Thyroid Sequelae of Pediatric Cancer Therapy.

Abstract:

:The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Thyroid sequelae resulting from irradiation may manifest only after years to decades of follow-up, and their resultant clinical symptoms may be indolent and non-specific. Therefore, lifelong monitoring of the childhood cancer survivor at risk for thyroid disease is paramount. In this comprehensive review, the myriad thyroid adverse effects resulting from pediatric cancer treatment are discussed and an overview of screening and treatment of these thyroid sequelae provided.

journal_name

Horm Res Paediatr

authors

Waguespack SG

doi

10.1159/000495040

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

104-117

issue

2

eissn

1663-2818

issn

1663-2826

pii

000495040

journal_volume

91

pub_type

杂志文章,评审
  • Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency.

    abstract:BACKGROUND:Hyperandrogenism is a rare symptom of juvenile ovarian granulosa cell- tumors (JGCTO). This study aimed to determine whether hyperandrogenism was related to overexpression of SOX9, decreased expression of FOXL2 or absent aromatase expression in tumor with particular scheme of expression of P450scc and P450c1...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000313396

    authors: Kalfa N,Méduri G,Philibert P,Patte C,Boizet-Bonhoure B,Thibaut E,Pienkowski C,Jaubert F,Misrahi M,Sultan C

    更新日期:2010-01-01 00:00:00

  • Congenital Hypothyroidism: 8-Year Experience Using 2 Newborn Screens in Alabama.

    abstract:BACKGROUND/AIMS:Newborn screening protocols for congenital hypothyroidism (CH) vary as to whether a TSH or T4 algorithm or some combination is performed. We aimed to determine the 3-year clinical outcome of infants diagnosed with CH and screen-positive for CH using a 2-screen protocol that measures both T4 and TSH on a...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000501395

    authors: Pitts L,McCormick W,Mick GJ

    更新日期:2019-01-01 00:00:00

  • Monogenic Disorders of Adrenal Steroidogenesis.

    abstract::Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches of the steroidogenic machinery involved in the production of mineralocorticoids, glucocorticoids, and androgens. This mini review describes t...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000488034

    authors: Baranowski ES,Arlt W,Idkowiak J

    更新日期:2018-01-01 00:00:00

  • Predictors of Loss to Follow-Up among Children with Type 2 Diabetes.

    abstract:BACKGROUND/AIMS:Youth with type 2 diabetes (T2D) have poor compliance with medical care. This study aimed to determine which demographic and clinical factors differ between youth with T2D who receive care in a pediatric diabetes center versus youth lost to follow-up for >18 months. METHODS:Data were analyzed from 496 ...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000475595

    authors: Shoemaker A,Cheng P,Gal RL,Kollman C,Tamborlane WV,Klingensmith GJ,Clements MA,Hannon TS,Heptulla R,Less J,Wood J,for the Pediatric Diabetes Consortium.

    更新日期:2017-01-01 00:00:00

  • Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism.

    abstract::Feeding problems are frequent in infants with congenital hyperinsulinism (HI) and may be exacerbated by continuous enteral nutrition (EN) used to maintain euglycemia. Our center's HI team uses dextrose solution given continuously via gastric tube (intrasgastric dextrose, IGD) for infants not fully responsive to conven...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验

    doi:10.1159/000491105

    authors: Vajravelu ME,Congdon M,Mitteer L,Koh J,Givler S,Shults J,De León DD

    更新日期:2019-01-01 00:00:00

  • Pituitary Antibodies in an Adolescent with Secondary Adrenal Insufficiency and Turner Syndrome.

    abstract:BACKGROUND/AIMS:Autoimmune hypophysitis (AH) is a rare inflammatory disease of the pituitary gland causing varying degrees of hypopituitarism and/or sellar compression. Cranial MRI remains the best noninvasive tool to diagnose AH, although a diagnosis of certainty requires pituitary biopsy. The objective of this study ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000446912

    authors: Pollock AJ,Seibert TS,Salvatori C,Caturegli P,Allen DB

    更新日期:2017-01-01 00:00:00

  • Woodhouse-Sakati syndrome in an Israeli-Arab family presenting with youth-onset diabetes mellitus and delayed puberty.

    abstract:BACKGROUND AND OBJECTIVE:Woodhouse-Sakati syndrome (WSS) is a rare autosomal-recessive disorder characterized by a combination of hypogonadism, alopecia, diabetes mellitus (DM), mental retardation and extrapyramidal signs, not described previously in Israel. Our aim was to study the clinical and genetic characteristics...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000323441

    authors: Rachmiel M,Bistritzer T,Hershkoviz E,Khahil A,Epstein O,Parvari R

    更新日期:2011-01-01 00:00:00

  • Deficits in Bone Geometry in Growth Hormone-Deficient Prepubertal Boys Revealed by High-Resolution Peripheral Quantitative Computed Tomography.

