Stem cell source and outcome after hematopoietic stem cell transplantation (HSCT) in children and adolescents with acute leukemia.

Abstract:

:Allogeneic hematopoietic stem cell transplantation from siblings, unrelated donors or HLA mismatched family members has become an important procedure to offer a chance of cure to children and adolescents with acute leukemia at high risk of relapse and those with certain genetic diseases. Bone marrow (BM) was the only stem cell source for many years. During the past 15 years, peripheral blood stem cells from granulocyte colony-stimulating factor (G-CSF) mobilized healthy donors, or umbilical cord blood from related or unrelated donors, have become available. Each stem cell source has different risks/benefits for patients and donors, the choice depending not only on availability, but also on HLA compatibility and urgency of the HSCT. This review will analyze the advantages and limitations of each of these options, and the main criteria which can be applied when choosing the appropriate stem cell source for pediatric transplant recipients with acute leukemia.

journal_name

Pediatr Clin North Am

authors

Peters C,Cornish JM,Parikh SH,Kurtzberg J

doi

10.1016/j.pcl.2010.01.004

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

27-46

issue

1

eissn

0031-3955

issn

1557-8240

pii

S0031-3955(10)00005-2

journal_volume

57

pub_type

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