Abstract:
:The human Y chromosome consists of ampliconic genes, which are located in palindromes and undergo frequent gene conversion, and single-copy genes including the primary sex-determining locus, SRY. Here, we demonstrate that SRY is duplicated in a large palindrome in the European rabbit (Oryctolagus cuniculus). Furthermore, we show through comparative sequencing that orthologous palindrome arms have diverged 0.40% between rabbit subspecies over at least 2 My, but paralogous palindrome arms have remained nearly identical. This provides clear evidence of gene conversion on the rabbit Y chromosome. Together with previous observations in humans, these results suggest that gene conversion is a general feature of the evolution of the mammalian Y chromosome.
journal_name
Mol Biol Evoljournal_title
Molecular biology and evolutionauthors
Geraldes A,Rambo T,Wing RA,Ferrand N,Nachman MWdoi
10.1093/molbev/msq139subject
Has Abstractpub_date
2010-11-01 00:00:00pages
2437-40issue
11eissn
0737-4038issn
1537-1719pii
msq139journal_volume
27pub_type
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