Cycle control with a 21-day compared with a 24-day oral contraceptive pill: a randomized controlled trial.

Abstract:

OBJECTIVE:To compare bleeding patterns between a 21/7-day triphasic norgestimate/ethinyl estradiol (E2) 25-microgram oral contraceptive pill (OCP) and a 24/4-day drospirenone/ethinyl E2 20-microgram OCP. METHODS:In a three-cycle, open-label, multicenter study, healthy, sexually active women were assigned randomly to a 21/7-day (norgestimate/ethinyl E2) or 24/4-day (drospirenone/ethinyl E2) OCP regimen. Randomization was stratified to assure a balanced distribution between regimens for "fresh starts" and "switchers." Bleeding data were collected daily using an interactive voice-response system. Bleeding was defined according to the 2007 U.S. Food and Drug Administration's Reproductive Health Drug Advisory Committee-endorsed criteria. RESULTS:Across the three cycles, the 21/7-day OCP group (n=165) reported fewer unscheduled bleeding days than did the 24/4-day OCP group (n=167) (mean 4.6 compared with 6.1 days, P=.003). Women using the 21/7-day OCP had significantly fewer episodes of unscheduled bleeding than did those using the 24/4-day OCP (mean 1.47 compared with 2.01, P=.001). Moreover, women using the 21/7-day OCP had a significantly lower absence of scheduled bleeding at each cycle (P<.001). Both regimens were well-tolerated. CONCLUSION:A 21-day norgestimate/ethinyl E2 25-microgram regimen results in less unscheduled bleeding and more scheduled bleeding than does a 24-day drospirenone/ethinyl E2 20-microgram regimen. CLINICAL TRIAL REGISTRATION:ClinicalTrials.gov, www.ClinicalTrials.gov, NCT00745901. LEVEL OF EVIDENCE:I.

journal_name

Obstet Gynecol

authors

Kaunitz AM,Burkman RT,Fisher AC,LaGuardia KD

doi

10.1097/AOG.0b013e3181beab47

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1205-1212

issue

6

eissn

0029-7844

issn

1873-233X

pii

00006250-200912000-00008

journal_volume

114

pub_type

杂志文章,多中心研究,随机对照试验
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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: McGregor JA,McFarren T

    更新日期:1989-03-01 00:00:00

  • Persistent ectopic syndrome: a case report and literature review.

    abstract::A case report is presented of an ampullary ectopic pregnancy which was treated by salpingostomy. Twenty-six days later, the patient underwent repeat operation due to the persistence of trophoblastic tissue within the fallopian tube. A review of the English literature reveals nine cases including our own that have been...

    journal_title:Obstetrics and gynecology

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    doi:

    authors: Bell OR,Awadalla SG,Mattox JH

    更新日期:1987-03-01 00:00:00

  • Ulipristal Acetate for Treatment of Uterine Leiomyomas: A Randomized Controlled Trial.

    abstract:OBJECTIVE:To assess the efficacy and tolerability of ulipristal acetate, a selective progesterone receptor modulator, for treatment of symptomatic uterine leiomyomas. METHODS:This phase 3, double-blind, double-dummy, placebo-controlled trial randomized premenopausal women (18-50 years) with uterine leiomyomas and abno...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/AOG.0000000000002942

    authors: Liu JH,Soper D,Lukes A,Gee P,Kimble T,Kroll R,Mallick M,Chan A,Gillard P,Harrington A,Sniukiene V,Shulman LP

    更新日期:2018-11-01 00:00:00

  • Use of vaginally administered chlorhexidine during labor to improve pregnancy outcomes.

    abstract:OBJECTIVE:Our objective was to determine the potential for chlorhexidine used as a vaginal and neonatal wash to reduce adverse outcomes of pregnancy, especially in developing countries. DATA SOURCES:We searched the English literature from January 1950 through October 2005 for all articles related to the use of chlorhe...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1097/01.AOG.0000215000.65665.dd

    authors: Goldenberg RL,McClure EM,Saleem S,Rouse D,Vermund S

    更新日期:2006-05-01 00:00:00

  • Adnexal masses in pregnancy: surgery compared with observation.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000157465.99639.e5

    authors: Schmeler KM,Mayo-Smith WW,Peipert JF,Weitzen S,Manuel MD,Gordinier ME

    更新日期:2005-05-01 00:00:00

  • Reliability of intrauterine pressure measurements.

