Nonparametric estimation of broad sense agreement between ordinal and censored continuous outcomes.

abstract：:Shared random effects models have been increasingly common in the joint analyses of repeated measures (e.g. CD4 counts, hemoglobin levels) and a correlated failure time such as death. In this paper we study several shared random effects models in the multi-level repeated measures data setting with dependent failure ti...

journal_title：Statistics in medicine

authors： Liu L,Ma JZ,O'Quigley J

更新日期：2008-11-29 00:00:00

abstract：:Assessment of equivalence or non-inferiority in accuracy between two diagnostic procedures often involves comparisons of paired areas under the receiver operating characteristic (ROC) curves. With some pre-specified clinically meaningful limits, the current approach to evaluating equivalence is to perform the two one-...

journal_title：Statistics in medicine

authors： Liu JP,Ma MC,Wu CY,Tai JY

更新日期：2006-04-15 00:00:00

abstract：:We examine Goodman and Kruskal's lambda using Efron's approach to regression and analysis of variance (ANOVA) for zero-one outcome data. For a binary response cross-classified by a single nominal predictor, we present a computationally simple ANOVA table in which lambda is analogous to Pearson's R-square. We character...

journal_title：Statistics in medicine

authors： Makuch RW,Rosenberg PS,Scott G

更新日期：1989-05-01 00:00:00

abstract：:Studies involving longitudinal binary responses are widely applied in the health and biomedical sciences research and frequently analyzed by generalized estimating equations (GEE) method. This article proposes an alternative goodness-of-fit test based on the nonparametric smoothing approach for assessing the adequacy ...

journal_title：Statistics in medicine

authors： Lin KC,Chen YJ,Shyr Y

更新日期：2008-09-30 00:00:00

abstract：:The Jimma Infant Survival Differential Longitudinal Study is an Ethiopian study, set up to establish risk factors affecting infant survival and to investigate socio-economic, maternal and infant-rearing factors that contribute most to the child's early survival. Here, a subgroup of about 1500 children born in Jimma to...

journal_title：Statistics in medicine

authors： Lesaffre E,Asefa M,Verbeke G

更新日期：1999-04-15 00:00:00

abstract：:Measures that quantify the impact of heterogeneity in univariate meta-analysis, including the very popular I(2) statistic, are now well established. Multivariate meta-analysis, where studies provide multiple outcomes that are pooled in a single analysis, is also becoming more commonly used. The question of how to quan...

journal_title：Statistics in medicine

authors： Jackson D,White IR,Riley RD

更新日期：2012-12-20 00:00:00

abstract：:We analyze data obtained from a study designed to evaluate training effects on the performance of certain motor activities of Parkinson's disease patients. Maximum likelihood methods were used to fit beta-binomial/Poisson regression models tailored to evaluate the effects of training on the numbers of attempted and su...

journal_title：Statistics in medicine

authors： Lora MI,Singer JM

更新日期：2008-07-30 00:00:00

abstract：:The Box-Cox power exponential (BCPE) distribution, developed in this paper, provides a model for a dependent variable Y exhibiting both skewness and kurtosis (leptokurtosis or platykurtosis). The distribution is defined by a power transformation Y(nu) having a shifted and scaled (truncated) standard power exponential ...

journal_title：Statistics in medicine

authors： Rigby RA,Stasinopoulos DM

更新日期：2004-10-15 00:00:00

abstract：:We propose to use a very simple model to test whether a cancer cluster is due to chance alone. We focus on the acute childhood leukaemia cluster in Columbus, Ohio. In 1975, 12 leukaemia cases were observed in Columbus while the expected number is 6 cases per year. According to our simple model, the probability of such...

journal_title：Statistics in medicine

authors： Schinazi RB

更新日期：2000-08-30 00:00:00

abstract：:Patient reported outcome and observer evaluative studies in clinical trials and post-hoc analyses often use instruments that measure responses on ordinal-rating or Likert scales. We propose a flexible distributional approach by modeling the change scores from the baseline to the end of the study using independent beta...