    abstract:INTRODUCTION:Although growth hormone (GH) is essential for attainment of peak bone mass, bone health in prepubertal children with GH deficiency is not routinely evaluated. The objective of this study was to evaluate bone microarchitecture in GH-deficient (GHD) boys using high-resolution peripheral quantitative computed...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000506229

    authors: Baer TG,Agarwal S,Chen S,Chiuzan C,Sopher AB,Tao R,Hassoun A,Shane E,Fennoy I,Oberfield SE,Vuguin PM

    更新日期:2019-01-01 00:00:00

  • A new horizon for glucose monitoring.

    abstract::Regular self-monitoring of blood glucose is crucial for proper insulin dosing and gives a reliable foundation for reasonable glycaemic control. According to recent data, recommended values for glycated haemoglobin A1c as set by the professional associations remain out of the reach for a large proportion of the paediat...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000368924

    authors: Dovč K,Bratina N,Battelino T

    更新日期:2015-01-01 00:00:00

  • Impact of Endocrine Disruptors on the Thyroid Hormone System.

    abstract::The thyroid hormone (TH) system plays a central role in central physiological processes of many species, including mammals and humans, ranging from growth and cell differentiation, energy metabolism, thermoregulation and phasing of hibernation or annual movements of migratory species, metamorphosis from larvae to adul...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000443501

    authors: Gutleb AC,Cambier S,Serchi T

    更新日期:2016-01-01 00:00:00

  • Adrenocortical hormonal activity in 20-year-old subjects born small or appropriate for gestational age.

    abstract:BACKGROUND:Altered adrenocortical activity is one suggested mechanism relating small birth size with the metabolic syndrome in adulthood. Adrenal androgen concentrations are higher in children born small (SGA) than appropriate for gestational age (AGA). AIM:To compare adrenocortical hormonal activity between 20-year-o...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000338344

    authors: Todorova B,Salonen M,Jääskeläinen J,Tapio A,Jääskeläinen T,Palvimo J,Turpeinen U,Hämäläinen E,Räsänen M,Tenhola S,Voutilainen R

    更新日期:2012-01-01 00:00:00

  • IGF2 methylation is associated with lipid profile in obese children.

    abstract:AIM:Our aim was to investigate the relationships between the degree of IGF2 methylation and the metabolic status in obese children and adolescents. SUBJECTS AND METHODS:Eighty-five obese subjects aged 11.6 ± 2.1 years were studied. Anthropometry, metabolic parameters, blood pressure and body composition were assessed....

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000351707

    authors: Deodati A,Inzaghi E,Liguori A,Puglianiello A,Germani D,Brufani C,Fintini D,Cappa M,Barbetti F,Cianfarani S

    更新日期:2013-01-01 00:00:00

  • Triple A Syndrome: Preliminary Response to the Antioxidant N-Acetylcysteine Treatment in a Child.

    abstract:INTRODUCTION:Triple A syndrome (AAAS) is a rare autosomal recessive disorder characterized by alacrima, achalasia, ACTH-resistant adrenal insufficiency, autonomic dysfunction, and progressive neurodegeneration. Increased oxidative stress, demonstrated in patients' fibroblasts in vitro, may be a central disease mechanis...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000465520

    authors: Fragoso MCBV,Albuquerque EVA,Cardoso ALA,da Rosa PWL,de Paulo RB,Schimizu MHM,Seguro AC,Passarelli M,Koehler K,Huebner A,Almeida MQ,Latronico AC,Arnhold IJP,Mendonca BB

    更新日期:2017-01-01 00:00:00

  • Correlation between Cosyntropin Stimulation Study and Disease Severity in Children with Fluid- and Catecholamine-Refractory Shock in the Pediatric and Cardiovascular Intensive Care Unit.

    abstract:BACKGROUND:The cosyntropin stimulation study (CSS) measures the patient's ability to adequately mount a cortisol response. Clinically, CSS results may not be used to guide hydrocortisone use. The objective of this study was to examine how the CSS results are associated with clinical parameters, mortality/disease severi...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000484561

    authors: Iyer P,Harrington B,Fadrowski JJ,Sibinga E,Amankwah EK

    更新日期:2018-01-01 00:00:00

  • Exploring clinician confidence in the management of adolescent menstrual and reproductive health problems.