    abstract::The reliability of intrauterine pressure measurements was studied by placing two catheters in the same uterus in women in labor. Nineteen parturients were studied, five with two Intran I catheters in different pockets of amniotic fluid, five with two Intran II catheters in different pockets, and nine with two Intran I...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Arulkumaran S,Yang M,Tien CY,Ratnam SS

    更新日期:1991-11-01 00:00:00

  • Academic manpower for obstetrics and gynecology in the United States.

    abstract::All 119 medical schools in the United States provided information for a study of academic manpower conducted by the Association of Professors of Gynecology and Obstetrics (APGO). The average number of full-time faculty members per medical school is 13.2, with 2 positions vacant per school. Subspecialists are concentra...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Messer RH,Pearse WH,Fielden JG

    更新日期:1979-05-01 00:00:00

  • Outpatient vaginal hysterectomy: optimizing perioperative management for same-day discharge.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/aog.0b013e3182732ece

    authors: Zakaria MA,Levy BS

    更新日期:2012-12-01 00:00:00

  • Fetal nucleated cells in maternal peripheral blood after delivery in cases of fetomaternal hemorrhage.

    abstract:OBJECTIVE:To determine how long fetal nucleated cells can be detected in maternal peripheral blood after delivery in cases of fetomaternal hemorrhage, using fluorescence in situ hybridization or polymerase chain reaction. METHODS:Nucleated cells with Y chromosomes were analyzed in 90 blood samples using fluorescence i...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0029-7844(94)00414-9

    authors: Hamada H,Arinami T,Hamaguchi H,Kubo T

    更新日期:1995-03-01 00:00:00

  • A false negative oxytocin challenge test.

    abstract::A negative oxytocin challenge test has been considered a very reassuring finding in managing pregnancies in which the fetus is at risk from uteroplacental insufficency. In the case described here a fetal death in utero occurred 4 days after a negative oxytocin challenge test in a Class D diabetic patient, but in that ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: McCranie WM,Niebyl JR

    更新日期:1977-02-01 00:00:00

  • Magnetic resonance imaging in human pregnancy.

    abstract::Magnetic resonance imaging is a new noninvasive diagnostic technique that involves no ionizing radiation, has no known significant adverse biologic effects, and produces high resolution cross-sectional body images. When compared with sonography and x-ray computed axial tomography, magnetic resonance imaging may have s...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Lowe TW,Weinreb J,Santos-Ramos R,Cunningham FG

    更新日期:1985-11-01 00:00:00

  • The management of preterm labor.

    abstract::Preterm birth is the leading cause of neonatal mortality and a substantial portion of all birth-related short- and long-term morbidity. Spontaneous preterm labor is responsible for more than half of preterm births. Its management is the topic of this review. Although there are many maternal characteristics associated ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/s0029-7844(02)02212-3

    authors: Goldenberg RL

    更新日期:2002-11-01 00:00:00

  • Flow cytometry of peritoneal washings in gynecologic neoplasia.

    abstract::A prospective, double blind study was initiated to compare flow cytometry to cytopathology in detecting malignant cells within peritoneal washings. Deoxyribonucleic acid (DNA) histograms were generated using 4',6-diamidino-2-phenylindole (DAPI) as a DNA fluorochrome. Evaluation of these data revealed a correlation of ...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/00006250-198605000-00014

    authors: Lovecchio JL,Budman DR,Susin M,Grueneberg D,Fenton AN

    更新日期:1986-05-01 00:00:00

  • Relationship between change in amniotic fluid index and volume of fluid removed at amnioreduction.

    abstract:OBJECTIVE:To determine the relationship between the change in amniotic fluid index (AFI) and the volume of fluid removed at amnioreduction. METHODS:In a prospective study of 20 twin and 19 singleton pregnancies undergoing amnioreduction for severe polyhydramnios, AFI was measured immediately before and after the proce...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(97)00356-6

    authors: Denbow ML,Sepulveda W,Ridout D,Fisk NM

    更新日期:1997-10-01 00:00:00

  • Mesenteric supernumerary ovary.

