当前位置： SCI文献检索 > Science Translational Medicine期刊下所有文献 > Changing models of biomedical research.

Changing models of biomedical research.

Abstract：

:Thanks to the revolutions in information technology, human "-omics" research, and intricate medical device development, academic health centers (AHCs) now have an unparalleled potential to become translational engines that both generate basic science advances and then translate them into human studies and, ultimately, into improved health care. However, AHC infrastructures have traditionally been optimized to foster basic research. Now modifications must be made to meet these expanded roles of AHCs, from providing fundamental biomedical insights to first-in-human interventions and, if warranted, to larger randomized clinical trials. Eventually, AHCs must integrate these improved treatments into patient care. Challenges to this process have been defined by the Institute of Medicine. Building the appropriate infrastructures for human investigation and stabilizing the careers of young physicians essential to these translational events have become critical needs that will require systemic investments if AHCs are to respond to these biological revolutions and fulfill their promise.

journal_name

Sci Transl Med

journal_title

Science translational medicine

authors

Crowley WF Jr,Gusella JF

doi

10.1126/scitranslmed.3000124

subject

Has Abstract

pub_date

2009-10-07 00:00:00

pages

1cm1

issue

1

eissn

1946-6234

issn

1946-6242

pii

1/1/1cm1

journal_volume

1

pub_type

杂志文章

相关文献

Science Translational Medicine文献大全
  • Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.

    abstract：:Venetoclax is a specific B cell lymphoma 2 (BCL-2) inhibitor with promising activity against acute myeloid leukemia (AML), but its clinical efficacy as a single agent or in combination with hypomethylating agents (HMAs), such as azacitidine, is hampered by intrinsic and acquired resistance. Here, we performed a genome...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aax2863

    authors： Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM

    更新日期：2019-10-30 00:00:00

  • Astrocytes light up glial heterogeneity.

    abstract：:Functionally diverse subpopulations of astrocytes have correlates in the neoplastic adult brain. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aam9858

    authors： Venere M

    更新日期：2017-03-01 00:00:00

  • Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer.

    abstract：:KRAS represents an excellent therapeutic target in lung cancer, the most commonly mutated form of which can now be blocked using KRAS-G12C mutant-specific inhibitory trial drugs. Lung adenocarcinoma cells harboring KRAS mutations have been shown previously to be selectively sensitive to inhibition of mitogen-activated...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaw7999

    authors： Molina-Arcas M,Moore C,Rana S,van Maldegem F,Mugarza E,Romero-Clavijo P,Herbert E,Horswell S,Li LS,Janes MR,Hancock DC,Downward J

    更新日期：2019-09-18 00:00:00

  • CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors.

    abstract：:Tumor cells engineered to express therapeutic agents have shown promise to treat cancer. However, their potential to target cell surface receptors specific to the tumor site and their posttreatment fate have not been explored. We created therapeutic tumor cells expressing ligands specific to primary and recurrent tumo...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aao3240

    authors： Reinshagen C,Bhere D,Choi SH,Hutten S,Nesterenko I,Wakimoto H,Le Roux E,Rizvi A,Du W,Minicucci C,Shah K

    更新日期：2018-07-11 00:00:00

  • Complexity in common diseases: big biology for all.

    abstract：:The Commentary of Mills and Sykes in Science Translational Medicine presented their thesis on the advent of high-throughput technologies and the dangers they may represent for the future of biomedical research. In response, we argue that true progress on the diagnosis and treatment of common human diseases will requir...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.3000882

    authors： Lamb JR,Gibson NW

    更新日期：2010-03-31 00:00:00

  • The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

    abstract：:Patients undergoing surgical resection of primary breast tumors confront a risk for metastatic recurrence that peaks sharply 12 to 18 months after surgery. The cause of early metastatic relapse in breast cancer has long been debated, with many ascribing these relapses to the natural progression of the disease. Others ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aan3464

    authors： Krall JA,Reinhardt F,Mercury OA,Pattabiraman DR,Brooks MW,Dougan M,Lambert AW,Bierie B,Ploegh HL,Dougan SK,Weinberg RA

    更新日期：2018-04-11 00:00:00

  • Serotonergic neurons mediate dyskinesia side effects in Parkinson's patients with neural transplants.

    abstract：:Troublesome involuntary movements in the absence of dopaminergic medication, so-called off-medication dyskinesias, are a serious adverse effect of fetal neural grafts that hinders the development of cell-based therapies for Parkinson's disease. The mechanisms underlying these dyskinesias are not well understood, and i...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3000976

    authors： Politis M,Wu K,Loane C,Quinn NP,Brooks DJ,Rehncrona S,Bjorklund A,Lindvall O,Piccini P

