Gastrointestinal alterations in autism spectrum disorder: What do we know?

Abstract:

:There is an emerging body of evidence associating children having autism spectrum disorder (ASD) with gastrointestinal (GI) symptoms, such as abdominal pain, chronic diarrhea, constipation, vomiting, gastroesophageal reflux, intestinal infections, and increased intestinal permeability. Moreover, in many studies, large differences in the composition of intestinal microbiota and metabolic products between ASD patients and controls were reported. Deepening the role and the biology of the gut microbiome may be fundamental to elucidate the onset of GI symptoms in ASD individuals and their etiopathogenetic causes. The gut-brain axis may affect brain development and behaviors through the neuroendocrine, neuroimmune, and autonomic nervous systems.

journal_name

Neurosci Biobehav Rev

authors

Bjørklund G,Pivina L,Dadar M,Meguid NA,Semenova Y,Anwar M,Chirumbolo S

doi

10.1016/j.neubiorev.2020.06.033

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

111-120

eissn

0149-7634

issn

1873-7528

pii

S0149-7634(20)30460-7

journal_volume

118

pub_type

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