Combined therapy with insulin and growth hormone in 17 patients with type-1 diabetes and growth disorders.

Abstract:

BACKGROUND/AIM:Combined growth hormone (GH) and insulin therapy is rarely prescribed by pediatric endocrinologists. We investigated the attitude of Italian physicians to prescribing that therapy in the case of short stature and type-1 diabetes (T1DM). METHODS:A questionnaire was sent and if a patient was identified, data on growth and diabetes management were collected. RESULTS:Data from 42 centers (84%) were obtained. Of these, 29 centers reported that the use of combined therapy was usually avoided. A total of 17 patients were treated in 13 centers (GH was started before T1DM onset in 9 patients and after the onset of T1DM in 8). Height SDS patterns during GH therapy in the 11 patients affected by GH deficiency ranged from -0.3 to +3.1 SDS. In the 8 diabetic patients in whom GH was added subsequently, mean insulin dose increased during the first 6 months of therapy from 0.7 ± 0.2 to 1.0 ± 0.2 U/kg (p = 0.004). HbA1c was unchanged during the first 6 months of combined therapy. CONCLUSIONS:Most Italian physicians do not consider prescribing the combined GH-insulin therapy in diabetic children with growth problems. However, the results of the 17 patients identified would confirm that the combined therapy was feasible and only caused mild insulin resistance. GH therapy was effective in promoting growth in most patients and did not affect diabetes metabolic control.

journal_name

Horm Res Paediatr

authors

Zucchini S,Iafusco D,Vannelli S,Rabbone I,Salzano G,Pozzobon G,Maghnie M,Cherubini V,Bizzarri C,Bonfanti R,D'Annunzio G,Lenzi L,Maggio MC,Marigliano M,Scaramuzza A,Tumini S,Iughetti L

doi

10.1159/000360856

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

53-8

issue

1

eissn

1663-2818

issn

1663-2826

pii

000360856

journal_volume

82

pub_type

杂志文章,多中心研究
  • Growth Hormone Improves Short-Term Growth in Patients with Temple Syndrome.

    abstract:BACKGROUND/AIMS:Temple syndrome is an imprinting disorder caused by maternal uniparental disomy of chromosome 14 (mat UPD14), paternal deletion of 14q32 or paternal hypomethylation of the intergenic differentially methylated region (MEG3/DLK1 IG-DMR). Patients with Temple syndrome have pre- and postnatal growth restric...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000496700

    authors: Brightman DS,Lokulo-Sodipe O,Searle BA,Mackay DJG,Davies JH,Temple IK,Dauber A

    更新日期:2018-01-01 00:00:00

  • Second Trimester Maternal Leptin Levels Are Associated with Body Mass Index and Gestational Weight Gain but not Birth Weight of the Infant.

    abstract:INTRODUCTION:Obesity is increasing among the pregnant population. Leptin has an important role in the regulation of energy balance and hunger. The aim of this study was to investigate the association between maternal leptin levels with maternal obesity, gestational weight gain (GWG), single nucleotide polymorphisms (SN...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000503422

    authors: Serapio S,Ahlsson F,Larsson A,Kunovac Kallak T

    更新日期:2019-01-01 00:00:00

  • Techniques in pediatric surgery: congenital hyperinsulinism.

    abstract::For surgery in congenital hyperinsulinism (CHI), a distinct strategy and technique is required for focal, diffuse and atypical types. In focal CHI, a confined, localized and parenchyma-sparing resection which is guided by the PET-CT is always indicated in order to cure the patient. In diffuse CHI, however, the results...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000321902

    authors: Barthlen W,Mohnike W,Mohnike K

    更新日期:2010-01-01 00:00:00

  • Congenital Hypothyroidism: 8-Year Experience Using 2 Newborn Screens in Alabama.

