Abstract:
:Allogeneic hematopoietic stem cell transplantation from siblings, unrelated donors or HLA mismatched family members has become an important procedure to offer a chance of cure to children and adolescents with acute leukemia at high risk of relapse and those with certain genetic diseases. Bone marrow (BM) was the only stem cell source for many years. During the past 15 years, peripheral blood stem cells from granulocyte colony-stimulating factor (G-CSF) mobilized healthy donors, or umbilical cord blood from related or unrelated donors, have become available. Each stem cell source has different risks/benefits for patients and donors, the choice depending not only on availability, but also on HLA compatibility and urgency of the HSCT. This review will analyze the advantages and limitations of each of these options, and the main criteria which can be applied when choosing the appropriate stem cell source for pediatric transplant recipients with acute leukemia.
journal_name
Pediatr Clin North Amjournal_title
Pediatric clinics of North Americaauthors
Peters C,Cornish JM,Parikh SH,Kurtzberg Jdoi
10.1016/j.pcl.2010.01.004subject
Has Abstractpub_date
2010-02-01 00:00:00pages
27-46issue
1eissn
0031-3955issn
1557-8240pii
S0031-3955(10)00005-2journal_volume
57pub_type
杂志文章,评审abstract::With the recent mandate for early intervention services, the pediatrician is more involved than ever in the identification and evaluation of children with developmental disabilities. Developmental surveillance at routine visits and listening to parental concerns are crucial in the early diagnosis of developmental dela...
journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
pub_type: 杂志文章,评审
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journal_title:Pediatric clinics of North America
pub_type: 杂志文章,评审
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
pub_type: 杂志文章,评审
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journal_title:Pediatric clinics of North America
pub_type: 杂志文章,评审
doi:10.1016/s0031-3955(16)36506-3
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journal_title:Pediatric clinics of North America
pub_type: 杂志文章
doi:10.1016/s0031-3955(16)34509-6
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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journal_title:Pediatric clinics of North America
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