Targeting IL-5 pathway against airway hyperresponsiveness: A comparison between benralizumab and mepolizumab.

abstract：:1. We have studied the transcellular biosynthesis of bioactive leukotrienes (LTs), generated upon blood cell-vascular wall interactions and their functional consequences, in the spontaneously beating, cell-perfused, heart of the rabbit. Rabbit isolated hearts were perfused under recirculating conditions (50 ml) with 5...

journal_title：British journal of pharmacology

authors： Sala A,Rossoni G,Buccellati C,Berti F,Folco G,Maclouf J

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Ischaemia compromises mitochondrial respiration. Consequently, the mitochondrial F1 Fo-ATPsynthase reverses and acts as a proton-pumping ATPase, so maintaining the mitochondrial membrane potential (ΔΨm ), while accelerating ATP depletion and cell death. Here we have looked for a molecule that can...

journal_title：British journal of pharmacology

authors： Ivanes F,Faccenda D,Gatliff J,Ahmed AA,Cocco S,Cheng CH,Allan E,Russell C,Duchen MR,Campanella M

更新日期：2014-09-01 00:00:00

abstract：:1. The effects of forskolin, prostaglandin E1 (PGE1), dibutyryl cyclic AMP (db cyclic AMP), dibutyryl cyclic GMP (db cyclic GMP) and 3-isobutyl-l-methyl-xanthine (IBMX) were investigated on the expression of tissue factor and thrombomodulin activities on the surface of human saphenous vein endothelial cells (HSVEC) in...

journal_title：British journal of pharmacology

authors： Archipoff G,Beretz A,Bartha K,Brisson C,de la Salle C,Froget-Léon C,Klein-Soyer C,Cazenave JP

更新日期：1993-05-01 00:00:00

abstract：:1. The drug HA-966 (1-hydroxy-3-amino-pyrrolidone-2), which chemically resembles the cyclic form of GABA, has been studied for neuro-pharmacological properties and for effects on the catecholamine content of the corpus striatum.2. The acute effects on spontaneous behaviour of rodents included flaccid catalepsy and rev...

journal_title：British journal of pharmacology

authors： Bonta IL,De Vos CJ,Grijsen H,Hillen FC,Noach EL,Sim AW

更新日期：1971-11-01 00:00:00

abstract：:Knowledge of the cardiac safety of emerging new drugs is an important aspect of assuring the expeditious advancement of the best candidates targeted at unmet medical needs while also assuring the safety of clinical trial subjects or patients. Present methodologies for assessing drug-induced torsades de pointes (TdP) a...

journal_title：British journal of pharmacology

authors： Bass AS,Darpo B,Breidenbach A,Bruse K,Feldman HS,Garnes D,Hammond T,Haverkamp W,January C,Koerner J,Lawrence C,Leishman D,Roden D,Valentin JP,Vos MA,Zhou YY,Karluss T,Sager P

更新日期：2008-08-01 00:00:00

abstract：:1. Capsaicin, the irritant principle of hot peppers, is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (VR1), recently reported to be involved in neurodegeneration. The present study investigated the role of VR1 in a model of global cerebral ischemia in gerb...

journal_title：British journal of pharmacology

authors： Pegorini S,Braida D,Verzoni C,Guerini-Rocco C,Consalez GG,Croci L,Sala M

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Positive modulators of small conductance Ca(2+)-activated K(+) channels (SK1, SK2, and SK3) exert hyperpolarizing effects that influence the activity of excitable and non-excitable cells. The prototype compound 1-EBIO or the more potent compound NS309, do not distinguish between the SK subtypes a...

journal_title：British journal of pharmacology

authors： Hougaard C,Eriksen BL,Jørgensen S,Johansen TH,Dyhring T,Madsen LS,Strøbaek D,Christophersen P

更新日期：2007-07-01 00:00:00

abstract：:1. Caerulein displayed a potent stimulant action on pancreatic secretion in the dog. Threshold doses were 1-5 ng/kg by rapid intravenous injection, 0.25-1 ng/kg per min by intravenous infusion and 50-100 ng/kg by subcutaneous injection. There was a conspicuous increase not only in the volume flow of pancreatic juice b...

journal_title：British journal of pharmacology

authors： Bertaccini G,De Caro G,Endean R,Erspamer V,Impicciatore M

更新日期：1969-09-01 00:00:00

abstract：:Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological interventions for their management. More targeted and less invasive therapies...

journal_title：British journal of pharmacology

authors： Rietdorf K,MacQueen H

更新日期：2017-10-01 00:00:00

abstract：:1. Pre-eclampsia is a serious pregnancy disorder associated with widespread activation of the maternal vascular endothelium. Recent evidence implicates a role for oxidative stress in the aetiology of this condition. 2. Reactive oxygen species, particularly superoxide anions, invokes endothelial cell activation through...

