Grease fires turn up the heat in autoimmune disease.


:Restoring reverse cholesterol transport ameliorates the B cell hyperexpansion and autoimmune disease found to be associated with accumulation of cholesterol in CD11c+ antigen-presenting cells.


Sci Transl Med


Bhakta NR




Has Abstract


2017-01-25 00:00:00












  • DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates.

    abstract::DEL-1 (developmental endothelial locus-1) is an endothelial cell-secreted protein that regulates LFA-1 (lymphocyte function-associated antigen-1) integrin-dependent leukocyte recruitment and inflammation in various tissues. We identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we sho...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Shin J,Maekawa T,Abe T,Hajishengallis E,Hosur K,Pyaram K,Mitroulis I,Chavakis T,Hajishengallis G

    更新日期:2015-09-30 00:00:00

  • Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.

    abstract::Lung cancer is more deadly than colon, breast, and prostate cancers combined, and treatment improvements have failed to improve prognosis significantly. Here, we identify a critical mediator of lung cancer progression, Rac1b, a tumor-associated protein with cell-transforming properties that are linked to the matrix me...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Stallings-Mann ML,Waldmann J,Zhang Y,Miller E,Gauthier ML,Visscher DW,Downey GP,Radisky ES,Fields AP,Radisky DC

    更新日期:2012-07-11 00:00:00

  • Translating glutamate: from pathophysiology to treatment.

    abstract::The neurotransmitter glutamate is the primary excitatory neurotransmitter in mammalian brain and is responsible for most corticocortical and corticofugal neurotransmission. Disturbances in glutamatergic function have been implicated in the pathophysiology of several neuropsychiatric disorders-including schizophrenia, ...

    journal_title:Science translational medicine

    pub_type: 杂志文章,评审


    authors: Javitt DC,Schoepp D,Kalivas PW,Volkow ND,Zarate C,Merchant K,Bear MF,Umbricht D,Hajos M,Potter WZ,Lee CM

    更新日期:2011-09-28 00:00:00

  • Striatal dopamine regulates systemic glucose metabolism in humans and mice.

    abstract::The brain is emerging as an important regulator of systemic glucose metabolism. Accumulating data from animal and observational human studies suggest that striatal dopamine signaling plays a role in glucose regulation, but direct evidence in humans is currently lacking. We present a series of experiments supporting th...

    journal_title:Science translational medicine

    pub_type: 杂志文章,随机对照试验


    authors: Ter Horst KW,Lammers NM,Trinko R,Opland DM,Figee M,Ackermans MT,Booij J,van den Munckhof P,Schuurman PR,Fliers E,Denys D,DiLeone RJ,la Fleur SE,Serlie MJ

    更新日期:2018-05-23 00:00:00

  • Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.

    abstract::Asthma is a clinically heterogeneous genetic disease, and its pathogenesis is incompletely understood. Genome-wide association studies link ORM (yeast)-Like protein isoform 3 [corrected] (ORMDL3), a member of the ORM gene family, to nonallergic childhood-onset asthma. Orm proteins negatively regulate sphingolipid (SL)...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Worgall TS,Veerappan A,Sung B,Kim BI,Weiner E,Bholah R,Silver RB,Jiang XC,Worgall S

    更新日期:2013-05-22 00:00:00

  • Surf's up for ER stress.

    abstract::A new type of biological clock regulates the unfolded protein response. ...

    journal_title:Science translational medicine

    pub_type: 评论,杂志文章


    authors: Haspel J

    更新日期:2017-06-28 00:00:00

  • One size does not fit all: Size-based plasma DNA diagnostics.

    abstract::Understanding the biological properties of plasma cell-free DNA may expand its applications in oncology (Mouliere et al, this issue). ...

    journal_title:Science translational medicine

    pub_type: 评论,杂志文章,评审


    authors: Heitzer E,Speicher MR

    更新日期:2018-11-07 00:00:00

  • Programmable probiotics for detection of cancer in urine.

    abstract::Rapid advances in the forward engineering of genetic circuitry in living cells has positioned synthetic biology as a potential means to solve numerous biomedical problems, including disease diagnosis and therapy. One challenge in exploiting synthetic biology for translational applications is to engineer microbes that ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Danino T,Prindle A,Kwong GA,Skalak M,Li H,Allen K,Hasty J,Bhatia SN

    更新日期:2015-05-27 00:00:00

  • Affinity-based design of a synthetic universal reversal agent for heparin anticoagulants.

