Abstract:
:Acute graft-versus-host disease (aGVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (alloHCT) and is a major cause of morbidity and mortality. Systemic steroid therapy is the first-line treatment for aGVHD, although about half of patients will become refractory to treatment. As the number of patients undergoing alloHCT increases, developing safe and effective treatments for aGVHD will become increasingly important, especially for those whose disease becomes refractory to systemic steroid therapy. This paper reviews current treatment options for patients with steroid-refractory aGVHD and discusses data from recently published clinical studies to outline emerging therapeutic strategies.
journal_name
Leukemiajournal_title
Leukemiaauthors
Malard F,Huang XJ,Sim JPYdoi
10.1038/s41375-020-0804-2subject
Has Abstractpub_date
2020-05-01 00:00:00pages
1229-1240issue
5eissn
0887-6924issn
1476-5551pii
10.1038/s41375-020-0804-2journal_volume
34pub_type
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