Abstract:
OBJECTIVE:This study assessed if lower than predicted serum leptin concentrations seen during weight loss persisted during weight regain, with possible implications for weight control. METHODS:115 children were investigated during a 12-week weight loss program. 90 children completed the program, and 68 children entered a follow-up program spanning 28 months. Measurements were performed at baseline and day 82 as well as at months 10, 16, and 28. Height, weight, body composition, Tanner stages, testicular size, and serum concentrations of leptin, and insulin were measured at all time points. RESULTS:Children with the greatest increases in BMI standard deviation score (SDS) exhibited the largest leptin increments. The disproportionate reduction of leptin seen during weight loss recovered after weight loss. Leptin increases mirrored increases in BMI SDS during weight regain, and the leptin-BMI SDS relationship seen during follow-up resembled the baseline leptin-BMI SDS relationship. CONCLUSION:Proportional increases of leptin and BMI SDS during weight regain suggests an intact leptin response during re-accumulation of fat. Following the pronounced reduction of leptin during weight loss, leptin levels were restored during weight regain to an extent where leptin levels were comparable with those at baseline, which is indicative of an inefficient lipostatic control exerted by leptin during weight regain.
journal_name
Obes Factsjournal_title
Obesity factsauthors
Holm JC,Gamborg M,Ward L,Ibsen KK,Gammeltoft S,Sørensen TI,Heitmann BLdoi
10.1159/000226619subject
Has Abstractpub_date
2009-01-01 00:00:00pages
243-8issue
4eissn
1662-4025issn
1662-4033pii
000226619journal_volume
2pub_type
杂志文章相关文献
Obesity Facts文献大全abstract:OBJECTIVES:Obesity in children and adolescents is a worldwide dramatic health problem, for which treatment is mostly unsuccessful. Therefore, prevention is the most important measure to tackle this problem. The 'EDDY' study as an interventional cohort study with a 1-year lifestyle intervention aimed to affect the lifes...
journal_title:Obesity facts
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000481140
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:Our aim was to review the effectiveness of physical activity promotion interventions in the worksite setting in Europe in order to identify those studies that had measured obesity-related outcomes and to evaluate how external validity of the findings had been assessed. METHODS:We conducted a review of studie...
journal_title:Obesity facts
pub_type: 杂志文章,评审
doi:10.1159/000335255
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to compare the effects of a low-intensity face-to-face therapy provided by a trained paediatrician to an intensive group therapy provided by a multidisciplinary team on the BMI of adolescents with obesity. METHODS:This longitudinal cohort study included 233 adolescents aged 11-18 years (mean...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000443694
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:As in many other countries around the world, the Netherlands has a high prevalence of overweight and obesity in children. About 1 in 7 of children aged 2-19 years has either overweight or obesity. SUMMARY:In this paper the national and local activities aimed at the prevention and management of obesity in ch...
journal_title:Obesity facts
pub_type: 杂志文章,评审
doi:10.1159/000509588
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Malposition or misplacement of gastric bands is a rare but recognised early complication of gastric band surgery. Malposition of the band would not normally result in significant weight loss after surgery. CASE REPORT:To our knowledge, we report the first case in the English literature of a malpositioned gas...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000342817
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The success of treatment for pediatric obesity is variable and often unsatisfactory. This study elucidates the influence of inattention and hyperactivity/impulsivity on short- and long-term weight loss and maintenance after outpatient treatment. METHODS:We included 8- to 16-year-old overweight and obese part...
journal_title:Obesity facts
pub_type: 临床试验,杂志文章
doi:10.1159/000346138
更新日期:2012-01-01 00:00:00
abstract::The current obesity epidemic poses a major public health issue since obesity predisposes towards several chronic diseases. BMI and total adiposity are positively correlated with cardiometabolic disease risk at the population level. However, body fat distribution and an impaired adipose tissue function, rather than tot...
journal_title:Obesity facts
pub_type: 杂志文章,评审
doi:10.1159/000471488
更新日期:2017-01-01 00:00:00
abstract:AIMS:To determine whether baseline levels of self-reported sleep and sleep problems among obese adolescents referred to an outpatient multidisciplinary family-based weight management program predict reduction in BMI 3 months later. METHODS:A retrospective medical chart review was conducted for 83 obese adolescents. Th...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000351819
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the association between overnutrition and scholastic achievement (SA). METHODS:A representative and proportional sample of 477 children of the 5th elementary school grade of both genders was randomly chosen during 2010, in the Metropolitan Region of Chile. SA was measured ...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000492004
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The stabilization in levels of childhood overweight has masked increasing gaps among different ethnic and socioeconomic groups in several countries. OBJECTIVE:To examine if levels and trends in childhood overweight and obesity differed by ethnicity and socioeconomic areas in Copenhagen schoolchildren. METH...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000446482
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to test the utility of preferred walk-run transition speed (WRTS) in exercise training adjunct to dietary restriction for obesity management in healthy obese women. MATERIALS AND METHODS:37 obese women (age: 35 ± 9 years, body mass index (BMI): 34.9 ± 4.6 kg/m(2)) were assigned to a...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000324579
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The objective of this study was to investigate differences in weight perception and self-concept of obese and lean children, and to examine parents' awareness of overweight in themselves and their children. A total of 59 obese patients aged 7-17 years and 49 of their parents from a pediatric obesity out-pati...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000295495
更新日期:2010-01-01 00:00:00
abstract:AIM:The aim of this study was to systematically describe the gender and ethnic differences regarding the prevalence of general/central obesity and cardiovascular disease (CVD) risk factors such as diabetes mellitus type 2, hypertension, and hypercholesterolemia among the indigenous and immigrant Pakistani communities. ...
journal_title:Obesity facts
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000357176
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Despite the abundance of data addressing the influence of patient's age on surgery-related complications, its impact on cardiometabolic outcomes following bariatric surgery has been overlooked. METHODS:Retrospective unicentric study of 1,728 obese patients who underwent bariatric surgery between January 2...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000511737
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVES:To examine the association between body mass index (BMI) and overuse injuries (OI) among Israel Defense Forces soldiers, in different corps. METHODS:Conscripts between 2003 and 2012, infantry, armored corps and intelligence corps (controls) were studied. OI data were taken from computerized patient records....
