Abstract:
AIMS:Hyperinsulinemic hypoglycemia (HH) is common in small-for-gestational-age (SGA) neonates. Diazoxide is often used as the first-line medication for HH in SGA neonates. Unfortunately, diazoxide is not authorized in China. We examined the effectiveness of octreotide as an alternative therapy to treat HH in SGA neonates. There is limited data on the use of octreotide in HH of SGA neonates. METHODS:Seven SGA neonates with HH who were admitted to the Department of Neonatology at the Third Affiliated Hospital of Sun Yat-sen University between January 2013 and December 2014 received octreotide at an initial dose of 5 μg/kg/day through subcutaneous injection at 8-hour intervals. Depending on the glycemic control, the dose of octreotide was increased in increments of 2-5 μg/kg/day every 3-5 days to the maximum dose of 30 μg/kg/day. RESULTS:The age of neonates with HH diagnosis ranged from 1 to 4 days. The maximum dose of octreotide ranged from 8 to 18 μg/kg/day. The duration of octreotide therapy ranged from 9 to 45 days. All patients had a clear glycemic response to octreotide, and no major adverse events were observed during the treatment. CONCLUSIONS:Octreotide may be a useful alternative therapy in HH of SGA neonates when diazoxide is unavailable.
journal_name
Horm Res Paediatrjournal_title
Hormone research in paediatricsauthors
Pan S,Zhang M,Li Ydoi
10.1159/000441108subject
Has Abstractpub_date
2015-01-01 00:00:00pages
383-7issue
6eissn
1663-2818issn
1663-2826pii
000441108journal_volume
84pub_type
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journal_title:Hormone research in paediatrics
pub_type: 杂志文章,随机对照试验
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journal_title:Hormone research in paediatrics
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Hormone research in paediatrics
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journal_title:Hormone research in paediatrics
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Hormone research in paediatrics
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Hormone research in paediatrics
pub_type: 临床试验,杂志文章
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journal_title:Hormone research in paediatrics
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00