journal_title：British journal of pharmacology

authors： Crocker IP,Kenny LC,Thornton WA,Szabo C,Baker PN

更新日期：2005-03-01 00:00:00

abstract：:1 Salbutamol and disodium cromoglycate were compared for anti-anaphylactic activity against passive anaphylaxis in rat skin and peritoneum in vivo and in rat mast cells and human lung fragments in vitro.2 Salbutamol administered intravenously to rats inhibited cutaneous anaphylaxis, but also inhibited cutaneous respon...

journal_title：British journal of pharmacology

authors： Butchers PR,Fullarton JR,Skidmore IF,Thompson LE,Vardey CJ,Wheeldon A

更新日期：1979-09-01 00:00:00

abstract：:1. The mechanisms underlying the vasodilator response to urocortin are incompletely understood. The present study was designed to examine the role of endothelial nitric oxide and Ba(2+)-sensitive K(+) channels in the endothelium-dependent component of urocortin-induced relaxation in the rat left anterior descending co...

journal_title：British journal of pharmacology

authors： Huang Y,Chan FL,Lau CW,Tsang SY,He GW,Chen ZY,Yao X

更新日期：2002-03-01 00:00:00

abstract：:We have examined the effects of antagonists on the isometric contraction of the human saphenous vein produced by 5-hydroxytryptamine (5-HT). The 5-HT2-antagonist ketanserin (1 microM) had little effect on the lower part of the concentration-response curve to 5-HT, but markedly shifted the upper part of the curve. Yohi...

journal_title：British journal of pharmacology

authors： Docherty JR,Hyland L

更新日期：1986-09-01 00:00:00

abstract：:1. To investigate the quantitative relationship between elevation in the intracellular Ca(2+) concentration ([Ca(2+)](i)) and nitric oxide (NO) production, the changes in [Ca(2+)](i) and NO production were determined in parallel, using fluorimetry of fura-2 and 2, 3-diaminonaphthalene, respectively, in endothelial cel...

journal_title：British journal of pharmacology

authors： Mizuno O,Kobayashi S,Hirano K,Nishimura J,Kubo C,Kanaide H

更新日期：2000-07-01 00:00:00

abstract：:1 Morphine-theophylline interactions were investigated in both acute and narcotic-dependent preparations, in vitro and in vivo, using four different experimental models: LD50 doses of morphine and naloxone in the mouse; naloxone-induced contractions in the electrically-stimulated and opiate-dependent isolated ileum of...

journal_title：British journal of pharmacology

authors： Brailowsky S,Guerrero-Muñoz F,Luján M,Shkurovich M

更新日期：1981-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age related neurodegenerative disease. Currently, there are no disease modifying drugs, existing therapies only offer short-term symptomatic relief. Two of the pathognomonic indicators of AD are the presence of extracellular protein aggregates consisting primarily of the Aβ ...

journal_title：British journal of pharmacology

authors： Kenche VB,Barnham KJ

更新日期：2011-05-01 00:00:00

abstract：:1 The question whether constriction of local vessels is essential for the anti-inflammatory action of glucocorticoids in carrageenin-induced granulomatous inflammation was studied. 2 The vasodilator prostaglandin E1 injection into the granuloma pouch fluid increased the exudation of plasma protein into the granuloma t...

journal_title：British journal of pharmacology

authors： Sugio K,Tsurufuji S

更新日期：1981-07-01 00:00:00

abstract：:1 Anthopleurin-B (AP-B, greater than 3 x 10(-9) M), a newly isolated polypeptide from sea anemone (Anthopleura xanthogrammica), caused powerful rhythmic contractions in the guinea-pig isolated vas deferens. The other polypeptides anthopleurin-A from A. xanthogrammica and anthopleurin-C from A. elegantissima, elicited ...

journal_title：British journal of pharmacology

authors： Norton TR,Ohizumi Y,Shibata S

更新日期：1981-09-01 00:00:00

abstract：:The metabolism and efficacy of 5-fluorouracil (FUra) and other fluorinated pyrimidine (FP) derivatives have been intensively investigated for over fifty years. FUra and its antimetabolites can be incorporated at RNA- and DNA-levels, with RNA level incorporation provoking toxic responses in human normal tissue, and DNA...

journal_title：British journal of pharmacology

authors： Li LS,Morales JC,Veigl M,Sedwick D,Greer S,Meyers M,Wagner M,Fishel R,Boothman DA

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Anandamide (AEA) activates both cannabinoid CB(1) and TRPV1 receptors, which are expressed on cultured dorsal root ganglion neurones. Increased levels of nerve growth factor (NGF) are associated with chronic pain states. EXPERIMENTAL APPROACH:The aim of this study was to compare of the effects of AEA on CB(...

