Abstract:
:A reliable quantification of the potential effects of chemicals on freshwater ecosystems requires ecotoxicological response data for a large set of species which is typically not available in practice. In this study, we propose a method to estimate hazardous concentrations (HCs) of chemicals on freshwater ecosystems by combining two in silico approaches: quantitative structure activity relationships (QSARs) and interspecies correlation estimation (ICE) models. We illustrate the principle of our QSAR-ICE method by quantifying the HCs of 51 chemicals at which 50% and 5% of all species are exposed above the concentration causing acute effects. We assessed the bias of the HCs, defined as the ratio of the HC based on measured ecotoxicity data and the HC based on in silico data, as well as the statistical uncertainty, defined as the ratio of the 95th and 5th percentile of the HC. Our QSAR-ICE method resulted in a bias that was comparable to the use of measured data for three species, as commonly used in effect assessments: the average bias of the QSAR-ICE HC50 was 1.2 and of the HC5 2.3 compared to 1.2 when measured data for three species were used for both HCs. We also found that extreme statistical uncertainties (>105) are commonly avoided in the HCs derived with the QSAR-ICE method compared to the use of three measurements with statistical uncertainties up to 1012. We demonstrated the applicability of our QSAR-ICE approach by deriving HC50s for 1,223 out of the 3,077 organic chemicals of the USEtox database. We conclude that our QSAR-ICE method can be used to determine HCs without the need for additional in vivo testing to help prioritise which chemicals with no or few ecotoxicity data require more thorough assessment.
journal_name
Environ Intjournal_title
Environment internationalauthors
Douziech M,Ragas AMJ,van Zelm R,Oldenkamp R,Jan Hendriks A,King H,Oktivaningrum R,Huijbregts MAJdoi
10.1016/j.envint.2019.105334subject
Has Abstractpub_date
2020-01-01 00:00:00pages
105334eissn
0160-4120issn
1873-6750pii
S0160-4120(19)32911-3journal_volume
134pub_type
杂志文章abstract::Soil amendment with biochars is currently being studied worldwide as a sustainable agricultural practice to improve soil and water quality, increase crop productivity, and augment soil carbon storage. However, the formation of polyaromatic hydrocarbons (PAHs) during biochar production is inevitable. Therefore, it is c...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.06.009
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Blood lead levels (BLLs) were measured in the adult Inuit population of Nunavut, Northern Canada, during the Inuit Health Survey (IHS) in 2007-2008. Approximately 10% of the adult participants had BLL over the Health Canada's guidance of 100μg/L. OBJECTIVES:1) To repeat the measurement of BLL among the IHS ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.06.004
更新日期:2014-10-01 00:00:00
abstract::Decision making for zoonotic disease management should be based on many forms of appropriate data and sources of evidence. However, the criteria and timing for policy response and the resulting management decisions are often altered when a disease outbreak occurs and captures full media attention. In the case of water...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2011.11.006
更新日期:2012-04-01 00:00:00
abstract::Cadmium exposure is associated with increased urinary calcium excretion. Hypercalciuria is recognised as a major risk factor for kidney stone formation. Increased prevalence of kidney stones among those occupationally exposed to cadmium has previously been suggested. Food is the main source of cadmium exposure in the ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.06.008
更新日期:2013-09-01 00:00:00
abstract::Arsenic (As) is mobilized from delta and floodplain aquifer sediments throughout S.E. Asia via reductive dissolution of As bound to iron (Fe) oxyhydroxides. The reductive driving force is organic carbon, but its source and constitution is uncertain. Here batch incubation experiments were conducted to investigate the r...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2008.07.024
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Residential green and blue spaces may be therapeutic for the mental health. However, solid evidence on the linkage between exposure to green and blue spaces and mental health among the elderly in non-Western countries is scarce and limited to exposure metrics based on remote sensing images (i.e., land cover ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.02.013
