Clinical and preclinical evidence of somatosensory involvement in amyotrophic lateral sclerosis.

abstract：:1. The concentrations of adrenaline and noradrenaline in the brains of chickens (Gallus domesticus) have been determined using two different methods of fluorimetric analysis.2. The concentrations of adrenaline, noradrenaline and also dopamine were found to increase with age, as did the relative amount of adrenaline pr...

journal_title：British journal of pharmacology

authors： Callingham BA,Sharman DF

更新日期：1970-09-01 00:00:00

abstract：:1. The effects of beta-adrenoceptor blockade on the changes in plasma renin activity (PRA) following angiotensin enzyme (ACE) inhibition were investigated in pentobarbitone-chloralose anaesthetized dogs. 2. ACE-inhibition, with enalapril (2 mg kg-1), caused a significant reduction in systemic arterial blood pressure (...

journal_title：British journal of pharmacology

authors： Cambridge D,Whiting MV,Butterfield LJ,Allan G

更新日期：1992-06-01 00:00:00

abstract：UNLABELLED:Sarcoplasmic reticular (SR) Ca(2+) -ATPase (SERCA2a) is central to cardiac electrophysiological and mechanical function. It ensures full diastolic relaxation minimizing delayed after-potentials that would otherwise compromise membrane electrophysiological stability, and optimizes SR Ca(2+) refilling and syst...

journal_title：British journal of pharmacology

authors： Huang CL

更新日期：2013-10-01 00:00:00

abstract：:1. In order to investigate the vasodilator mechanisms of the K+ channel openers, cromakalim, pinacidil and nicorandil, we measured changes in cytoplasmic Ca2+ concentration [( Ca2+]i) simultaneously with force by a microfluorimetric method using fura-2, a calcium indicator, in canine coronary arterial smooth muscle ce...

journal_title：British journal of pharmacology

authors： Yanagisawa T,Teshigawara T,Taira N

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Airway remodelling is a consequence of long-term inflammation and MAPKs are key signalling molecules that drive pro-inflammatory pathways. The endogenous MAPK deactivator--MAPK phosphatase 1 (MKP-1)--is a critical negative regulator of the myriad pro-inflammatory pathways activated by MAPKs in th...

journal_title：British journal of pharmacology

authors： Manetsch M,Ramsay EE,King EM,Seidel P,Che W,Ge Q,Hibbs DE,Newton R,Ammit AJ

更新日期：2012-08-01 00:00:00

abstract：:Intraperitoneal and intracerebral injections of methyl beta-carboline-3-carboxylate (beta CCM) and intracerebral injections of RO 15-1788 were given to rats. The performance of the rats in the social interaction test was measured to determine if changes in social interaction induced by beta CCM were mediated in part b...

journal_title：British journal of pharmacology

authors： Hindley SW,Hobbs A,Paterson IA,Roberts MH

更新日期：1985-11-01 00:00:00

abstract：:1. Morphine, oxotremorine and physostigmine showed antinociceptive activity in mice using the hot plate reaction time test.2. The action of morphine, but not that of oxotremorine, was antagonized by naloxone and by nalorphine, whereas the effect of physostigmine was unaffected by naloxone and increased by nalorphine.3...

journal_title：British journal of pharmacology

authors： Pleuvry BJ,Tobias MA

更新日期：1971-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Muscarinic toxins (MTs) are snake venom peptides named for their ability to interfere with ligand binding to muscarinic acetylcholine receptors (mAChRs). Recent data infer that these toxins may have other G-protein-coupled receptor targets than the mAChRs. The purpose of this study was to systema...

journal_title：British journal of pharmacology

authors： Näreoja K,Kukkonen JP,Rondinelli S,Toivola DM,Meriluoto J,Näsman J

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:There is increasing evidence that potassium channels are involved in the cardiovascular dysfunction of sepsis. This evidence was obtained after the systemic inflammation, cardiovascular dysfunction and organ damage had developed. Here we have studied the consequences of early interference with po...

journal_title：British journal of pharmacology

authors： Sordi R,Fernandes D,Heckert BT,Assreuy J

更新日期：2011-07-01 00:00:00

abstract：:1. Alterations of 5-hydroxytryptaminergic mechanisms are thought to play a special role in the pathogenesis of depression and antidepressant treatments are assumed to restore these changes. 2. We have used one of the most reliable models of depression, the olfactory bulbectomized rat to study the long term consequence...

