Primary nasopharyngeal carcinoma: diagnostic accuracy of MR imaging versus that of endoscopy and endoscopic biopsy.


PURPOSE:To compare the accuracy of magnetic resonance (MR) imaging with that of the current clinical standard of endoscopy and endoscopic biopsy, to determine whether MR imaging depicts subclinical cancers missed at endoscopy and endoscopic biopsy, and to determine whether MR imaging can identify patients without nasopharyngeal carcinoma (NPC) who do not need to undergo invasive sampling biopsy. MATERIALS AND METHODS:The study protocol was approved by the institutional review board; written informed consent was obtained from all patients. Patients suspected of having NPC underwent MR imaging, endoscopy, and endoscopic biopsy. Endoscopic biopsy targeted the suspected tumor or sampled the endoscopically normal nasopharynx. The final diagnosis was based on results of the endoscopic biopsy or on results of a repeat biopsy directed at the lesion detected at MR imaging. The sensitivity and specificity of the three investigations were compared by using the Fisher exact test. RESULTS:NPC was present in 77 (31%) of 246 patients and absent in 169 (69%) patients. The combined sensitivity, specificity, and accuracy, respectively, were 100%, 93%, and 95% for MR imaging, 90%, 93%, and 92% for endoscopy, and 95%, 100%, and 98% for endoscopic biopsy. Benign disease was mistaken for NPC in 12 (7%) of 169 patients at MR imaging and in 11 (6%) patients at endoscopy. The sensitivity of MR imaging was significantly higher than that of endoscopy (P = .006) and was similar to that of endoscopic biopsy (P = .120). The specificity of MR imaging was similar to that of endoscopy (P = .120) and was significantly lower than that of endoscopic biopsy (P < .001). CONCLUSION:MR imaging is an accurate test for the diagnosis of NPC. MR imaging depicts subclinical cancers missed at endoscopy and endoscopic biopsy and helps identify the majority of patients who do not have NPC and who therefore do not need to undergo invasive sampling biopsies.






King AD,Vlantis AC,Bhatia KS,Zee BC,Woo JK,Tse GM,Chan AT,Ahuja AT




Has Abstract


2011-02-01 00:00:00














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    abstract:PURPOSE:To evaluate the usefulness of Doppler ultrasonography (US) in the diagnosis of hyperfiltration in patients with insulin-dependent diabetes mellitus (IDDM). MATERIALS AND METHODS:Eighty-one consecutive patients with IDDM were studied. All patients were normotensive and had normal creatinine and blood urea nitro...


    pub_type: 临床试验,杂志文章


    authors: Marzano MA,Pompili M,Rapaccini GL,Covino M,Cotroneo P,Manto A,Todaro L,Ghirlanda G,Gasbarrini G

    更新日期:1998-12-01 00:00:00

  • Effect of Radiation Dose Reduction and Reconstruction Algorithm on Image Noise, Contrast, Resolution, and Detectability of Subtle Hypoattenuating Liver Lesions at Multidetector CT: Filtered Back Projection versus a Commercial Model-based Iterative Reconst

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    pub_type: 杂志文章


    authors: Solomon J,Marin D,Roy Choudhury K,Patel B,Samei E

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    pub_type: 杂志文章


    authors: Robertson CL

    更新日期:1993-04-01 00:00:00

  • Acute cholecystitis at T2-weighted and manganese-enhanced T1-weighted MR cholangiography: preliminary study.

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    pub_type: 杂志文章


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  • Regional Mapping of Aortic Wall Stress by Using Deformable, Motion-coherent Modeling based on Electrocardiography-gated Multidetector CT Angiography: Feasibility Study.

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    pub_type: 杂志文章


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  • Primary adenoid cystic carcinoma (cylindroma) of the trachea.

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    pub_type: 杂志文章


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  • Assessing radiologist performance using combined digital mammography and breast tomosynthesis compared with digital mammography alone: results of a multicenter, multireader trial.

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    pub_type: 杂志文章


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  • Dedifferentiated chondrosarcoma: radiographic features.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Higgins CB,Feld GK

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Rifkin MD,Friedland GW,Shortliffe L

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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