    更新日期：2010-06-30 00:00:00

  • Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel.

    abstract：:The AAA+ adenosine triphosphatase (ATPase) Thorase plays a critical role in controlling synaptic plasticity by regulating the expression of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Bidirectional sequencing of exons of ATAD1, the gene encoding Thorase, in a cohort of patients wit...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aah4985

    authors： Umanah GKE,Pignatelli M,Yin X,Chen R,Crawford J,Neifert S,Scarffe L,Behensky AA,Guiberson N,Chang M,Ma E,Kim JW,Castro CC,Mao X,Chen L,Andrabi SA,Pletnikov MV,Pulver AE,Avramopoulos D,Bonci A,Valle D,Dawson TM,

    更新日期：2017-12-13 00:00:00

  • Survivin is a therapeutic target in Merkel cell carcinoma.

    abstract：:Merkel cell polyomavirus (MCV) causes ~80% of primary and metastatic Merkel cell carcinomas (MCCs). By comparing digital transcriptome subtraction deep-sequencing profiles, we found that transcripts of the cellular survivin oncoprotein [BIRC5a (baculoviral inhibitor of apoptosis repeat-containing 5)] were up-regulated...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3003713

    authors： Arora R,Shuda M,Guastafierro A,Feng H,Toptan T,Tolstov Y,Normolle D,Vollmer LL,Vogt A,Dömling A,Brodsky JL,Chang Y,Moore PS

    更新日期：2012-05-09 00:00:00

  • Drug effectiveness explained: the mathematics of antiviral agents for HIV.

    abstract：:Antiretroviral therapy has improved the quality and length of life of millions of individuals affected by human immunodeficiency virus type 1 (HIV-1). The capacity of these drugs to indefinitely suppress HIV-which has a well-known capacity for escaping antiviral pressures-is surprising. In this issue of Science Transl...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.3002656

    authors： Perelson AS,Deeks SG

    更新日期：2011-07-13 00:00:00

  • Thrombin contributes to cancer immune evasion via proteolysis of platelet-bound GARP to activate LTGF-β.

    abstract：:Cancer-associated thrombocytosis and high concentrations of circulating transforming growth factor-β1 (TGF-β1) are frequently observed in patients with progressive cancers. Using genetic and pharmacological approaches, we show a direct link between thrombin catalytic activity and release of mature TGF-β1 from platelet...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aay4860

    authors： Metelli A,Wu BX,Riesenberg B,Guglietta S,Huck JD,Mills C,Li A,Rachidi S,Krieg C,Rubinstein MP,Gewirth DT,Sun S,Lilly MB,Wahlquist AH,Carbone DP,Yang Y,Liu B,Li Z

    更新日期：2020-01-08 00:00:00

  • The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.

    abstract：:Studies have suggested a role for the mammalian (or mechanistic) target of rapamycin (mTOR) in skeletal development and homeostasis, yet there is no evidence connecting mTOR with the key signaling pathways that regulate skeletogenesis. We identified a parathyroid hormone (PTH)/PTH-related peptide (PTHrP)-salt-inducibl...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aat9356

    authors： Csukasi F,Duran I,Barad M,Barta T,Gudernova I,Trantirek L,Martin JH,Kuo CY,Woods J,Lee H,Cohn DH,Krejci P,Krakow D

    更新日期：2018-09-19 00:00:00

  • Design of vaccine efficacy trials during public health emergencies.

    abstract：:Public health emergencies, such as an Ebola disease outbreak, provide a complex and challenging environment for the evaluation of candidate vaccines. Here, we outline the need for flexible and responsive vaccine trial designs to be used in public health emergencies, and we summarize recommendations for their use in th...

    journal_title：Science translational medicine

    pub_type： 杂志文章,评审

    doi：10.1126/scitranslmed.aat0360

    authors： Dean NE,Gsell PS,Brookmeyer R,De Gruttola V,Donnelly CA,Halloran ME,Jasseh M,Nason M,Riveros X,Watson CH,Henao-Restrepo AM,Longini IM

    更新日期：2019-07-03 00:00:00

  • Using health information technology to engage communities in health, education, and research.

    abstract：:The August 2011 Clinical and Translational Science Awards conference "Using IT to Improve Community Health: How Health Care Reform Supports Innovation" convened four "Think Tank" sessions. Thirty individuals, representing various perspectives on community engagement, attended the "Health information technology (HIT) a...

