclear receptor corepressor (N-CoR) forms a complex that maintains neural stem cells in an undifferentiated state through transcriptional repression. Recently, it has been shown that N-CoR is overexpressed in glioblastoma multiforme (GBM) tumor stem cells and has a putative role in maintaining these cells in an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Lu J,Zhuang Z,Song DK,Mehta GU,Ikejiri B,Mushlin H,Park DM,Lonser RR

    更新日期:2010-08-01 00:00:00

  • Placental alkaline phosphatase as a tumor marker for primary intracranial germinoma.

    abstract::A sensitive enzyme-linked immunosorbent assay (ELISA) was used in a retrospective study of placental alkaline phosphatase (PLAP) levels in serum, cerebrospinal fluid (CSF), and intratumoral cyst fluid in primary intracranial germinoma. The ELISA showed no cross-reactivity with intestinal alkaline phosphatase except in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Shinoda J,Yamada H,Sakai N,Ando T,Hirata T,Miwa Y

    更新日期:1988-05-01 00:00:00

  • The surgical correction of coronal and metopic craniosynostoses.

    abstract::Procedures for relief of coronal synostosis and metopic synostosis have resulted in some undesirable sequelae. The authors present combined neurological and plastic surgical modifications to prevent additional synostoses, forehead ridging, and lateral orbital wall step-off. They recommend bifrontal craniotomy with lat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Marsh JL,Schwartz HG

    更新日期:1983-08-01 00:00:00

  • A flow-regulating device to control differential pressure in CSF shunt systems. Technical note.

    abstract::A method of regulating flow rate through cerebrospinal fluid (CSF) shunts with the addition of a flow-regulating device (FRD) is reported. The FRD consists of a small-caliber (0.4 mm) Teflon tube placed in the usual connector. This device has the advantage of converting the original shunt valves to valves for higher-r...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yamada H

    更新日期:1982-10-01 00:00:00

  • Systems analysis of cerebrovascular pressure transmission: an observational study in head-injured patients.

    abstract::In an observational study in head-injured patients, cerebrovascular pressure transmission was investigated using a systems analysis approach whereby the blood pressure (BP) waveform was used as a measure of an input stimulus to the cerebrovascular bed (CVB) and the intracranial pressure (ICP) waveform as the response ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审


    authors: Piper IR,Miller JD,Dearden NM,Leggate JR,Robertson I

    更新日期:1990-12-01 00:00:00

  • Postirradiation sarcomatous transformation of a pituitary adenoma: a combined pituitary tumor. Case report.

    abstract::A case is reported in which a fibrosarcoma developed 20 years after irradiation of a pituitary chromophobe adenoma. This rare lesion, like most of the other documented postirradiation pituitary sarcomas, was a combination of fibrosarcoma and pituitary adenoma. These lesions tend to behave in a characteristic fashion, ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pieterse S,Dinning TA,Blumbergs PC

    更新日期:1982-02-01 00:00:00

  • Vision of the future: initial experience with intraoperative real-time high-resolution dynamic infrared imaging. Technical note.

    abstract::High-resolution dynamic infrared (DIR) imaging provides intraoperative real-time physiological, anatomical, and pathological information; however, DIR imaging has rarely been used in neurosurgical patients. The authors report on their initial experience with intraoperative DIR imaging in 30 such patients. A novel, lon...

    journal_title:Journal of neurosurgery



    authors: Ecker RD,Goerss SJ,Meyer FB,Cohen-Gadol AA,Britton JW,Levine JA

    更新日期:2002-12-01 00:00:00