    abstract::Following is a report and a review of literature concerning the supernumerary ovary. Up to now only 7 cases have been reported, and our case appears to be the eighth. The anatomic situation in this case was unusual since it was found in the mesentery. Of the cases previously reported, 2 have been associated with benig...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Abrego D,Ibrahim AA

    更新日期:1975-03-01 00:00:00

  • Surveillance and management of patients at high genetic risk for ovarian carcinoma.

    abstract::The present study is concerned with surveillance/management programs for hereditary ovarian cancer syndromes. These syndromes lack distinguishing premonitory physical signs or biomarkers; therefore, in these genotypic settings, ovarian cancer risk must be assessed by analysis of the patient's pedigree. The authors des...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Lynch HT,Albano WA,Lynch JF,Lynch PM,Campbell A

    更新日期:1982-05-01 00:00:00

  • Pregnancy following surgical correction of nonfused müllerian bulbs and absent vagina.

    abstract::The authors treated a 15-year-old girl with a nonfused mullerian system and absence of the cervix and vagina. Surgical reconstruction of the uterus and vagina were performed, after which menstruation first appeared. Postoperative fibrotic stenosis obliterated almost the entire vagina except for a fine uterovaginal fis...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Singh J,Devi YL

    更新日期:1983-02-01 00:00:00

  • Physical Activity and Exercise During Pregnancy and the Postpartum Period: ACOG Committee Opinion, Number 804.

    abstract::Exercise, defined as physical activity consisting of planned, structured, and repetitive bodily movements done to improve one or more components of physical fitness, is an essential element of a healthy lifestyle, and obstetrician-gynecologists and other obstetric care providers should encourage their patients to cont...

    journal_title:Obstetrics and gynecology

    pub_type: 共识发展会议,杂志文章

    doi:10.1097/AOG.0000000000003772

    authors:

    更新日期:2020-04-01 00:00:00

  • Committee opinion no. 496: At-risk drinking and alcohol dependence: obstetric and gynecologic implications.

    abstract::Compared with men, at-risk alcohol use by women has a disproportionate effect on their health and lives, including reproductive function and pregnancy outcomes. Obstetrician–gynecologists have a key role in screening and providing brief intervention, patient education, and treatment referral for their patients who dri...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e31822c9906

    authors:

    更新日期:2011-08-01 00:00:00

  • Transobturator sling compared with single-incision mini-sling for the treatment of stress urinary incontinence: a randomized controlled trial.

    abstract:OBJECTIVE:To determine the efficacy and safety of a single-incision mini-sling compared with a transobturator midurethral sling for stress urinary incontinence (SUI) treatment. METHODS:This prospective single-center randomized controlled trial involved 130 women with a diagnosis of SUI. Primary outcomes were the objec...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/AOG.0000000000000148

    authors: Djehdian LM,Araujo MP,Takano CC,Del-Roy CA,Sartori MGF,Girão MJBC,Castro RA

    更新日期:2014-03-01 00:00:00

  • Minimally Invasive Surgery in Morbidly Obese Women.

    abstract::Minimally invasive gynecologic surgery provides a number of clinical advantages compared with open laparotomy. Over the past 25 years, important modifications and innovations have further expanded the utility of these techniques. Complications such as surgical site infection, venous thromboembolism, and wound cellulit...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000003588

    authors: Schorge JO

    更新日期:2020-01-01 00:00:00

  • Human immunodeficiency virus, pregnancy, and Stevens-Johnson syndrome.

    abstract:BACKGROUND:Stevens-Johnson syndrome and toxic epidermal necrolysis are life-threatening dermatologic disorders that are more common in the setting of a compromised immune system. We present the case of a pregnant patient with known human immunodeficiency virus (HIV) infection who presented with Stevens-Johnson syndrome...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000157766.49494.99

    authors: Shilad A,Predanic M,Perni SC,Houlihan C,Principe D

    更新日期:2005-05-01 00:00:00

  • Efficacy of different starting doses of oxytocin for induction of labor.

