Morphine-theophylline interaction: antagonism or facilitation?

Abstract:

:1 Morphine-theophylline interactions were investigated in both acute and narcotic-dependent preparations, in vitro and in vivo, using four different experimental models: LD50 doses of morphine and naloxone in the mouse; naloxone-induced contractions in the electrically-stimulated and opiate-dependent isolated ileum of the guinea-pig; naloxone-induced jumps in the mouse; an calcium uptake in synaptosomal preparations. 2 The LD50 of morphine was significantly increased by theophylline. 3 The lethal effect of theophylline was potentiated by pretreatment of the animals with naloxone. 4 Theophylline displayed protective effects in the inhibitory response to morphine and antagonism to the withdrawal response induced by naloxone in the electrically-stimulated isolated ileum of the guinea-pig. 5 The number of jumps induced by naloxone in morphine-dependent mice was significantly diminished by theophylline. 6 The inhibitory effect of morphine on the synaptosomal uptake of calcium was decreased by theophylline. 7 The effects of both morphine and theophylline on the cyclic nucleotides and the possible role of calcium in these actions are discussed.

journal_name

Br J Pharmacol

authors

Brailowsky S,Guerrero-Muñoz F,Luján M,Shkurovich M

doi

10.1111/j.1476-5381.1981.tb08742.x

subject

Has Abstract

pub_date

1981-08-01 00:00:00

pages

887-92

issue

4

eissn

0007-1188

issn

1476-5381

journal_volume

73

pub_type

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