    abstract:BACKGROUND/AIMS:Newborn screening protocols for congenital hypothyroidism (CH) vary as to whether a TSH or T4 algorithm or some combination is performed. We aimed to determine the 3-year clinical outcome of infants diagnosed with CH and screen-positive for CH using a 2-screen protocol that measures both T4 and TSH on a...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000501395

    authors: Pitts L,McCormick W,Mick GJ

    更新日期:2019-01-01 00:00:00

  • Do the Anti-Müllerian Hormone Levels of Adolescents with Polycystic Ovary Syndrome, Those Who Are at Risk for Developing Polycystic Ovary Syndrome, and Those Who Exhibit Isolated Oligomenorrhea Differ from Those of Adolescents with Normal Menstrual Cycles

    abstract:BACKGROUND/AIMS:We aimed to investigate whether the anti-Müllerian hormone (AMH) levels in adolescents with polycystic ovary syndrome (PCOS), PCOS risk, and isolated oligomenorrhea (OM) were different than in adolescents with a normal/regular menstrual cycle (NMC). METHODS:The diagnosis of PCOS was based on the 2012 A...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000446111

    authors: Savas-Erdeve S,Keskin M,Sagsak E,Cenesiz F,Cetinkaya S,Aycan Z

    更新日期:2016-01-01 00:00:00

  • MKRN3 mutations in familial central precocious puberty.

    abstract::Loss-of-function mutations in the gene encoding the makorin RING finger protein 3 (MKRN3) have recently been reported to underlie familial cases of central precocious puberty (CPP). The imprinted MKRN3 gene is expressed only from the paternal allele, and mutations inherited from the father affect boys and girls equall...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000362815

    authors: Schreiner F,Gohlke B,Hamm M,Korsch E,Woelfle J

    更新日期:2014-01-01 00:00:00

  • IGF2 methylation is associated with lipid profile in obese children.

    abstract:AIM:Our aim was to investigate the relationships between the degree of IGF2 methylation and the metabolic status in obese children and adolescents. SUBJECTS AND METHODS:Eighty-five obese subjects aged 11.6 ± 2.1 years were studied. Anthropometry, metabolic parameters, blood pressure and body composition were assessed....

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000351707

    authors: Deodati A,Inzaghi E,Liguori A,Puglianiello A,Germani D,Brufani C,Fintini D,Cappa M,Barbetti F,Cianfarani S

    更新日期:2013-01-01 00:00:00

  • Elevated head circumference-to-height ratio is an early and frequent feature in children with neurofibromatosis type 1.

    abstract:BACKGROUND/AIMS:Children with neurofibromatosis type 1 (NF1) tend to be macrocephalic and short. Our aim was to define the incidence and diagnostic accuracy of elevated head circumference-to-height ratio (HCHR) in children with NF1 and to assess if elevated HCHR would facilitate early diagnosis of NF1. METHODS:Retrosp...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000347119

    authors: Karvonen M,Saari A,Hannila ML,Lönnqvist T,Dunkel L,Sankilampi U

    更新日期:2013-01-01 00:00:00

  • An Intron 9 CYP19 Gene Variant (IVS9+5G>A), Present in an Aromatase-Deficient Girl, Affects Normal Splicing and Is Also Present in Normal Human Steroidogenic Tissues.

    abstract:BACKGROUND/AIMS:Splicing CYP19 gene variants causing aromatase deficiency in 46,XX disorder of sexual development (DSD) patients have been reported in a few cases. A misbalance between normal and aberrant splicing variants was proposed to explain spontaneous pubertal breast development but an incomplete sex maturation ...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000437142

    authors: Saraco N,Nesi-Franca S,Sainz R,Marino R,Marques-Pereira R,La Pastina J,Perez Garrido N,Sandrini R,Rivarola MA,de Lacerda L,Belgorosky A

    更新日期:2015-01-01 00:00:00

  • Use of combined liothyronine and thyroxine therapy for consumptive hypothyroidism associated with hepatic haemangiomas in infancy.

    abstract::Hepatic haemiangiomas in infancy are rare. An association with hypothyroidism has been previously reported and is believed to be secondary to the conversion of thyroxine (fT4) to biologically inactive reverse triiodothyronine (rT3) by type 3 iodothyronine deiodinase (D3). We report a case that responded well to the co...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000281884

    authors: Peters C,Langham S,Mullis PE,Dattani MT

    更新日期:2010-01-01 00:00:00

  • Epidemiology of childhood type 1 diabetes mellitus: lessons from Central and Eastern European data.

