Abstract:
BACKGROUND/AIM:In adults, studies have shown that obesity is a chronic low-grade inflammatory state characterized by altered levels of cytokines. Studies in children have mainly focused on C-reactive protein and adiponectin, and there is limited data for other inflammatory markers in healthy weight and overweight children. The aim of this study was to measure IL-6, IL-8 and IL-10 levels in healthy normal weight and overweight children at 8 and 15 years. METHODS:118 normal weight and overweight children (59 boys) from the Nepean longitudinal study were recruited at age 8 years and followed up at 15 years. Serum IL-6, IL-8 and IL-10 levels were measured at both time-points. RESULTS:At 8 years, we found no significant differences in cytokine levels between normal weight and overweight (owt)/obese (ob) groups. However, at 15 years, owt/ob girls (n = 23) had higher levels of IL-6 (p = 0.04), IL-8 (p = 0.04) and IL-10 (p = 0.03) compared to normal weight girls (n = 36), even after adjustment for puberty; no differences were seen in boys. CONCLUSION:The effects of obesity on IL-6, IL-8 and IL-10 levels vary with age and sex, with owt/ob girls at 15 years showing raised IL-6, IL-8 and IL-10 levels compared to healthy weight girls.
journal_name
Horm Res Paediatrjournal_title
Hormone research in paediatricsauthors
Tam CS,Garnett SP,Cowell CT,Heilbronn LK,Lee JW,Wong M,Baur LAdoi
10.1159/000277632subject
Has Abstractpub_date
2010-01-01 00:00:00pages
128-34issue
2eissn
1663-2818issn
1663-2826pii
000277632journal_volume
73pub_type
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journal_title:Hormone research in paediatrics
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