journal_title：Statistics in medicine

authors： Zou KH,Carlsson MO,Quinn SA

更新日期：2010-10-30 00:00:00

abstract：:Hot-deck imputation is an intuitively simple and popular method of accommodating incomplete data. Users of the method will often use the usual multiple imputation variance estimator which is not appropriate in this case. However, no variance expression has yet been derived for this easily implemented method applied to...

journal_title：Statistics in medicine

authors： Reilly M,Pepe M

更新日期：1997-01-15 00:00:00

abstract：:We examine different methods to pool binary outcomes used both in parallel and cross-over trials. Odds ratio (OR) estimators obtained from joint conditional probabilities in cross-over trials, such as the Mantel-Haenszel and Peto methods, are compared to an OR estimator using marginal results of cross-over trials. Whe...

journal_title：Statistics in medicine

authors： Curtin F,Elbourne D,Altman DG

更新日期：2002-08-15 00:00:00

abstract：:We propose a two-step procedure to personalize drug dosage over time under the framework of a log-linear mixed-effect model. We model patients' heterogeneity using subject-specific random effects, which are treated as the realizations of an unspecified stochastic process. We extend the conditional quadratic inference ...

journal_title：Statistics in medicine

authors： Zhu X,Qu A

更新日期：2016-10-30 00:00:00

abstract：:Identification of treatment selection biomarkers has become very important in cancer drug development. Adaptive enrichment designs have been developed for situations where a unique treatment selection biomarker is not apparent based on the mechanism of action of the drug. With such designs, the eligibility rules may b...

journal_title：Statistics in medicine

authors： Simon R,Simon N

更新日期：2017-11-20 00:00:00

abstract：:A new goodness-of-fit test for the logistic regression model is proposed. It exploits the property of this model that when it is correct, i.e. not misspecified, the parameter estimates are (asymptotically) invariant under reweighting the observations by weights wi that are a function of the binary (0/1) outcomes yi. M...

journal_title：Statistics in medicine

authors： Nagelkerke N,Smits J,le Cessie S,van Houwelingen H

更新日期：2005-01-15 00:00:00

abstract：:Optimal prevention and treatment strategies for a disease of multiple causes, such as pneumonia, must be informed by the population distribution of causes among cases, or cause-specific case fractions (CSCFs). CSCFs may further depend on additional explanatory variables. Existing methodological literature in disease e...

journal_title：Statistics in medicine

authors： Wu Z,Chen I

更新日期：2021-02-20 00:00:00

abstract：:Arming the immune system against cancer has emerged as a powerful tool in oncology during recent years. Instead of poisoning a tumor or destroying it with radiation, therapeutic cancer vaccine, a type of cancer immunotherapy, unleashes the immune system to combat cancer. This indirect mechanism-of-action of vaccines p...

journal_title：Statistics in medicine

authors： Xu Z,Zhen B,Park Y,Zhu B

更新日期：2017-02-20 00:00:00

abstract：:Several large-sample confidence intervals for the ratio of independent binomial proportions are compared in terms of exact coverage probability and width. A non-iterative approximate Bayesian interval is derived and its frequency properties are superior to all of the non-iterative confidence intervals considered. The ...

journal_title：Statistics in medicine

authors： Price RM,Bonett DG

更新日期：2008-11-20 00:00:00

abstract：:In many epidemiological studies it is common to resort to regression models relating incidence of a disease and its risk factors. The main goal of this paper is to consider inference on such models with error-prone observations and variances of the measurement errors changing across observations. We suppose that the o...

journal_title：Statistics in medicine

authors： de Castro M,Galea M,Bolfarine H

更新日期：2008-11-10 00:00:00

abstract：:The mutation and natural selection phenomenon can and often does cause the failure of antimicrobial, herbicidal, pesticide and cancer treatments selection pressures. This phenomenon operates in a mathematically predictable behavior, which when understood leads to approaches to reduce and prevent the failure of the use...

