[Prevalence of HIV-1 subtypes in patients of an urban center in Southern Brazil].

Abstract:

OBJECTIVE:To estimate the prevalence of HIV-1 subtypes and analyze factors associated. METHODS:A cross-sectional study was performed with a convenience sample of 80 adult HIV-positive patients, users of an AIDS/STD specialized service, in the city of Canoas, Southern Brazil, between July 2008 and January 2009. Determination of HIV subtypes was performed with the amplification of viral genome fragment, using polymerase chain reaction, followed by sequencing of the amplified fragments. Sociodemographic, clinical and behavioral variables were collected in a structured questionnaire. Univariate statistical analysis was performed, using chi-square test and Student's t-test. RESULTS:A higher prevalence of subtype C was found (43.8%; 95% CI: 32.9;54.6), followed by CRF31_BC (35.0%; 95% CI: 24.6;45.5) and subtypes B (18.8%; 95% CI: 10.2;27.3) and F (2.4%; 95% CI: 0;5.9). Other HIV-1 subtypes were not observed. Patients infected with CRF31_BC were diagnosed more recently than patients infected with subtype B (p<0.05). In addition, there was a higher frequency of co-infection with other viruses (hepatitis B and C and human T-lymphotropic viruses) in individuals with CRF31_BC, compared to other subtypes. With regard to sociodemographic aspects, there were no differences in the distribution of subtypes and recombinant forms, in terms of gender and sexual practices. CONCLUSIONS:Results obtained indicate a higher frequency of subtype C and CRF31_BC in this urban center of Southern Brazil, with possible different ways of transmission.

journal_name

Rev Saude Publica

journal_title

Revista de saude publica

authors

Simon D,Béria JU,Tietzmann DC,Carli Rd,Stein AT,Lunge VR

doi

10.1590/s0034-89102010005000039

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1094-101

issue

6

eissn

0034-8910

issn

1518-8787

pii

S0034-89102010005000039

journal_volume

44

pub_type

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