    abstract::Heparin-based anticoagulant drugs have been widely used for the prevention of blood clotting during surgical procedures and for the treatment of thromboembolic events. However, bleeding risks associated with these anticoagulants demand continuous monitoring and neutralization with suitable antidotes. Protamine, the on...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Shenoi RA,Kalathottukaren MT,Travers RJ,Lai BF,Creagh AL,Lange D,Yu K,Weinhart M,Chew BH,Du C,Brooks DE,Carter CJ,Morrissey JH,Haynes CA,Kizhakkedathu JN

    更新日期:2014-10-29 00:00:00

  • Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States.

    abstract::Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections to date has relied heavily on reverse transcription polymerase chain reaction testing. However, limited test availability, high false-negative rates, and the existence of asymptomatic or subclinical infections have resulted in an unde...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Silverman JD,Hupert N,Washburne AD

    更新日期:2020-07-29 00:00:00

  • Improving the spatial resolution of epiretinal implants by increasing stimulus pulse duration.

    abstract::Retinal prosthetic implants are the only approved treatment for retinitis pigmentosa, a disease of the eye that causes blindness through gradual degeneration of photoreceptors. An array of microelectrodes triggered by input from a camera stimulates surviving retinal neurons, with each electrode acting as a pixel. Unin...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Weitz AC,Nanduri D,Behrend MR,Gonzalez-Calle A,Greenberg RJ,Humayun MS,Chow RH,Weiland JD

    更新日期:2015-12-16 00:00:00

  • Integrating physical sciences perspectives in cancer research.

    abstract::Cancer research integrated a physical sciences perspective through team science, which fostered communication, trust, joint publication, and open access to data. ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Kuhn NZ,Nagahara LA

    更新日期:2013-05-01 00:00:00

  • Hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channels drive pain in mouse models of diabetic neuropathy.

    abstract::Diabetic patients frequently suffer from continuous pain that is poorly treated by currently available analgesics. We used mouse models of type 1 and type 2 diabetes to investigate a possible role for the hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2) ion channels as drivers of diabetic pain. Blocking or...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Tsantoulas C,Laínez S,Wong S,Mehta I,Vilar B,McNaughton PA

    更新日期:2017-09-27 00:00:00

  • Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is estimated to affect up to one-third of the general population, and new therapies are urgently required. Our laboratory previously developed a controlled-release mitochondrial protonophore (CRMP) that is functionally liver-targeted and promotes oxidation of hepatic triglyceri...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Goedeke L,Peng L,Montalvo-Romeral V,Butrico GM,Dufour S,Zhang XM,Perry RJ,Cline GW,Kievit P,Chng K,Petersen KF,Shulman GI

    更新日期:2019-10-02 00:00:00

  • A long-acting integrase inhibitor protects female macaques from repeated high-dose intravaginal SHIV challenge.

    abstract::Long-acting GSK1265744 (GSK744 LA) is a strand transfer inhibitor of the HIV/SIV (simian immunodeficiency virus) integrase and was shown to be an effective preexposure prophylaxis (PrEP) agent in a low-dose intrarectal SHIV (simian-human immunodeficiency virus) rhesus macaque challenge model. We examined the pharmacok...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Andrews CD,Yueh YL,Spreen WR,St Bernard L,Boente-Carrera M,Rodriguez K,Gettie A,Russell-Lodrigue K,Blanchard J,Ford S,Mohri H,Cheng-Mayer C,Hong Z,Ho DD,Markowitz M

    更新日期:2015-01-14 00:00:00

  • Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

    abstract::Pathological angiogenesis is the hallmark of diseases such as cancer and retinopathies. Although tissue hypoxia and inflammation are recognized as central drivers of vessel growth, relatively little is known about the process that bridges the two. In a mouse model of ischemic retinopathy, we found that hypoxic regions...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Oubaha M,Miloudi K,Dejda A,Guber V,Mawambo G,Germain MA,Bourdel G,Popovic N,Rezende FA,Kaufman RJ,Mallette FA,Sapieha P

    更新日期:2016-10-26 00:00:00

  • An extracorporeal bioartificial liver embedded with 3D-layered human liver progenitor-like cells relieves acute liver failure in pigs.

    abstract::Clinical advancement of the bioartificial liver is hampered by the lack of expandable human hepatocytes and appropriate bioreactors and carriers to encourage hepatic cells to function during extracorporeal circulation. We have recently developed an efficient approach for derivation of expandable liver progenitor-like ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Li WJ,Zhu XJ,Yuan TJ,Wang ZY,Bian ZQ,Jing HS,Shi X,Chen CY,Fu GB,Huang WJ,Shi YP,Liu Q,Zeng M,Zhang HD,Wu HP,Yu WF,Zhai B,Yan HX