    abstract:BACKGROUND:Over the past 15 years, the incidence of type 1 diabetes mellitus (T1DM) in Central and Eastern Europe has grown rapidly from an initially low rate. This growth cannot be attributed to genetic factors: it appears that changing environmental exposures are responsible, though no single environmental factor can...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000329168

    authors: Cinek O

    更新日期:2011-01-01 00:00:00

  • Continuous Intragastric Dextrose: A Therapeutic Option for Refractory Hypoglycemia in Congenital Hyperinsulinism.

    abstract::Feeding problems are frequent in infants with congenital hyperinsulinism (HI) and may be exacerbated by continuous enteral nutrition (EN) used to maintain euglycemia. Our center's HI team uses dextrose solution given continuously via gastric tube (intrasgastric dextrose, IGD) for infants not fully responsive to conven...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验

    doi:10.1159/000491105

    authors: Vajravelu ME,Congdon M,Mitteer L,Koh J,Givler S,Shults J,De León DD

    更新日期:2019-01-01 00:00:00

  • Two novel GATA6 mutations cause childhood-onset diabetes mellitus, pancreas malformation and congenital heart disease.

    abstract:BACKGROUND:GATA6 mutations are the most frequent cause of pancreatic agenesis and diabetes in human sporadic cases. In families, dominantly inherited mutations show a variable phenotype also in terms of endocrine and exocrine pancreatic disease. We report two novel GATA6 mutations in an independent cohort of 8 children...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000348844

    authors: Gong M,Simaite D,Kühnen P,Heldmann M,Spagnoli F,Blankenstein O,Hübner N,Hussain K,Raile K

    更新日期:2013-01-01 00:00:00

  • Thyroid Ultrasound: More Sensitive than Radioactive Iodine Imaging in Detecting Recurrence of Papillary Thyroid Cancer in Two Pediatric Patients.

    abstract:BACKGROUND:Papillary thyroid cancer (PTC) is an uncommon pediatric disease with an excellent prognosis. In follow-up surveillance, neck ultrasound (US), basal and thyroid-stimulating hormone-stimulated serum thyroglobulin (Tg) levels, and diagnostic whole-body radioactive iodine scans (DxWBS) have been traditionally us...

    journal_title:Hormone research in paediatrics

    pub_type:

    doi:10.1159/000487436

    authors: Wise-Oringer BK,Goldis M,Regelmann MO,Klein M,Machac J,Kotlus Rosenberg H,Rapaport R

    更新日期:2018-01-01 00:00:00

  • Prevalence of Metabolic Bone Disease in Tube-Fed Children Receiving Elemental Formula.

    abstract:BACKGROUND:Previous studies suggest normal mineral status in children receiving elemental formula. However, a recent multicenter survey described 51 children who developed hypophosphatemia and bone disease while receiving elemental formula. Our aim is to determine the prevalence of metabolic bone disease in children re...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000494726

    authors: Creo AL,Epp LM,Buchholtz JA,Tebben PJ

    更新日期:2018-01-01 00:00:00

  • Experience of Octreotide Therapy for Hyperinsulinemic Hypoglycemia in Neonates Born Small for Gestational Age: A Case Series.

    abstract:AIMS:Hyperinsulinemic hypoglycemia (HH) is common in small-for-gestational-age (SGA) neonates. Diazoxide is often used as the first-line medication for HH in SGA neonates. Unfortunately, diazoxide is not authorized in China. We examined the effectiveness of octreotide as an alternative therapy to treat HH in SGA neonat...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000441108

    authors: Pan S,Zhang M,Li Y

    更新日期:2015-01-01 00:00:00

  • Normative values for testicular volume measured by ultrasonography in a normal population from infancy to adolescence.

    abstract:BACKGROUND/AIMS:We obtained reference data for testicular volume measured by ultrasound in asymptomatic boys aged 0.5-18 years. In addition, we assessed the validity of the Prader orchidometer per age group by correlating it with the volume measurement by ultrasound. METHODS:The study only included healthy boys with t...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000326057

    authors: Goede J,Hack WW,Sijstermans K,van der Voort-Doedens LM,Van der Ploeg T,Meij-de Vries A,Delemarre-van de Waal HA