journal_title：Statistics in medicine

authors： Kleinman A

更新日期：2014-12-20 00:00:00

abstract：:We applied a two-stage random effects model to pulmonary function data from 31 sarcoidosis patients to illustrate its usefulness in analysing unbalanced longitudinal data. For the first stage, repeated measurements of percentage of predicted forced vital capacity (FVC%) from an individual were modelled as a function o...

journal_title：Statistics in medicine

authors： Vacek PM,Mickey RM,Bell DY

更新日期：1989-02-01 00:00:00

abstract：:We propose the use of Gaussian mixed models to analyse statistically 24 hour ambulatory blood pressure data from clinical trials. We develop specific models and apply them to data from a clinical study that compares two angiotensin-converting enzyme inhibitors. We investigate and discuss computing issues related to th...

journal_title：Statistics in medicine

authors： Selwyn MR,Difranco DM

更新日期：1993-09-30 00:00:00

abstract：:We describe how trends in the vaccination coverage at 19 months of age vary by race/ethnicity; explore the extent to which data required to evaluate a child's up-to-date vaccination status is missing as a result of the scattering of vaccination records among many vaccination providers; evaluate how the prevalence of t...

journal_title：Statistics in medicine

authors： Smith PJ,Stevenson J

更新日期：2008-09-10 00:00:00

abstract：:Missing data arise in crossover trials, as they do in any form of clinical trial. Several papers have addressed the problems that missing data create, although almost all of these assume that the probability that a planned observation is missing does not depend on the value that would have been observed; that is, the ...

journal_title：Statistics in medicine

authors： Ho WK,Matthews JN,Henderson R,Farewell D,Rodgers LR

更新日期：2012-07-20 00:00:00

abstract：:We propose a probability distribution for an equivalence class of classification trees (that is, those that ignore the value of the cutpoints but retain tree structure). This distribution is parameterized by a central tree structure representing the true model, and a precision or concentration coefficient representing...

journal_title：Statistics in medicine

authors： Shannon WD,Banks D

更新日期：1999-03-30 00:00:00

abstract：:In the field of cluster detection, a weighted normal model-based scan statistic was recently developed to analyze regional continuous data and to evaluate the clustering pattern of pre-defined cells (such as state, county, tract, school, hospital) that include many individuals. The continuous measures of interest are,...

journal_title：Statistics in medicine

authors： Huang L,Tiwari RC,Pickle LW,Zou Z

更新日期：2010-10-15 00:00:00

abstract：:The Cochran-Armitage trend test has been used in case-control studies for testing genetic association. As the variance of the test statistic is a function of unknown parameters, e.g. disease prevalence and allele frequency, it must be estimated. The usual estimator combining data for cases and controls assumes they fo...

journal_title：Statistics in medicine

authors： Zheng G,Gastwirth JL

更新日期：2006-09-30 00:00:00

abstract：:Many gene expression data are based on two experiments where the gene expressions of the targeted genes under both experiments are correlated. We consider problems in which objectives are to find genes that are simultaneously upregulated/downregulated under both experiments. A Bayesian methodology is proposed based on...

journal_title：Statistics in medicine

authors： Bansal NK,Jiang H,Pradeep P

更新日期：2015-11-10 00:00:00

abstract：:Using both simulated and real datasets, we compared two approaches for estimating absolute risk from nested case-control (NCC) data and demonstrated the feasibility of using the NCC design for estimating absolute risk. In contrast to previously published results, we successfully demonstrated not only that data from a ...

journal_title：Statistics in medicine

authors： Salim A,Delcoigne B,Villaflores K,Koh WP,Yuan JM,van Dam RM,Reilly M

更新日期：2017-02-10 00:00:00

abstract：:Comparative effectiveness research represents the kind of research that arguably more directly affects clinical practice and policy. It includes observational studies, clinical trials, and systematic syntheses of existing literature. In this commentary, I argue for the ongoing and critical role of randomization in com...

journal_title：Statistics in medicine

authors： Lauer MS

更新日期：2012-11-10 00:00:00