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Liquid chromatographic separation and stereoselective detection of L- and D-amino acids with catalytic reaction detection using immobilized enzymes.

Abstract：

:A post-column LC detection system is described for the stereoselective detection of L- and D-amino acids. The effluent of the LC column passes an immobilized enzyme reactor (IMER) containing either L- or D-amino acid oxidase. The hydrogen peroxide formed in this reactor by the oxidation of the amino acids is then transported to a second IMER containing horse-radish peroxidase. With the addition of 4-aminophenazone and dichlorophenosulphonyl chloride to the carrier, the hydrogen peroxide is reacted to form a red-coloured complex which is detected in a flow-through photometric cell at 514 nm. Applications to the analysis of amino acids in bovine and human sera are described.

journal_name

J Pharm Biomed Anal

journal_title

Journal of pharmaceutical and biomedical analysis

authors

Domínguez E,Marko-Varga G,Carlsson M,Gorton L

doi

10.1016/0731-7085(90)80127-b

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

825-30

issue

8-12

eissn

0731-7085

issn

1873-264X

pii

0731-7085(90)80127-B

journal_volume

8

pub_type

杂志文章

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