更新日期:2019-05-01 00:00:00
abstract::Microplastics are particles smaller than five millimeters deriving from the degradation of plastic objects present in the environment. Microplastics can move from the environment to living organisms, including mammals. In this study, six human placentas, collected from consenting women with physiological pregnancies, ...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2020.106274
更新日期:2021-01-01 00:00:00
abstract::Production system-related air pollution emissions are dominant components in global emission reduction targets and in realizing relevant sustainable development goals (SDGs). To better understand the air pollution emissions induced by globalized production systems through a life cycle perspective, environmental extend...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.104996
更新日期:2019-10-01 00:00:00
abstract::Exposure to surface ozone (O3), which is influenced by emissions of precursor chemical species, meteorology and population distribution, is associated with excess mortality and respiratory morbidity. In this study, the EMEP-WRF atmospheric chemistry transport model was used to simulate surface O3 concentrations at 5km...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.09.010
更新日期:2013-11-01 00:00:00
abstract::It is becoming increasingly clear that the genetic diversity and abundance of antimicrobial resistance (AMR) in non-clinical settings has been underestimated and that the environment plays an integral role in enabling the development of AMR. Due to specific demographic and environmental factors the Gulf Cooperation Co...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2018.06.030
更新日期:2018-12-01 00:00:00
abstract::Reservoirs play a vital role in the control and management of surface water resources. However, the long water residence time in the reservoir potentially increases the storage and accumulation of antibiotic resistant genes (ARGs). The full profiles and potential health risks of antibiotic resistomes in reservoirs are...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105449
更新日期:2020-03-01 00:00:00
abstract::Humic substances (HS) and natural organic matter (NOM) are natural organic compounds ubiquitous in the environment. However, some studies indicate that both HS and NOM can act as xenobiotics, e.g. induce hormone-like effects in fish, amphibians and invertebrates. Molecules of these substances contain a number of aroma...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2007.03.011
更新日期:2007-08-01 00:00:00
abstract::Recently, PM2.5 (atmospheric fine particulate matter with aerodynamic diameter ≤ 2.5 μm) have received so much attention that the observations, source appointment and countermeasures of it have been widely studied due to its harmful impacts on visibility, mood (mental health), physical health, traffic safety, construc...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2015.10.016
更新日期:2016-01-01 00:00:00
abstract::Environmental surveillance of antibiotics and antibiotic resistance could contribute toward the protection of human, animal and ecosystem health. However, justification for the choice of markers and sampling sites that informs about different risk scenarios is often lacking. Here, we define five fundamentally differen...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.05.074
更新日期:2019-09-01 00:00:00
abstract::Being persistent, toxic, and bio-accumulative, Mercury (Hg) seriously affects the environment and human health. Due to Hg's attribute of long-range environmental transport across national borders, especially through atmospheric transport, no country can fully protect its environment and human health with its own effor...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.10.023
更新日期:2015-02-01 00:00:00
abstract::Methylmercury (MeHg) poses health risks to humans worldwide. The investigation of a longer chain of biogeochemical MeHg transport from production to consumption than that addressed in previous studies could provide additional scientific foundation for the reduction of risks. The main objective of this study is to iden...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105392
更新日期:2020-02-01 00:00:00
abstract::Previous epidemiological studies primarily examined the temperature-related mortality burden of all-cause or cardiovascular diseases (CVD) and respiratory diseases. However, evidence on the heat- and cold-attributable mortality burden from other specific causes is limited. This paper aimed to systematically examine th...