    abstract:PURPOSE:A high incidence of menstrual problems is reported in adolescent girls, with significant attendant morbidity. The majority are likely to be seen and managed by doctors other than specialist gynaecologists. This study aimed to survey the practice of doctors other than gynaecologists, to establish their chosen th...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000356920

    authors: Neylon OM,Grover SR,Zacharin M

    更新日期:2014-01-01 00:00:00

  • Why is the thyroid so prone to autoimmune disease?

    abstract::The thyroid gland plays a major role in the human body; it produces the hormones necessary for appropriate energy levels and an active life. These hormones have a critical impact on early brain development and somatic growth. At the same time, the thyroid is highly vulnerable to autoimmune thyroid diseases (AITDs). Th...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000324442

    authors: Saranac L,Zivanovic S,Bjelakovic B,Stamenkovic H,Novak M,Kamenov B

    更新日期:2011-01-01 00:00:00

  • An Intron 9 CYP19 Gene Variant (IVS9+5G>A), Present in an Aromatase-Deficient Girl, Affects Normal Splicing and Is Also Present in Normal Human Steroidogenic Tissues.

    abstract:BACKGROUND/AIMS:Splicing CYP19 gene variants causing aromatase deficiency in 46,XX disorder of sexual development (DSD) patients have been reported in a few cases. A misbalance between normal and aberrant splicing variants was proposed to explain spontaneous pubertal breast development but an incomplete sex maturation ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000437142

    authors: Saraco N,Nesi-Franca S,Sainz R,Marino R,Marques-Pereira R,La Pastina J,Perez Garrido N,Sandrini R,Rivarola MA,de Lacerda L,Belgorosky A

    更新日期:2015-01-01 00:00:00

  • Health problems in congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract::Following the introduction of life-saving glucocorticoid replacement 60 years ago, congenital adrenal hyperplasia (CAH) has evolved from being perceived as a paediatric disorder to being recognized as a lifelong, chronic condition affecting patients of all age groups. Increasing evidence suggests that patients with CA...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000327794

    authors: Reisch N,Arlt W,Krone N

    更新日期:2011-01-01 00:00:00

  • Study of primary IGF-1 deficiency in Egyptian children with idiopathic short stature.

    abstract:BACKGROUND/AIMS:Primary insulin-like growth factor-1 (IGF-1) deficiency (IGFD) is defined by low levels of IGF-1 without growth hormone (GH) deficiency and absence of secondary causes. The aim of this study was to evaluate IGF-1 in Egyptian children with idiopathic short stature (ISS) and describe patients with IGFD. ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000350824

    authors: Anwar GM,Kandeel WA,Mandour IA,Kamal AN

    更新日期:2013-01-01 00:00:00

  • Long-term follow-up and mutation analysis of 27 chinese cases of congenital hyperinsulinism.

    abstract:OBJECTIVES:Long-term clinical follow-up and mutation analysis were performed in 27 Chinese congenital hyperinsulinism patients. METHOD:27 hypoglycemia patients were diagnosed with CHI within 2 years of age. The long-term clinical outcome was analyzed and mutation analysis of 5 hyperinsulinism candidate genes was perfo...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000356911

    authors: Su C,Gong C,Sanger P,Li W,Wu D,Gu Y,Cao B

    更新日期:2014-01-01 00:00:00

  • Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study.

    abstract:BACKGROUND/AIMS:The autonomic nervous system (ANS) provides neurogenic control of inflammatory reactions. ANS changes in obesity may result in inflammation. This study sought to gain insight into cardiac autonomic dysfunction and inflammation in childhood obesity, and to gather pilot data on the potential relationship ...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000445685

    authors: Hursh BE,Fazeli MS,Wang S,Marchant EA,Woo P,Elango R,Lavoie PM,Chanoine JP,Collet JP

    更新日期:2016-01-01 00:00:00

  • Continuous Glucose Monitoring Systems: Are They Useful for Evaluating Glycemic Control in Children with Hyperinsulinism?

    abstract:BACKGROUND:Effective treatment and close monitoring in children with congenital hyperinsulinism (HI) are important to prevent hypoglycemic-associated brain damage. The current monitoring approach involves measuring plasma glucose intermittently, but this does not provide a comprehensive assessment of glycemic control a...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000506230

    authors: Rayannavar A,Elci OU,Mitteer L,De León DD

    更新日期:2019-01-01 00:00:00

  • Hypercalcaemia in a Patient with 2p13.2-p16.1 Duplication.

