Abstract:
:The aim of the study was to investigate the potential spread of gentamicin resistant (GEN(R)) Escherichia coli isolates or GEN(R) determinants from a Danish university hospital to the waste water environment. Waste water samples were collected monthly from the outlets of the hospital bed wards and the inlet of the related waste water treatment plant (WWTP) from October 2002 to August 2003. Waste water samples were also collected monthly from a residential area in the same period to be able to compare the prevalence of GEN(R)E. coli isolates from hospital related and residential waste water. The waste water isolates were compared to GEN(R)E. coli isolates obtained consecutively from September 2002 to September 2003 from patients mainly with urinary tract infections at the hospital with respect to Pulsed Field Gel Electrophoresis (PFGE) profiles. All isolates were investigated for GEN(R) mechanisms (aac(3)-II, aac(3)-IV, ant(2'')-I, armA), phenotypic resistance pattern, and virulence genes (hlyA, chuA, sfaS, fogG, malX, traT, iutA, fyuA, iroN, cnf1) to investigate if the hospital and waste water could be reservoirs of antimicrobial resistance and virulence. The ability for GEN(R) determinants to transfer horizontally was investigated by mating experiments. A total of 38, 15, 21, and two GEN(R)E. coli were isolated from patients, the hospital outlets, the inlet of the WWTP, and the residential area, respectively. GEN(R)E. coli were more prevalent in waste water from the hospital and the WWTP than in waste water from the residential area. PFGE profiling revealed no spread of specific patient isolates to the waste water. The aac(3)-II gene was detected both in patient and waste water isolates. Furthermore horizontal transfer of the aac(3)-II gene of patient origin to a recipient was shown in vitro, indicating a potential spread of the gene from patient isolates to waste water isolates. Regardless of origin, most isolates exhibited multi-resistance and contained several virulence genes. In conclusion, our study showed a possible spread of aac(3)-II from the hospital to the waste water. Most of the GEN(R)E. coli isolates from both patients and waste water had a multi-resistant phenotype and contained virulence genes and should therefore be considered reservoirs of antimicrobial resistance and virulence genes.
journal_name
Environ Intjournal_title
Environment internationalauthors
Jakobsen L,Sandvang D,Hansen LH,Bagger-Skjøt L,Westh H,Jørgensen C,Hansen DS,Pedersen BM,Monnet DL,Frimodt-Møller N,Sørensen SJ,Hammerum AMdoi
10.1016/j.envint.2007.07.011subject
Has Abstractpub_date
2008-01-01 00:00:00pages
108-15issue
1eissn
0160-4120issn
1873-6750pii
S0160-4120(07)00142-0journal_volume
34pub_type
杂志文章abstract::Persistent organic pollutants (POPs) accumulate in the food web of the Great Lakes ecosystem, causing concern that these chemicals play a role in the decline of avian species such as colonial-nesting waterbirds. In this study, samples from four life stages of the common tern (Sterna hirundo), a threatened species in N...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.106065
更新日期:2020-11-01 00:00:00
abstract::Di(2-ethylhexyl) phthalate (DEHP) is one of the common phthalate plasticizers used primarily in soft polyvinyl chloride, which is a plastic polymer that makes up the total weight of goods from 1% up to 40% in many consumer products. The aims of this study were to examine the urinary DEHP metabolites in South Korean ch...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.01.007
更新日期:2013-04-01 00:00:00
abstract::This study investigated perfluoroalkyl acids (PFAAs) in edible parts of vegetables, soils, and irrigation water in greenhouse and open filed, for the first time, in Shouguang city, the largest vegetable production base in China, which is located nearby a fluorochemical industrial park (FIP). The bioaccumulation factor...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105347
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Bio-accumulation of persistent organic pollutants (POPs) in the environment and in the food chain can lead to high pollutant concentrations in human fat-containing tissues and breast milk. OBJECTIVES:We aimed to identify the maternal characteristics that determined POP concentrations in breast milk of primi...