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000505836
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:The emergence of obesity as a distinct disease could have far reaching consequences for an organisation where optimum health and physical fitness are required for personnel to perform their occupational roles effectively. The objectives of this paper are to systematically review the literature concerning corr...
journal_title:Obesity facts
pub_type: 杂志文章,评审
doi:10.1159/000329450
更新日期:2011-01-01 00:00:00
abstract::The molecular genetic analysis of obesity has led to the identification of a limited number of confirmed major genes. While such major genes have a clear influence on the development of the phenotype, the underlying mutations are however (extremely) infrequent and thus of minor clinical importance only. The genetic pr...
journal_title:Obesity facts
pub_type: 杂志文章,评审
doi:10.1159/000113935
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Bariatric surgery has a considerable effect on weight loss. A positive relation of exercise and weight loss has been described before. However, the mode of exercise and its timing pre- or postoperatively or a combination remains unclear. METHODS:A multi-database search was conducted. Identified articles wer...
journal_title:Obesity facts
pub_type: 杂志文章,评审
doi:10.1159/000381201
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND/AIMS:Increasingly, an inflammatory modulating effect of adipokines within synovial joints is being recognized. To date, there has been no work examining a potential association between the presence of adipokines in the shoulder and patient-reported outcomes. This study undertakes an investigation assessing t...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000357230
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Melanocortin 3 and 4 receptors (MC3R and MC4R) are known to play an essential role in hypothalamic weight regulation. In addition to these two G-protein-coupled receptors (GPCRs), a huge number of other GPCRs are expressed in hypothalamic regions, and some of them are involved in weight regulation. So far, h...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000209862
更新日期:2009-01-01 00:00:00
abstract::The relationship between overeating, substance abuse and (behavioral) addiction is controversial. Medically established forms of addiction so far pertain to substance use disorders only. But the preliminary Diagnostic and Statistical Manual for Mental Disorders V (DSM V) suggests replacing the previous category 'Subst...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000338310
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Weight control through lifestyle interventions represents a suitable strategy to avoid the metabolic, endocrine, and reproductive comorbidities associated with overweight and obesity. Reduced testosterone (T) levels are a worsening factor in overweight males. However, prognostic parameters of long-term weigh...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000502119
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Currently, the two most common bariatric procedures are laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB). Long-term data comparing the two interventions in terms of their effect on body composition and bone mass density (BMD) are scarce. OBJECTIVE:The aim of this study...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000512450
更新日期:2020-12-17 00:00:00
abstract:BACKGROUND:Both group and individual modes of delivery are employed for obesity treatments. Commercial weight loss groups commonly employ group-based delivery, while many clinical based settings employ one-to-one delivery. We systematically reviewed randomised controlled trials of treatments for adult obesity to compar...
journal_title:Obesity facts
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000186144
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To estimate the excess costs of obese compared to normal-weight persons in Germany based on self-reported resource utilisation and work absence. METHODS:Five cross sectional surveys of cohort studies in southern Germany were pooled resulting in 9,070 observations for 6,731 individuals (31-96 years). BMI was ...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000452248
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The choice between different bariatric procedures for each patient is an important question in bariatric surgery. In this article, we explain criteria for patient selection for laparoscopic Roux-en-Y gastric bypass at the Obesity Center Wuerzburg and compare the corresponding outcomes for these selection cri...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000198261
更新日期:2009-01-01 00:00:00
abstract:AIMS:Patients' perceptions about weight-related stigma and discrimination were assessed in 2 groups of patients, obese and laparoscopic adjustable gastric banding (LAGB). METHODS:Seven focus group sessions were held including a total of 32 women, 8 obese (body mass index 35+) and 24 who had lost 50% of excess weight f...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000273206
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:The study aimed at investigating the lifetime prevalence of 22 self-harm behaviors in bariatric surgery candidates (pre-bariatric surgery group; PSG) compared to community controls with obesity (obese community group; OCG). METHODS:The Self-Harm Inventory (SHI) was administered to the PSG (n = 139, BMI ≥ 35 ...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000486484
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to define body fat percentiles for German children and adolescents aged 3-16 years using the largest German database. METHODS:The study population included 11,632 girls and 11,604 boys. Data were pooled from: i) Kiel Obesity Prevention Study (KOPS), acquisition period: 1996-2008, n ...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000336780
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Parents take an important role in a child's development, but there is currently limited information on parental correlates with children's health behaviour. The purpose of this study, therefore, was to examine whether parental characteristics, such as body weight, TV consumption and sport participation, affec...
journal_title:Obesity facts
pub_type: 杂志文章
doi:10.1159/000369984
更新日期:2014-01-01 00:00:00