    abstract:BACKGROUND:Partial duplication of 2p is a rare condition that causes facial anomalies, psychomotor delay, and growth failure. Hypercalcaemia is rare in children. So far, duplication of 2p has never been associated with hypercalcaemia. METHODS:Here, we report a girl with a partial duplication of 2p presenting with mode...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000442747

    authors: Lodefalk M,Frykholm C,Esbjörner E,Ljunggren Ö

    更新日期:2016-01-01 00:00:00

  • Prenatal Treatment of Congenital Adrenal Hyperplasia: Long-Term Effects of Excess Glucocorticoid Exposure.

    abstract::Prenatal treatment of congenital adrenal hyperplasia with dexamethasone (DEX) has been in use since the mid-1980s and has proven effective at reducing virilization of external genitalia in affected girls. However, multiple experimental studies on animals and clinical studies on humans show that prenatal administration...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000485100

    authors: Lajic S,Karlsson L,Nordenström A

    更新日期:2018-01-01 00:00:00

  • Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty.

    abstract:BACKGROUND:The flare-up effect of GnRH analogues may cause transient uterine bleeding in girls affected with idiopathic central precocious puberty (ICPP). AIMS:To assess the incidence of endometrial bleeding and verify whether pretreatment with cyproterone acetate could counteract it. METHODS:Fifty-four girls affecte...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000308172

    authors: Seminara S,Nanni L,Generoso M,Mirri S,Leonardi V,Slabadzianiuk T,Vetrano ML,Buongiorno A,Losi S,Galluzzi F

    更新日期:2010-01-01 00:00:00

  • Central precocious puberty due to hypothalamic hamartomas correlates with anatomic features but not with expression of GnRH, TGFalpha, or KISS1.

    abstract:BACKGROUND/AIMS:Hypothalamic hamartomas are the most common identifiable cause of central precocious puberty (CPP). Hamartoma characteristics proposed to be associated with CPP include specific anatomic features and expression of molecules such as gonadotropin-releasing hormone (GnRH), transforming growth factor alpha ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000308162

    authors: Chan YM,Fenoglio-Simeone KA,Paraschos S,Muhammad L,Troester MM,Ng YT,Johnsonbaugh RE,Coons SW,Prenger EC,Kerrigan JF Jr,Seminara SB

    更新日期:2010-01-01 00:00:00

  • Similar Cause, Different Phenotype: SOX9 Enhancer Duplication in a Family.

    abstract:INTRODUCTION:46,XX ovotesticular disorder of sex development (DSD), as defined by the Chicago consensus in 2006, is characterized by histologically confirmed testicular and ovarian tissue in an individual with a 46,XX karyotype and a wide phenotypic spectrum from female to male appearance. CASE PRESENTATION:We report ...

    journal_title:Hormone research in paediatrics

    pub_type:

    doi:10.1159/000503299

    authors: Pinti E,Piko H,Lengyel A,Luczay A,Karcagi V,Fekete G,Haltrich I

    更新日期:2019-01-01 00:00:00

  • Minipuberty: Why Does it Happen?

    abstract::Minipuberty describes the transient sex-specific activation of the hypothalamic-pituitary-gonadal (HPG) axis during the first 6 months of life in boys and during the first 2 years in girls. It leads to a rise of luteinizing hormone, follicle-stimulating hormone, estradiol, and testosterone. The existence of minipubert...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000508329

    authors: Becker M,Hesse V

    更新日期:2020-01-01 00:00:00

  • Thyroid Ultrasound: More Sensitive than Radioactive Iodine Imaging in Detecting Recurrence of Papillary Thyroid Cancer in Two Pediatric Patients.

    abstract:BACKGROUND:Papillary thyroid cancer (PTC) is an uncommon pediatric disease with an excellent prognosis. In follow-up surveillance, neck ultrasound (US), basal and thyroid-stimulating hormone-stimulated serum thyroglobulin (Tg) levels, and diagnostic whole-body radioactive iodine scans (DxWBS) have been traditionally us...

    journal_title:Hormone research in paediatrics

    pub_type:

    doi:10.1159/000487436

    authors: Wise-Oringer BK,Goldis M,Regelmann MO,Klein M,Machac J,Kotlus Rosenberg H,Rapaport R

    更新日期:2018-01-01 00:00:00

  • Influence of socioeconomic status and body mass index on bone age.

    abstract:BACKGROUND/AIMS:To evaluate the relationship of socioeconomic status (SES) and body mass index (BMI) with skeletal maturation in children from Marrakech (Morocco). METHODS:SES, BMI z-score and bone age (BA) were measured in a cohort of 623 children (280 boys and 343 girls, chronological age (CA) ranged from 6.6 to 18....

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000313371

    authors: Chaumoitre K,Lamtali S,Baali A,Saliba-Serre B,Lahmam A,Aboussad A,Boëtsch G,Panuel M

    更新日期:2010-01-01 00:00:00