journal_title:Environment international
pub_type: 杂志文章,多中心研究
doi:10.1016/j.envint.2019.104979
更新日期:2019-10-01 00:00:00
abstract::In the context of assessing potential risks of engineered nanoparticles (ENPs), life cycle thinking can represent a holistic view on the impacts of ENPs through the entire value chain of nano-enhanced products from production, through use, and finally to disposal. Exposure to ENPs in consumer or environmental settings...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2015.01.013
更新日期:2015-04-01 00:00:00
abstract::Autochthonous bioaugmentation (ABA) strategies are primarily carried out using a single, highly efficient type of bacteria that is capable of directly degrading the target compound. However, no studies have examined the use of non-direct degraders (NDDs), which are involved in the metabolic pathway of target compounds...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105473
更新日期:2020-03-01 00:00:00
abstract::The acute toxicity of citrate capped silver nanoparticles (AgNP) and silver nitrate was evaluated on the marine macroalga Ulva rigida C. Agardh (1823). Silver bioaccumulation, ultrastructural chloroplast damages verified by TEM microscopy, inhibition of primary production, neutral lipid production and oxidative stress...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.104942
更新日期:2019-10-01 00:00:00
abstract::The EU directives on air quality force member states to inform the public on the status of the ambient air quality. The Internet is commonly used for this purpose and often air quality is being presented as an index ranging from good to bad. A review of existing websites and air quality indices shows that the way air ...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2007.12.011
更新日期:2008-07-01 00:00:00
abstract::Environmental risk assessment and decision-making strategies over the last several decades have become increasingly more sophisticated, information-intensive, and complex, including such approaches as expert judgment, cost-benefit analysis, and toxicological risk assessment. One tool that has been used to support envi...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2006.06.013
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:We evaluated methods for the analysis of multi-level survival data using a pooled dataset of 14 cohorts participating in the ELAPSE project investigating associations between residential exposure to low levels of air pollution (PM2.5 and NO2) and health (natural-cause mortality and cerebrovascular, coronary ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.106371
更新日期:2021-02-01 00:00:00
abstract::This study examined the exposure level of aromatic volatile organic compounds (VOCs) in public transportation modes in Guangzhou, China. A total of 40 VOC samples were conducted in four popular public commuting modes (subway, taxis, non-air-conditioned buses and air-conditioned buses) while traversing in urban areas o...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/S0160-4120(02)00189-7
更新日期:2003-07-01 00:00:00
abstract::Seaweed has a long-associated history of use as a supplemented livestock feed, providing nutrients and vitamins essential to maintaining animal health. Some species of seaweed, particularly the fucoids, are well-known accumulators of the metalloid arsenic (As). Arsenic toxicity to humans is well established even at lo...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.05.032
更新日期:2018-09-01 00:00:00
abstract::Thermal treatment of plastics flame retarded with brominated compounds often lead to the formation of PBDD/F, especially if polybrominated diphenyl ethers are used. By the presence of antimony(III) oxide, water and some other metals, the amounts of PBDD/F increase. Even during the production and recycling processes of...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/S0160-4120(03)00117-X
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Phenol exposure during pregnancy has been associated with preterm birth, but the potential effect of preconception exposure in either parent is unknown. There is a growing body of evidence to suggest that the preconception period is a critical window of vulnerability for adverse pregnancy outcomes. OBJECTIV...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105523
更新日期:2020-04-01 00:00:00
abstract::Japanese encephalitis (JE) is the most common cause of viral encephalitis and an important public health concern in the Asia-Pacific region, particularly in China where 50% of global cases are notified. To explore the association between environmental factors and human JE cases and identify the high risk areas for JE ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.07.004
更新日期:2014-12-01 00:00:00
abstract::In 1998 and 1999, the concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) were determined in soil and herbage samples collected in the vicinity of an old municipal solid waste incinerator (MSWI) (S. Adrià del Besòs, Barcelona, Spain). Just after the 1999 collection, an adaptation to the EU ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/s0160-4120(01)00129-5
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:In competing risks settings, the cause-specific cumulative incidence function is of great interest since it quantifies cumulative risk in the presence of other causes. To date, however, long-term cancer- and noncancer-specific mortality in Yusho patients exposed to polychlorinated biphenyls (PCBs) and dioxin...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.106320