    journal_title：Science translational medicine

    pub_type：

    doi：10.1126/scitranslmed.3003363

    authors： Marriott LK,Nelson DA,Allen S,Calhoun K,Eldredge CE,Kimminau KS,Lucero RJ,Pineda-Reyes F,Rumala BB,Varanasi AP,Wasser JS,Shannon J

    更新日期：2012-02-01 00:00:00

  • Translational cancer research comes of age in Latin America.

    abstract：:The U.S.-Latin America Cancer Research Network strives to expand translational research capabilities and forge new collaborations. ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aad5859

    authors： Investigators of the US–Latin America Cancer Research Network.

    更新日期：2015-12-23 00:00:00

  • Advancing translational research collaborations.

    abstract：:In February 2010, the U.S. National Institutes of Health (NIH) sponsored a national Clinical and Translational Science Awards forum titled "Promoting Efficient and Effective Collaborations among Academia, Government and Industry." This forum brought together a broad set of stakeholders who were charged with developing...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3001636

    authors： Portilla LM,Evans G,Eng B,Fadem TJ

    更新日期：2010-12-22 00:00:00

  • Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody.

    abstract：:Nipah virus (NiV) is an emerging zoonotic paramyxovirus that causes severe and often fatal disease in pigs and humans. There are currently no vaccines or treatments approved for human use. Studies in small-animal models of NiV infection suggest that antibody therapy may be a promising treatment. However, most studies ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3008929

    authors： Geisbert TW,Mire CE,Geisbert JB,Chan YP,Agans KN,Feldmann F,Fenton KA,Zhu Z,Dimitrov DS,Scott DP,Bossart KN,Feldmann H,Broder CC

    更新日期：2014-06-25 00:00:00

  • Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.

    abstract：:Recent studies have established the involvement of the fat mass and obesity-associated gene (FTO) in metabolic disorders such as obesity and diabetes. However, the precise molecular mechanism by which FTO regulates metabolism remains unknown. Here, we used a structure-based virtual screening of U.S. Food and Drug Admi...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aau7116

    authors： Peng S,Xiao W,Ju D,Sun B,Hou N,Liu Q,Wang Y,Zhao H,Gao C,Zhang S,Cao R,Li P,Huang H,Ma Y,Wang Y,Lai W,Ma Z,Zhang W,Huang S,Wang H,Zhang Z,Zhao L,Cai T,Zhao YL,Wang F,Nie Y,Zhi G,Yang YG,Zhang EE,

    更新日期：2019-04-17 00:00:00

  • More than baby steps: perspectives on pediatric translational research.

    abstract：:Although children represent 25% of the U.S. population and nearly 40% of the world's population, pediatric product development typically lags behind that targeted at adults. Here the authors describe the challenges and opportunities of pediatric product development and the unique issues that surround pediatric researc...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3000152

    authors： Connor E,Lombardi D,van den Anker J

    更新日期：2009-10-14 00:00:00

  • Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.

    abstract：:Cardiac rhythm is extremely robust, generating 2 billion contraction cycles during the average human life span. Transcriptional control of cardiac rhythm is poorly understood. We found that removal of the transcription factor gene Tbx5 from the adult mouse caused primary spontaneous and sustained atrial fibrillation (...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aaf4891

    authors： Nadadur RD,Broman MT,Boukens B,Mazurek SR,Yang X,van den Boogaard M,Bekeny J,Gadek M,Ward T,Zhang M,Qiao Y,Martin JF,Seidman CE,Seidman J,Christoffels V,Efimov IR,McNally EM,Weber CR,Moskowitz IP

    更新日期：2016-08-31 00:00:00

  • Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.

    abstract：:Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of nonhuman...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aad3231

    authors： Furlan SN,Watkins B,Tkachev V,Flynn R,Cooley S,Ramakrishnan S,Singh K,Giver C,Hamby K,Stempora L,Garrett A,Chen J,Betz KM,Ziegler CG,Tharp GK,Bosinger SE,Promislow DE,Miller JS,Waller EK,Blazar BR,Kean LS

    更新日期：2015-11-25 00:00:00

  • In vivo liquid biopsy using Cytophone platform for photoacoustic detection of circulating tumor cells in patients with melanoma.