journal_title:Environment international
pub_type: 杂志文章,meta分析
doi:10.1016/j.envint.2020.105994
更新日期:2020-11-01 00:00:00
abstract::The aim of this review is to provide a thorough overview of the health effects from the complexed biomagnified mixture of long-range transported industrial organochlorines (OCs), polybrominated diphenyl ethers (PBDEs), perfluorinated compounds (PFCs) and mercury (Hg) on polar bear (Ursus maritimus) health. Multiple sc...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2010.03.002
更新日期:2010-07-01 00:00:00
abstract::The climatic conditions and elevation of the potential distribution area of Korean pine (Pinus koraiensis Sieb. et Zucc) in China were determined by an ecological information system GREEN that has been developed by [Yan H, Booth TH, Zuo H, editors. GREEN--a climatic mapping program for China and its use in forestry. I...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(01)00083-6
更新日期:2001-09-01 00:00:00
abstract::Surface sediment samples were collected from various locations in the Mumbai and Kochi harbours, west coast of India, to assess the presence of butyltin compounds. Tributyltin (TBT) and dibutyltin (DBT) varied from 16 to 16,816 ng/g dry wt. and from undetected to 469 ng/g dry wt., respectively, of the sediment in Koch...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2005.08.020
更新日期:2006-02-01 00:00:00
abstract::Occupational medical surveillance is highly desirable in manufacturing facilities where exposure to chemicals is significant. The insecticide fipronil is generally considered safe for humans but with increasing use, exposure to fipronil is of concern. Identification of urinary metabolites of fipronil may allow develop...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.03.012
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:"Evidence Mapping" is an emerging tool that is increasingly being used to systematically identify, review, organize, quantify, and summarize the literature. It can be used as an effective method for identifying well-studied topic areas relevant to a broad research question along with any important literature...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2018.11.070
更新日期:2019-02-01 00:00:00
abstract::This paper reports a regional contamination of the environment in central-east India that does not share geology or boundary with the Bengal Delta Plain. About 30,000 people residing in 30 villages and towns are directly exposed to arsenic and more than 200,000 people are "at risk." Complete geographical extent of thi...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(02)00022-3
更新日期:2002-09-01 00:00:00
abstract::Autochthonous bioaugmentation (ABA) strategies are primarily carried out using a single, highly efficient type of bacteria that is capable of directly degrading the target compound. However, no studies have examined the use of non-direct degraders (NDDs), which are involved in the metabolic pathway of target compounds...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105473
更新日期:2020-03-01 00:00:00
abstract:BACKGROUNDS:Evidence on the association between long-term exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) and cardiovascular disease (CVD) is scarce in developing countries. Moreover, few studies assessed the role of the PM1 (≤1.0 μm) size fraction and CVD. We investigated the associations betw...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.12.012
更新日期:2019-02-01 00:00:00
abstract::The contribution of different transportation noise sources to metabolic disorders such as obesity remains understudied. We evaluated the associations of long-term exposure to road, railway and aircraft noise with measures of obesity and its subphenotypes using cross-sectional and longitudinal designs. We assessed 3796...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.09.057
更新日期:2018-12-01 00:00:00
abstract::Spatial distribution of nonylphenol polyethoxylates (NPEOs) and nonylphenol (NP) was investigated in a field study in Lanzhou Reach of the Yellow River. NPEOs and their metabolites were found in the river, with the maximum dissolved concentrations of 6.38 nmol/L for NPEOs, 0.19 nmol/L for nonylphenol ethoxy acetic aci...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2006.06.012
更新日期:2006-09-01 00:00:00
abstract::Tamoxifen (TAM) is a first generation-SERM administered for hormone receptor-positive (HER+) breast cancer in both pre- and post-menopausal patients and may undergo metabolic activation in organisms that share similar receptors and thus face comparable mechanisms of response. The present study aimed to assess whether ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.05.014
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Human exposure to per- and polyfluoroalkyl substances (PFAS) has been primarily attributed to contaminated food and drinking water. However, additional PFAS exposure pathways have been raised by a limited number of studies reporting correlations between commercial and industrial products and PFAS levels in h...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.106308
更新日期:2021-01-01 00:00:00
abstract::For researches on toxic chemicals in settled indoor dust, selection of dust fraction is a critical influencing factor to the accuracy of human exposure risk assessment results. However, analysis of the selection of dust fraction in recent studies revealed that there is no consensus. This study classified and presented...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2012.08.010
更新日期:2012-11-15 00:00:00