Abstract：
:Polychlorinated biphenyls (PCBs) are infamous industry by-products or additives, and increasing evidences demonstrated that their exposure is associate with adverse effects on human health. Liver, as the dominate site for xenobiotic metabolism, is apt to be the primary target of PCBs insult. Although PCBs' hepatic toxic effects have been extensively studied, however, the biotransformation of PCBs in liver and the toxicities of associated PCB metabolites are neglected at some extent. Thus, we choose 2,3,5-trichloro-6-phenyl-[1,4]-benzoquinone (PCB29-pQ), a surrogate PCB29 metabolite, and evaluated its contribution on hepatotoxicity. In the current study, we discovered PCB29-pQ-induced lipid peroxidation and iron overload both in vivo and in vitro. Further mechanistic research confirmed iron overload is caused by reactive oxygen species (ROS)-driven hepcidin disorder in hepatic cells, and the increase of hepcidin is regulated by the translocation of nuclear factor erythroid 2-related factor 2 (Nrf2).
journal_name
Environ Intjournal_title
Environment internationalauthors
Liu J,Tan Y,Yang B,Wu Y,Fan B,Zhu S,Song E,Song Ydoi
10.1016/j.envint.2020.105701subject
Has Abstractpub_date
2020-06-01 00:00:00pages
105701eissn
0160-4120issn
1873-6750pii
S0160-4120(19)34875-5journal_volume
139pub_type
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