    abstract::One thousand twenty inductions of labor by amniotomy and continuous infusion of oxytocin at the Royal Women's Hospital were reviewed. Three different starting rates of infusion of oxytocin were used by altering the concentration to 2, 5, or 10 U/L. There was no difference in success of induction as measured by inducti...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Wein P

    更新日期:1989-12-01 00:00:00

  • Medical Education and Safety as Co-priorities in the Coronavirus Disease 2019 (COVID-19) Era: We Can Do Both.

    abstract::As hospitals and medical schools confronted coronavirus disease 2019 (COVID-19), medical students were essentially restricted from all clinical work in an effort to prioritize their safety and the safety of others. One downstream effect of this decision was that students were designated as nonessential, in contrast to...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000004113

    authors: Baecher-Lind L,Fleming AC,Bhargava R,Cox SM,Everett EN,Graziano SC,Katz NT,Sims SM,Morgan HK,Morosky CM,Sonn TS,Sutton JM,Royce CS,Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee

    更新日期:2020-10-01 00:00:00

  • A brief screening instrument to detect posttraumatic stress disorder in outpatient gynecology.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is a serious anxiety disorder triggered by the experience of trauma. One in 4 individuals exposed to trauma will develop PTSD. Victims of trauma are frequent users of health care, but screening is rarely done and most sequelae remain undetected. Our objectives were 1) to d...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/01.AOG.0000140683.43272.85

    authors: Meltzer-Brody S,Hartmann K,Miller WC,Scott J,Garrett J,Davidson J

    更新日期:2004-10-01 00:00:00

  • Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy.

    abstract::Collagen is a widespread body constituent that is affected by estrogen status in women. Its decrease after menopause can be prevented and/or restored by estrogen treatment. We explored the effect of four different hormonal replacement regimens on total skin collagen content by measuring hydroxyproline in skin biopsy s...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Brincat M,Versi E,Moniz CF,Magos A,de Trafford J,Studd JW

    更新日期:1987-07-01 00:00:00

  • Health Care Disparity and State-Specific Pregnancy-Related Mortality in the United States, 2005-2014.

    abstract:OBJECTIVE:To investigate factors associated with differential state maternal mortality ratios and to quantitate the contribution of various demographic factors to such variation. METHODS:In a population-level analysis study, we analyzed data from the Centers for Disease Control and Prevention National Center for Healt...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,收录出版

    doi:10.1097/AOG.0000000000001628

    authors: Moaddab A,Dildy GA,Brown HL,Bateni ZH,Belfort MA,Sangi-Haghpeykar H,Clark SL

    更新日期:2016-10-01 00:00:00

  • Fatal and Nonfatal Overdose Among Pregnant and Postpartum Women in Massachusetts.

    abstract:OBJECTIVE:To estimate fatal and nonfatal opioid overdose events in pregnant and postpartum women in Massachusetts, comparing rates in individuals receiving and not receiving pharmacotherapy for opioid use disorder (OUD). METHODS:We conducted a population-based retrospective cohort study using linked administrative and...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0000000000002734

    authors: Schiff DM,Nielsen T,Terplan M,Hood M,Bernson D,Diop H,Bharel M,Wilens TE,LaRochelle M,Walley AY,Land T

    更新日期:2018-08-01 00:00:00

  • The Q-tip test and urethrovesical junction mobility.

    abstract:OBJECTIVE:To determine the accuracy of the Q-tip test to measure urethrovesical junction mobility. METHODS:One hundred fourteen women with urinary incontinence or genital prolapse were evaluated with a Q-tip test and perineal ultrasound scanning to measure urethrovesical junction mobility with strain. The sensitivity,...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Caputo RM,Benson JT

    更新日期:1993-12-01 00:00:00

  • Conservative management of placenta percreta: experiences in two cases.

    abstract:BACKGROUND:The management of an abnormally invaded placenta presents a challenging obstetric problem. Recent reports have suggested that a conservative approach to the treatment of this condition is appropriate in selected cases. We present the courses of two women with suspected placenta percreta who were managed cons...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1097/AOG.0b013e3181794727

    authors: Hays AM,Worley KC,Roberts SR

    更新日期:2008-08-01 00:00:00