    更新日期:2011-01-01 00:00:00

  • Metabolic syndrome in children: comparison of the International Diabetes Federation 2007 consensus with an adapted National Cholesterol Education Program definition in 300 overweight and obese French children.

    abstract:BACKGROUND/AIMS:Former definitions of metabolic syndrome (MS) in children have been adapted from adult MS definitions using age-related thresholds for each biochemical component, whereas the International Diabetes Federation (IDF) definition is based on absolute values. We compared the IDF childhood MS definition (IDF-...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000284359

    authors: Druet C,Ong K,Levy Marchal C

    更新日期:2010-01-01 00:00:00

  • IL-6, IL-8 and IL-10 levels in healthy weight and overweight children.

    abstract:BACKGROUND/AIM:In adults, studies have shown that obesity is a chronic low-grade inflammatory state characterized by altered levels of cytokines. Studies in children have mainly focused on C-reactive protein and adiponectin, and there is limited data for other inflammatory markers in healthy weight and overweight child...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000277632

    authors: Tam CS,Garnett SP,Cowell CT,Heilbronn LK,Lee JW,Wong M,Baur LA

    更新日期:2010-01-01 00:00:00

  • The Diagnosis of Polycystic Ovary Syndrome during Adolescence.

    abstract:BACKGROUND/AIMS:The diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescence are controversial, primarily because the diagnostic pathological features used in adult women may be normal pubertal physiological events. Hence, international pediatric and adolescent specialty societies have defined criteria t...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000375530

    authors: Witchel SF,Oberfield S,Rosenfield RL,Codner E,Bonny A,Ibáñez L,Pena A,Horikawa R,Gomez-Lobo V,Joel D,Tfayli H,Arslanian S,Dabadghao P,Garcia Rudaz C,Lee PA

    更新日期:2015-04-01 00:00:00

  • Is adrenocorticotropic hormone deficiency really rare in patients with idiopathic growth hormone deficiency and normal thyroid function tests?

    abstract:BACKGROUND/AIM:It was the aim of this study to evaluate subtle adrenocorticotropic hormone deficiencies in a group of patients with idiopathic growth hormone deficiency and without thyroid-stimulating hormone deficiency. METHODS:Growth hormone and cortisol responses to an insulin tolerance test of 25 patients (15 male...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000320479

    authors: Savas Erdeve S,Ocal G,Berberoglu M,Siklar Z,Hacihamdioglu B

    更新日期:2011-01-01 00:00:00

  • IGF1, IGF1R and SHOX mutation analysis in short children born small for gestational age and short children with normal birth size (idiopathic short stature).

    abstract:BACKGROUND/AIMS:Because the criteria for genetic screening of short children are unknown, we performed genetic analysis of 199 short children born small for gestational age (SGA) or with normal birth size (idiopathic short stature, ISS). METHODS:After selection with a modified scoring system for SHOX and a novel score...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000338341

    authors: Caliebe J,Broekman S,Boogaard M,Bosch CA,Ruivenkamp CA,Oostdijk W,Kant SG,Binder G,Ranke MB,Wit JM,Losekoot M

    更新日期:2012-01-01 00:00:00

  • A Novel GNAS Mutation Causing Isolated Infantile Cushing's Syndrome.

    abstract::Infantile Cushing's syndrome is potentially found as part of McCune-Albright syndrome (MAS) which is caused by postzygotic somatic mutations of the GNAS gene. MAS is typically characterized by a triad of polyostotic fibrous dysplasia, café-au-lait skin pigmentation, and precocious puberty or other endocrine hyperfunct...

    journal_title:Hormone research in paediatrics

    pub_type:

    doi:10.1159/000501169

    authors: Dejkhamron P,Ittiwut C,TangNgam H,Sunkonkit K,Natesirinilkul R,Suphapeetiporn K,Shotelersuk V

