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Fast intraoperative testosterone assay confirms the location of an ovarian virilizing tumor in a young girl.

Abstract：

:The detection of testosterone-producing ovarian tumors in childhood and adolescence by imaging techniques only can be difficult because of the tumors' radiological structure and sometimes diminutive size. We describe an 11.5-year-old girl with a 9-month history of voice deepening, mild hirsutism, minor acne, increased growth velocity, weight gain, and clitoromegaly. Laboratory investigation revealed an extremely elevated serum testosterone level without any additional endocrine abnormalities. Abdominal ultrasound and MRI showed a sparsely noticeable solid mass in the center of the right ovary. At laparotomy, blood was selectively drawn from the right and the left ovarian veins. Rapid testosterone measurement revealed a 70-fold higher testosterone concentration in the right ovarian vein within 45 min. Based on this finding, a right salpingo-oophorectomy was performed. The patient's postoperative testosterone level declined within 24 h. The histopathological diagnosis was Leydig cell tumor. In conclusion, the implementation of a fast intraoperative testosterone assay enabled the localization and curative therapy of a Leydig cell tumor. This technique seems to be a good alternative to preoperative selective venous blood sampling when body imaging does not unveil the tumor's site.

journal_name

Horm Res Paediatr

journal_title

Hormone research in paediatrics

authors

Braun R,Peter A,Warmann S,Fuchs J,Binder G

doi

10.1159/000339683

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

110-3

issue

2

eissn

1663-2818

issn

1663-2826

pii

000339683

journal_volume

79

pub_type

杂志文章

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