更新日期:2021-02-01 00:00:00
abstract::Internationally publicized impacts upon human health associated with potentially harmful element (PHE) exposure have been reported amongst internally displaced populations (IDPs) in Mitrovica, Kosovo, following the Kosovan War. Particular concern has surrounded the exposure to Pb indicated by the presence of highly el...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.07.014
更新日期:2013-10-01 00:00:00
abstract::Pooled yellow eel (Anguilla anguilla L.) samples, consisting of 3-10 eels, from 50 locations collected in the period 2000-2006 were used to assess the pollution with PBDEs and HBCDs in Flemish waters (Belgium). Results from this monitoring network are presented and the spatial aspect throughout Flanders is included, l...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2010.03.001
更新日期:2010-07-01 00:00:00
abstract::The COVID-19 pandemic placed public health measures against infectious diseases at the core of global health challenges, especially in cities where more than half of the global population lives. SARS-CoV-2 is an exposure agent recently added to the network of exposures that comprise the human exposome, i.e. the totali...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2020.106246
更新日期:2021-01-01 00:00:00
abstract::The distribution of dissolved rare earth elements (REE) in the Rhine River, Germany, shows the anthropogenic gadolinium (Gd) microcontamination that is commonly observed in rivers in densely populated countries with a highly evolved health care system. However, the Rhine River also carries anomalously high concentrati...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2011.02.018
更新日期:2011-07-01 00:00:00
abstract::Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in populations worldwide and may hinder kidney function. The objective of the study was to determine longitudinal associations of plasma PFAS concentrations with estimated glomerular filtration rate (eGFR) and evaluate whether a lifestyle interventio...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.106375
更新日期:2021-01-19 00:00:00
abstract::Nano zero-valent iron (nZVI) and its composite materials have been extensively studied in the field of environmental remediation. However, the oxidation and agglomeration of nZVI limits the large-scale application of nZVI in environmental remediation. This study developed a two-step method to prepare stable carbon-coa...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105639
更新日期:2020-05-01 00:00:00
abstract::Neonicotinoid insecticides are ubiquitous in food and the environment due to their wide use. Growing evidence suggests the adverse effects of neonicotinoids in many species, including mammals. Some studies have reported the urinary concentrations of neonicotinoids in human biological monitoring, but the potential risk...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105399
更新日期:2020-02-01 00:00:00
abstract::Since 2000 there has been an on-going industrial transition to replace long-chain perfluoroalkyl carboxylic acids(PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their precursors. To date, information on these replacements including their chemical identities, however, has not been published or made easily accessibl...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2013.08.021
更新日期:2013-10-01 00:00:00
abstract::The structural analogs, 2,4-dibromophenol (2,4-DBP) and 2,4-dibromoanisole (2,4-DBA), have both natural and artificial sources and are frequently detected in environmental matrices. Their environmental fates, especially volatilization, including both direct volatilization from cultivation solution and phytovolatilizat...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105888
更新日期:2020-09-01 00:00:00
abstract::We aimed to estimate the levels and time trends of perfluorinated alkyl acids (PFAAs) in serum of 1533 Danish pregnant nulliparous women between 2008 and 2013. The selection criterion of only including nulliparous women was chosen to avoid confounding from parity. The serum samples were analyzed for sixteen PFAAs usin...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.02.010
更新日期:2016-05-01 00:00:00
abstract::Both dietary and non-dietary pathways contribute to metal exposure in residents living near mining-impacted areas. In this study, bioavailability-based metal intake estimation coupled with stable Pb isotope ratio fingerprinting technique were used to discern dietary (i.e., rice consumption) and non-dietary (i.e., hous...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.08.023
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Polycyclic aromatic hydrocarbons (PAH) are carcinogenic, neurotoxic environmental pollutants generated during incomplete combustion of fossil fuel and other organic material. PAH exposure has been associated with adverse fetal development and epigenetic alterations in cord blood. Several molecular epidemiolo...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.12.009
更新日期:2017-02-01 00:00:00
abstract::The accumulation rates, the geochronology of metals and PAH contamination, and the Microtox toxicity are studied in five sediment cores (50 cm length) covering different areas of the Santander Bay, Northern Spain. Chronology given by (210)Pb and (137)Cs reveals significant differences in accumulation rates between sit...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2006.10.005
更新日期:2007-05-01 00:00:00