    更新日期:2019-01-01 00:00:00

  • Adult height and epigenotype in children with Silver-Russell syndrome treated with GH.

    abstract:AIMS:To compare adult heights of GH-treated and GH-untreated patients with Silver-Russell syndrome (SRS) who were epigenotyped. METHODS:This was a nonrandomized retrospective study with matched controls at a single center. Molecular analysis of 32 out of 37 GH-treated patients (16 females) revealed IGF2-H19 epimutatio...

    journal_title:Hormone research in paediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1159/000354658

    authors: Binder G,Liebl M,Woelfle J,Eggermann T,Blumenstock G,Schweizer R

    更新日期:2013-01-01 00:00:00

  • Thyroid function patterns at Hashimoto's thyroiditis presentation in childhood and adolescence are mainly conditioned by patients' age.

    abstract:BACKGROUND:There are few studies investigating the factors which may affect different biochemical presentations of Hashimoto's thyroiditis (HT) and these are frequently based on limited pediatric populations. AIMS:(1) To assess the frequency of thyroid function patterns at HT diagnosis in 608 children and adolescents,...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000343815

    authors: Wasniewska M,Corrias A,Salerno M,Mussa A,Capalbo D,Messina MF,Aversa T,Bombaci S,De Luca F,Valenzise M

    更新日期:2012-01-01 00:00:00

  • Improvements in behaviour and self-esteem following growth hormone treatment in short prepubertal children.

    abstract:BACKGROUND/AIMS:To evaluate effects of growth hormone (GH) treatment on behaviour and psychosocial characteristics in short-stature children. METHODS:99 referred prepubertal non-familiar short-stature children (32 GH deficiency; 67 idiopathic short stature) aged 3-11 years, randomized to fixed or individual GH doses a...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1159/000322937

    authors: Chaplin JE,Kriström B,Jonsson B,Hägglöf B,Tuvemo T,Aronson AS,Dahlgren J,Albertsson-Wikland K

    更新日期:2011-01-01 00:00:00

  • Reversible Growth Hormone Excess in Two Girls with Neurofibromatosis Type 1 and Optic Pathway Glioma.

    abstract:BACKGROUND:A total of 12 children with neurofibromatosis type 1 (NF-1) with optic pathway glioma (OPG) and growth hormone (GH) excess are reported to date, but no data exist on the long-term outcome. We describe 2 girls with NF-1 with OPG and GH excess treated with somatostatin analogue (SSa) who maintained a normal GH...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000440956

    authors: Bruzzi P,Sani I,Albanese A

    更新日期:2015-01-01 00:00:00

  • A new horizon for glucose monitoring.

    abstract::Regular self-monitoring of blood glucose is crucial for proper insulin dosing and gives a reliable foundation for reasonable glycaemic control. According to recent data, recommended values for glycated haemoglobin A1c as set by the professional associations remain out of the reach for a large proportion of the paediat...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000368924

    authors: Dovč K,Bratina N,Battelino T

    更新日期:2015-01-01 00:00:00

  • Multiple factors influencing the incidence of congenital hypothyroidism detected by neonatal screening.

    abstract:BACKGROUND/AIMS:Over the years a rise in the incidence of congenital hypothyroidism (CH) has been described worldwide. The aim of our study was to investigate trends in the incidence of CH in Italy over the period 1987-2008, and to investigate which factors may have influenced the CH incidence in our country. METHODS:...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章

    doi:10.1159/000369394

    authors: Olivieri A,Fazzini C,Medda E,Italian Study Group for Congenital Hypothyroidism.

    更新日期:2015-01-01 00:00:00

  • Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children.

    abstract::The rising incidence of obesity and metabolic diseases such as diabetes mellitus and cardiovascular disease in adolescents and young adults is of grave concern. Recent studies favor a role of lifestyle factors over genetics in the perpetuation of inflammation, insulin resistance and oxidative stress, which are pathoph...

    journal_title:Hormone research in paediatrics

    pub_type: 杂志文章,评审

    doi:10.1159/000444053

    authors: Gupta A,Uribarri J

    更新日期:2016-01-01 00:00:00