journal_title：British journal of pharmacology

authors： Evans RM,Scott RH,Ross RA

更新日期：2007-10-01 00:00:00

abstract：:1. The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water...

journal_title：British journal of pharmacology

authors： Vickers SP,Benwell KR,Porter RH,Bickerdike MJ,Kennett GA,Dourish CT

更新日期：2000-07-01 00:00:00

abstract：:Rabbits treated with 2-deoxy-D-glucose (2DG) (300 mg/kg) show an increased intake of food and water. Pretreatment with haloperidol (1 mg/kg) abolishes the increase in water intake but does not prevent the increase in food intake. ...

journal_title：British journal of pharmacology

authors： Anderson J,Sharman DF,Stephens DB

更新日期：1979-05-01 00:00:00

abstract：:1. The dihydropyridine calcium channel activator, Bay K 8644, is believed to increase mean arterial blood pressure in several animal models, as a result of direct activation of vascular smooth muscle cells by increasing calcium influx through the voltage-dependent calcium channels. The purpose of the current study was...

journal_title：British journal of pharmacology

authors： Moreland S,Ushay MP,Kimball SD,Powell JR,Moreland RS

更新日期：1988-04-01 00:00:00

abstract：:Effects of isoprenaline (Isop) on the contractile properties of the smooth muscle cells of cat trachea were investigated using intact and chemically skinned muscle preparations and an isometric tension recording method. In the intact muscle preparations, Isop 3 X 10(-10) or 3 X 10(-9) M significantly suppressed the am...

journal_title：British journal of pharmacology

authors： Ito Y,Itoh T

更新日期：1984-11-01 00:00:00

abstract：:Cholesterol and oxysterol sulfates are important regulators of lipid metabolism, inflammation, cell apoptosis, and cell survival. Among the sulfate-based lipids, cholesterol sulfate (CS) is the most studied lipid both quantitatively and functionally. Despite the importance, very few studies have analysed and linked th...

journal_title：British journal of pharmacology

authors： Sanchez LD,Pontini L,Marinozzi M,Sanchez-Aranguren LC,Reis A,Dias IHK

更新日期：2020-08-06 00:00:00

abstract：BACKGROUND AND PURPOSE:Marijuana smoking is widespread in many countries, and the use of smoked synthetic cannabinoids is increasing. Smoking a marijuana joint leads to bronchodilation in both healthy subjects and asthmatics. The effects of Δ(9) -tetrahydrocannabinol and synthetic cannabinoids on human bronchus reactiv...

journal_title：British journal of pharmacology

authors： Grassin-Delyle S,Naline E,Buenestado A,Faisy C,Alvarez JC,Salvator H,Abrial C,Advenier C,Zemoura L,Devillier P

更新日期：2014-06-01 00:00:00

abstract：:Endothelin constricted human isolated cerebral arteries in a concentration-dependent manner. The maximal tension developed, as well as EC50 values were similar in arteries with and without endothelium. Removal of extracellular calcium or addition of the calcium antagonist nicardipine (10(-6)M), attenuated but did not ...

journal_title：British journal of pharmacology

authors： de Aguilera EM,Irurzun A,Vila JM,Aldasoro M,Galeote MS,Lluch S

更新日期：1990-03-01 00:00:00

abstract：:1. A technique for the close-arterial administration of substances to the rat stomach in vivo has been developed. 2. Intra-arterial infusion of platelet-activating factor (Paf, 10-50 ng kg-1 min-1 for 10 min) induced macroscopically assessed damage in the corpus mucosa, characterized as vasocongestion and necrosis. 3....

journal_title：British journal of pharmacology

authors： Esplugues JV,Whittle BJ

更新日期：1988-01-01 00:00:00

abstract：:In the last 20 years, the global regulatory frameworks for drug assessment have been managing the challenges posed by using cellular products as new therapeutic tools. Currently, they are defined as "Advanced Therapy Medicinal Products", comprising a large group of cellular types that either alone or in combination wi...

journal_title：British journal of pharmacology

authors： Ciccocioppo R,Comoli P,Astori G,Del Bufalo F,Prapa M,Dominici M,Locatelli F

更新日期：2020-11-03 00:00:00

abstract：:1. The effects of various inhibitors of the mitochondrial electron transport chain on the activity of ATP-sensitive K+ channels were examined in the Cambridge rat insulinoma G1 (CRI-G1) cell line using a combination of whole cell and single channel recording techniques. 2. Whole cell current clamp recordings, with 5 m...

journal_title：British journal of pharmacology

authors： Harvey J,Hardy SC,Ashford ML

更新日期：1999-01-01 00:00:00