The secretion of insulin-like growth factors I and II by explant cultures of fibroids and myometrium from women treated with a gonadotropin-releasing hormone agonist.

Abstract:

:The gonadotropin-releasing hormone agonist (GnRH-a) leuprolide acetate depot was used as a biologic probe to investigate the possible roles of insulin-like growth factors (IGFs) I and II in fibroid growth. The secretion of IGF-I and IGF-II by explant cultures of fibroids and myometria from women treated with a GnRH-a was compared with that of tissue obtained from placebo-treated controls. Patients were randomized to receive either leuprolide 3.75 mg every 28 days (N = 9) or placebo injections (N = 8) before myomectomy. Fresh tissue was diced into 2-mm3 explants and cultures were established in serum-free media. The media were assayed for IGF-I, IGF-II, and total protein. Patients treated with GnRH-a demonstrated a 34% reduction in uterine volume, whereas placebo-treated patients exhibited no change. The secretion of IGF-I and IGF-II by fibroid explants obtained from women treated with the GnRH-a was significantly less than that in tissue obtained from placebo-treated controls (P less than .01 and P less than or equal to .05, respectively). Similarly, the secretion of IGF-I and IGF-II by myometrial explants was significantly less in tissue obtained from women treated with GnRH-a (P less than .0001 for both IGF-I and IGF-II). Protein secretion by fibroid tissue obtained from women treated with GnRH-a was not significantly different when compared with tissue from placebo-treated controls. In conclusion, fibroids and myometria from women pretreated with the GnRH-a secreted significantly less IGF-I and IGF-II than did tissue obtained from placebo-treated controls.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Obstet Gynecol

authors

Rein MS,Friedman AJ,Pandian MR,Heffner LJ

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

388-94

issue

3 Pt 1

eissn

0029-7844

issn

1873-233X

journal_volume

76

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:OBJECTIVE:To review facility-based maternal deaths at a tertiary-level center in Johannesburg, South Africa, during a 5-year period (2003 to 2007) and to investigate the proportion of deaths attributable to human immunodeficiency virus (HIV), the etiology of deaths, and the effects of antiretroviral treatment introduce...

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    authors: Black V,Brooke S,Chersich MF

    更新日期:2009-08-01 00:00:00

  • Special requirements of electronic medical record systems in obstetrics and gynecology.

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    journal_title:Obstetrics and gynecology

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    authors: McCoy MJ,Diamond AM,Strunk AL,American Congress of Obstetricians and Gynecologists' Committee on Ambulatory Practice Operations.

    更新日期:2010-07-01 00:00:00

  • Acardiac twin pregnancy with neonatal resolution of donor twin cardiomyopathy.

    abstract:BACKGROUND:Twin reverse arterial perfusion, as with acardiac fetuses, is a rare complication of multifetal pregnancy. Prognosis of the donor twin is guarded because of the high risk of cardiac failure, polyhydramnios, and preterm delivery. CASE:A 40-year-old woman, gravida 4, para 3, was diagnosed at 19 weeks' gestati...

    journal_title:Obstetrics and gynecology

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    authors: Chandra S,Crane JM,Young DC,Shah S

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  • Association of the Affordable Care Act With Ovarian Cancer Care.

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  • Comparison of ultrasonographic and digital cervical evaluation.

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    journal_title:Obstetrics and gynecology

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    authors: O'Leary JA,Ferrell RE

    更新日期:1986-11-01 00:00:00

  • Association of abnormal ovarian reserve parameters with a higher incidence of aneuploid blastocysts.

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    authors: Katz-Jaffe MG,Surrey ES,Minjarez DA,Gustofson RL,Stevens JM,Schoolcraft WB

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    authors: Smith AJB,Applebaum J,Tanner EJ,Capone GT

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    journal_title:Obstetrics and gynecology

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    更新日期:1988-12-01 00:00:00

  • Committee Opinion No 708: Improving Awareness of and Screening for Health Risks Among Sex Workers.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章,实务指引

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    journal_title:Obstetrics and gynecology

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    authors: Seifer DB,Gutmann JN,Grant WD,Kamps CA,DeCherney AH

    更新日期:1993-03-01 00:00:00

  • Increased risk of preterm birth in women with cervical conization.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

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  • Modified Open Laparoscopy Using a 5-mm Laparoscope.

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    journal_title:Obstetrics and gynecology

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    更新日期:2016-03-01 00:00:00

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    更新日期:1975-11-01 00:00:00

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    更新日期:1983-12-01 00:00:00

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    journal_title:Obstetrics and gynecology

    pub_type: 临床试验,杂志文章

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  • Pelvic floor evaluation with dynamic fluoroscopy.

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    journal_title:Obstetrics and gynecology

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    doi:

    authors: Brubaker L,Retzky S,Smith C,Saclarides T

    更新日期:1993-11-01 00:00:00

  • ACOG Committee Opinion No. 766 Summary: Approaches to Limit Intervention During Labor and Birth.

    abstract::Obstetrician-gynecologists, in collaboration with midwives, nurses, patients, and those who support them in labor, can help women meet their goals for labor and birth by using techniques that require minimal interventions and have high rates of patient satisfaction. Many common obstetric practices are of limited or un...

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Harger JH,Archer DF,Marchese SG,Muracca-Clemens M,Garver KL

    更新日期:1983-11-01 00:00:00

  • Thermoregulation during aerobic exercise in pregnancy.

    abstract::To characterize maternal thermal balance during pregnancy, the authors recorded the thermal response to moderate weight bearing exercise stress in four aerobically conditioned pregnant women. Studies were performed in a climate-controlled environment in each trimester of pregnancy and postpartum after modifying the ex...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Jones RL,Botti JJ,Anderson WM,Bennett NL

    更新日期:1985-03-01 00:00:00

  • Occurrence and predictors of cesarean delivery for the second twin after vaginal delivery of the first twin.

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    journal_title:Obstetrics and gynecology

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    更新日期:2017-03-01 00:00:00

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    pub_type: 杂志文章

    doi:

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    更新日期:1972-08-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Naguib SM,Lundin FE Jr,Davis HJ

    更新日期:1966-10-01 00:00:00

  • Typhoid fever in pregnancy.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:

    authors: Seoud M,Saade G,Uwaydah M,Azoury R

    更新日期:1988-05-01 00:00:00

  • Can amnio-polymerase chain reaction alone replace conventional cytogenetic study for women with positive biochemical screening for fetal Down syndrome?

    abstract::To determine whether amnio-polymerase chain reaction (amnio-PCR) can replace conventional cytogenetic study for confirming the karyotype of fetuses in women with positive biochemical screening for fetal Down syndrome. To check the accuracy of this technique in our laboratory, we first compared the amnio-PCR results wi...

    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0029-7844(03)00222-9

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    更新日期:2003-05-01 00:00:00

  • Primary vulvar nocardiosis.

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    journal_title:Obstetrics and gynecology

    pub_type: 杂志文章

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    doi:

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