journal_title：British journal of pharmacology

authors： Grecksch G,Zhou D,Franke C,Schröder U,Sabel B,Becker A,Huether G

更新日期：1997-12-01 00:00:00

abstract：:1. We have studied the effect of cannabinoid agonists (CP 55,940 and cannabinol) on intestinal motility in a model of intestinal inflammation (induced by oral croton oil in mice) and measured cannabinoid receptor expression, endocannabinoids (anandamide and 2-arachidonylglycerol) and anandamide amidohydrolase activity...

journal_title：British journal of pharmacology

authors： Izzo AA,Fezza F,Capasso R,Bisogno T,Pinto L,Iuvone T,Esposito G,Mascolo N,Di Marzo V,Capasso F

更新日期：2001-10-01 00:00:00

abstract：:1 Very highly purified (greater than 100,000 u/mg) slow reacting substance of anaphylaxis (SRS-A) has been prepared by reversed phase high pressure liquid chromatographic (HPLC) techniques. 2 High resolution liquid chromatography suggests that SRS-A may exist in at least three distinct forms which are possible tautome...

journal_title：British journal of pharmacology

authors： Blackwell GJ,Burka JF,Flower RJ,Torkington P

更新日期：1980-01-01 00:00:00

abstract：LINKED ARTICLES:This article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc. ...

journal_title：British journal of pharmacology

authors： Stanford SC

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Xaliproden (SR57746A) is a 5-HT(1A) receptor agonist and neurotrophic agent that reduces oxaliplatin-mediated neuropathy in clinical trials. The present study investigated its profile on in vitro transduction, neurochemical responses and acute nociceptive pain tests in rats. EXPERIMENTAL APPROAC...

journal_title：British journal of pharmacology

authors： Martel JC,Assié MB,Bardin L,Depoortère R,Cussac D,Newman-Tancredi A

更新日期：2009-09-01 00:00:00

abstract：:1 Endomorphin-1 and -2 (E-1/E-2) have been proposed as endogenous ligands for the mu-opioid receptor. The aims of this study are to characterize the binding of E-1/E-2 and the subsequent effects on cyclic AMP formation and [Ca2+]i levels in SH-SY5Y and Chinese hamster ovary (CHO) cells expressing endogenous and recomb...

journal_title：British journal of pharmacology

authors： Harrison C,McNulty S,Smart D,Rowbotham DJ,Grandy DK,Devi LA,Lambert DG

更新日期：1999-09-01 00:00:00

abstract：:1. Moclobemide (MB) is an antidepressant drug that selectively and reversibly inhibits monoamine oxidase-A. Recent studies have revealed that antidepressant drugs possess the characters of potent growth-promoting factors for the development of neurogenesis and improve the survival rate of serotonin (5-hydroxytrytamine...

journal_title：British journal of pharmacology

authors： Chiou SH,Ku HH,Tsai TH,Lin HL,Chen LH,Chien CS,Ho LL,Lee CH,Chang YL

更新日期：2006-07-01 00:00:00

abstract：:1. The current study investigated the effects of respiratory tract viral infection on the density of ETA and ETB receptors in murine tracheal smooth muscle and on the contractile response to endothelin-1 mediated by these receptors. 2. Quantitative autoradiographic studies using [125I]-endothelin-1 revealed that trach...

journal_title：British journal of pharmacology

authors： Henry PJ,Goldie RG

更新日期：1994-08-01 00:00:00

abstract：:Constitutively active mu-opioid receptors (mu* receptors) are reported to be formed following prolonged agonist treatment of cells or whole animals. mu* receptors signal in the absence of activating ligand and a blockade of mu* activation of G-proteins by naloxone and naltrexone has been suggested to underlie the prof...

journal_title：British journal of pharmacology

authors： Connor M

更新日期：2009-04-01 00:00:00

abstract：:We utilized a rat model of myocardial infarction to investigate whether manganese superoxide dismutase (Mn-SOD), an intrinsic radical scavenger, and tumour necrosis factor- alpha (TNF-alpha) and/or interleukin-1beta (IL-1beta) are involved in the late phase of ischaemic preconditioning (IP). IP was induced in anaesthe...

journal_title：British journal of pharmacology

authors： Yamashita N,Hoshida S,Otsu K,Taniguchi N,Kuzuya T,Hori M

更新日期：2000-10-01 00:00:00

abstract：:1. The pulmonary vasculature is constantly exposed to oxygen and reactive oxygen species such as nitric oxide (NO) and superoxide anions which can combine at a near diffusion limited rate, to form the powerful, oxidant, peroxynitrite (ONOO-). When formed in large amounts, ONOO- is thought to contribute to tissue injur...

