Abstract:
:Two patients with insular and striatal postnatal scar had epileptic spasms (ES) that were asymmetrical and the only seizure type, whereas none of the usual ictal symptoms of insular seizures occurred. Ictal electroencephalography (EEG) showed the high-amplitude slow-wave characteristic of ES. Vigabatrin remained efficient for over 4 years for one patient and right into the third decade for the other one. Such ES are distinct from infantile and late onset spasms. Furthermore, these observations suggest that in ES insular epilepsy triggers paroxysmal activation of the striatum, and that vigabatrin inhibits the striatal startle motor program, thus interrupting the corticostriatal loop.
journal_name
Neuropediatricsjournal_title
Neuropediatricsauthors
Kharytonov V,Dulac Odoi
10.1055/s-0040-1702226subject
Has Abstractpub_date
2020-08-01 00:00:00pages
295-297issue
4eissn
0174-304Xissn
1439-1899journal_volume
51pub_type
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