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Atherosclerosis drug development in jeopardy: the need for predictive biomarkers of treatment response.

Abstract：

:The limited predictability of phase II biomarkers for atherosclerosis outcomes in phase III studies stands in contrast to the number and varied types of biomarkers--soluble, imaging, and functional--that have been used in a diverse array of trials. Although collectively abundant, these biomarker data exist in a fragmented state. Most biomarkers are studied one at a time, only measure a specific aspect of atherosclerosis, are not integrated in a substantive way, and compete with one another for validation; in the end, progress is slow. The proposed solution from the Atherosclerosis Working Group, a committee of experts from academia, the pharmaceutical industry, government, and the nonprofit sector and managed by the Foundation for the National Institutes of Health Biomarkers Consortium, is to integrate these different measures into an in silico model of atherosclerosis. Through integration of diverse biomarker measurements and outcomes in silico, we may be able to improve trial design as well as the predictive power of short-term markers for longer-term outcomes.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Fryburg DA,Vassileva MT

doi

10.1126/scitranslmed.3002029

subject

Has Abstract

pub_date

2011-03-02 00:00:00

pages

72cm6

issue

72

eissn

1946-6234

issn

1946-6242

pii

3/72/72cm6

journal_volume

3

pub_type

杂志文章

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