journal_title：British journal of pharmacology

authors： Chabot F,Mitchell JA,Quinlan GJ,Evans TW

更新日期：1997-06-01 00:00:00

abstract：:This article discusses the background to the need for change in the reporting of experiments involving animals, including a report of a consensus meeting organised by the Basel Declaration Society and Understanding Animal Research UK that sought to Internationalise guidelines for reporting experiments involving animal...

journal_title：British journal of pharmacology

authors： McGrath JC,McLachlan EM,Zeller R

更新日期：2015-05-01 00:00:00

abstract：:Ischaemia is amongst the leading causes of death. Despite this importance, there are only a few therapeutic approaches to protect from ischaemia-reperfusion injury (IRI). In experimental studies, the amino acid glycine effectively protected from IRI. In the prevention of IRI by glycine in cells and isolated perfused o...

journal_title：British journal of pharmacology

authors： Petrat F,Boengler K,Schulz R,de Groot H

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The sonic hedgehog pathway (Shh) plays a central role in maintaining stem cell function and behaviour in various processes related to self-renewal and tissue regeneration. However, the therapeutic effect of Shh on mouse embryonic stem cells (mESCs) has not yet been clearly elucidated. Thus, we in...

journal_title：British journal of pharmacology

authors： Oh JY,Suh HN,Choi GE,Lee HJ,Jung YH,Ko SH,Kim JS,Chae CW,Lee CK,Han HJ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The type-5 PDE inhibitor vardenafil reduces myocardial infarct size in situ, following ischemia/reperfusion, when applied at reperfusion in animal models. Little is known about the underlying protective signaling. Here, we test whether vardenafil is protective in rat isolated hearts and in a cell...

journal_title：British journal of pharmacology

authors： Maas O,Donat U,Frenzel M,Rütz T,Kroemer HK,Felix SB,Krieg T

更新日期：2008-05-01 00:00:00

abstract：:1. Microfluorimetry techniques with fura-2 were used to characterize the effects of efaroxan (200 microM), phenotolamine (200-500 microM) and idazoxan (200-500 microM) on the intracellular free Ca2+ concentration ([Ca2+]i) in mouse isolated islets of Langerhans. 2. The imidazoline receptor agonists efaroxan and phento...

journal_title：British journal of pharmacology

authors： Shepherd RM,Hashmi MN,Kane C,Squires PE,Dunne MJ

更新日期：1996-11-01 00:00:00

abstract：:1. The actions of bretylium tosylate on neuromuscular transmission in the rat phrenic nerve diaphragm preparation have been investigated by electro-2. On the guinea-pig ileum, threshold doses elicit repeated maximal spike contractions which are blocked by atropine. In the presence of atropine, higher concentrations of...

journal_title：British journal of pharmacology

authors： Clineschmidt BV,Geller RG,Govier WC,Pisano JJ,Tanimura T

更新日期：1971-04-01 00:00:00

abstract：:In the present study we used a bioassay to study the effects of peroxynitrite (ONOO-) on angiotensin II (A-II)-triggered tension in isolated bovine coronary arteries in order to show the consequences of the previously reported PGI2-synthase inhibition by ONOO- in this model. The following results were obtained: 1. 1 m...

journal_title：British journal of pharmacology

authors： Zou M,Jendral M,Ullrich V

更新日期：1999-03-01 00:00:00

abstract：:1. A pentobarbitone-anaesthetized canine model of myocardial conduction was developed to evaluate drug effects on intra-atrial (I-A), intra-ventricular (I-V) and atrioventricular (A-V) conduction parameters, both at rest and during electrical pacing of the right atrium or ventricle. Drug effects on the ability of the ...

journal_title：British journal of pharmacology

authors： Allely MC,Alps BJ

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Volume-regulated anion channels (VRACs) play an important role in cell-volume regulation. alpha(1)-Adrenoceptor stimulation by phenylephrine (PE) suppressed the hypotonic activation of VRAC current in mouse ventricular cells and regulatory volume decrease (RVD) was also absent in PE-treated cells...

journal_title：British journal of pharmacology

authors： Ichishima K,Yamamoto S,Iwamoto T,Ehara T

更新日期：2010-09-01 00:00:00

abstract：:Three genes encode the small-conductance Ca(2+)-activated K(+) channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the pharmacology of these subtypes using whole-cell patch clamp recordings. The bee venom peptide apamin blocked hSK1 as well as rSK2 with IC(50) values of 3.3 nM...

journal_title：British journal of pharmacology

authors： Strøbaek D,Jørgensen TD,Christophersen P,Ahring PK,Olesen SP

更新日期：2000-03-01 00:00:00