    abstract：:Most cancer deaths arise from metastases as a result of circulating tumor cells (CTCs) spreading from the primary tumor to vital organs. Despite progress in cancer prognosis, the role of CTCs in early disease diagnosis is unclear because of the low sensitivity of CTC assays. We demonstrate the high sensitivity of the ...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aat5857

    authors： Galanzha EI,Menyaev YA,Yadem AC,Sarimollaoglu M,Juratli MA,Nedosekin DA,Foster SR,Jamshidi-Parsian A,Siegel ER,Makhoul I,Hutchins LF,Suen JY,Zharov VP

    更新日期：2019-06-12 00:00:00

  • Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody.

    abstract：:As observed during the 2013-2016 Ebola virus disease epidemic, containment of filovirus outbreaks is challenging and made more difficult by the lack of approved vaccine or therapeutic options. Marburg and Ravn viruses are highly virulent and cause severe and frequently lethal disease in humans. Monoclonal antibodies (...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.aai8711

    authors： Mire CE,Geisbert JB,Borisevich V,Fenton KA,Agans KN,Flyak AI,Deer DJ,Steinkellner H,Bohorov O,Bohorova N,Goodman C,Hiatt A,Kim DH,Pauly MH,Velasco J,Whaley KJ,Crowe JE Jr,Zeitlin L,Geisbert TW

    更新日期：2017-04-05 00:00:00

  • A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge.

    abstract：:Long-acting GSK1265744 (GSK744 LA) is a strand transfer inhibitor of the HIV/SIV (simian immunodeficiency virus) integrase and was shown to be an effective preexposure prophylaxis (PrEP) agent in a low-dose intrarectal SHIV (simian-human immunodeficiency virus) rhesus macaque challenge model. We examined the pharmacok...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3010298

    authors： Andrews CD,Yueh YL,Spreen WR,St Bernard L,Boente-Carrera M,Rodriguez K,Gettie A,Russell-Lodrigue K,Blanchard J,Ford S,Mohri H,Cheng-Mayer C,Hong Z,Ho DD,Markowitz M

    更新日期：2015-01-14 00:00:00

  • Vitamin C puts the pedal to the metal.

    abstract：:Increased iron in cancer cells drives selective sensitization of tumors to ascorbate treatment to prolong survival. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aan2778

    authors： Venere M

    更新日期：2017-04-12 00:00:00

  • Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR.

    abstract：:MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base pairing with 3' untranslated regions, primarily via seed sequences (nucleotides 2 to 8 in the mature miRNA sequence). A number of individual miRNAs and miRNA families share seed sequenc...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3006840

    authors： Rottiers V,Obad S,Petri A,McGarrah R,Lindholm MW,Black JC,Sinha S,Goody RJ,Lawrence MS,deLemos AS,Hansen HF,Whittaker S,Henry S,Brookes R,Najafi-Shoushtari SH,Chung RT,Whetstine JR,Gerszten RE,Kauppinen S,Näär AM

    更新日期：2013-11-20 00:00:00

  • Self-tanning cells, the new SPF.

    abstract：:A skin-penetrant small molecule activates melanin production to protect cells from cancer-inducing ultraviolet damage. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aan8202

    authors： Venere M

    更新日期：2017-07-05 00:00:00

  • KLF6-SV1 drives breast cancer metastasis and is associated with poor survival.

    abstract：:Metastasis is the major cause of cancer mortality. A more thorough understanding of the mechanisms driving this complex multistep process will aid in the identification and characterization of therapeutically targetable genetic drivers of disease progression. We demonstrate that KLF6-SV1, an oncogenic splice variant o...

    journal_title：Science translational medicine

    pub_type： 杂志文章

    doi：10.1126/scitranslmed.3004688

    authors： Hatami R,Sieuwerts AM,Izadmehr S,Yao Z,Qiao RF,Papa L,Look MP,Smid M,Ohlssen J,Levine AC,Germain D,Burstein D,Kirschenbaum A,DiFeo A,Foekens JA,Narla G

    更新日期：2013-01-23 00:00:00

  • Working stiff: how obesity boosts cancer risk.

    abstract：:Obesity promotes breast cancer by enhancing the stiffness of breast adipose tissue through changes in the extracellular matrix (Seo et al., this issue). ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aac9446

    authors： Arendt LM,Kuperwasser C

    更新日期：2015-08-19 00:00:00

  • Surf's up for ER stress.

    abstract：:A new type of biological clock regulates the unfolded protein response. ...

    journal_title：Science translational medicine

    pub_type： 评论,杂志文章

    doi：10.1126/scitranslmed.aan6728

    authors： Haspel J

    更新日期：2017-06-28 00:00:00