    更新日期:2020-07-08 00:00:00

  • Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure.

    abstract::Urea, the toxic end product of protein catabolism, is elevated in end-stage renal disease (ESRD), although it is unclear whether or how it contributes to disease. Urea can promote the carbamylation of proteins on multiple lysine side chains, including human albumin, which has a predominant carbamylation site on Lys(54...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Berg AH,Drechsler C,Wenger J,Buccafusca R,Hod T,Kalim S,Ramma W,Parikh SM,Steen H,Friedman DJ,Danziger J,Wanner C,Thadhani R,Karumanchi SA

    更新日期:2013-03-06 00:00:00

  • Mechanobiologically optimized 3D titanium-mesh scaffolds enhance bone regeneration in critical segmental defects in sheep.

    abstract::Three-dimensional (3D) titanium-mesh scaffolds offer many advantages over autologous bone grafting for the regeneration of challenging large segmental bone defects. Our study supports the hypothesis that endogenous bone defect regeneration can be promoted by mechanobiologically optimized Ti-mesh scaffolds. Using finit...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Pobloth AM,Checa S,Razi H,Petersen A,Weaver JC,Schmidt-Bleek K,Windolf M,Tatai AÁ,Roth CP,Schaser KD,Duda GN,Schwabe P

    更新日期:2018-01-10 00:00:00

  • Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation.

    abstract::Clinical diagnostic tools requiring direct sample testing cannot be applied to infections deep within the body, and clinically available imaging tools lack specificity. New approaches are needed for early diagnosis and monitoring of bacterial infections and rapid detection of drug-resistant organisms. Molecular imagin...

    journal_title:Science translational medicine

    pub_type: 杂志文章,评审


    authors: Ordonez AA,Sellmyer MA,Gowrishankar G,Ruiz-Bedoya CA,Tucker EW,Palestro CJ,Hammoud DA,Jain SK

    更新日期:2019-09-04 00:00:00

  • Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma.

    abstract::Defects in tumor-intrinsic interferon (IFN) signaling result in failure of immune checkpoint blockade (ICB) against cancer, but these tumors may still maintain sensitivity to T cell-based adoptive cell therapy (ACT). We generated models of IFN signaling defects in B16 murine melanoma observed in patients with acquired...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Kalbasi A,Tariveranmoshabad M,Hakimi K,Kremer S,Campbell KM,Funes JM,Vega-Crespo A,Parisi G,Champekar A,Nguyen C,Torrejon D,Shin D,Zaretsky JM,Damoiseaux RD,Speiser DE,Lopez-Casas PP,Quintero M,Ribas A

    更新日期:2020-10-14 00:00:00

  • Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

    abstract::A preventive HIV-1 vaccine should induce HIV-1-specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to acquire breadth, and current vaccine strategies have not been successful in inducing bnAbs. Because bnAbs directed against a glycosylated site ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Bonsignori M,Kreider EF,Fera D,Meyerhoff RR,Bradley T,Wiehe K,Alam SM,Aussedat B,Walkowicz WE,Hwang KK,Saunders KO,Zhang R,Gladden MA,Monroe A,Kumar A,Xia SM,Cooper M,Louder MK,McKee K,Bailer RT,Pier BW,Jette CA

    更新日期:2017-03-15 00:00:00

  • miRNA processing and human cancer: DICER1 cuts the mustard.

    abstract::Numerous studies have implicated microRNAs (miRNAs) in cancer initiation and progression. In contrast, only recently has attention been focused on the pathway that generates these regulatory molecules. The identification of neoplasia-associated germline mutations in DICER1 has focused translational research on compone...

    journal_title:Science translational medicine

    pub_type: 杂志文章,评审


    authors: Bahubeshi A,Tischkowitz M,Foulkes WD

    更新日期:2011-11-30 00:00:00

  • AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.

    abstract::Next-generation sequencing technologies have greatly expanded our understanding of cancer genetics. Antisense technology is an attractive platform with the potential to translate these advances into improved cancer therapeutics, because antisense oligonucleotide (ASO) inhibitors can be designed on the basis of gene se...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Hong D,Kurzrock R,Kim Y,Woessner R,Younes A,Nemunaitis J,Fowler N,Zhou T,Schmidt J,Jo M,Lee SJ,Yamashita M,Hughes SG,Fayad L,Piha-Paul S,Nadella MV,Mohseni M,Lawson D,Reimer C,Blakey DC,Xiao X,Hsu J,Revenko A

    更新日期:2015-11-18 00:00:00

  • A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.

    abstract::Buprenorphine, a synthetic opioid that acts at both μ and κ opioid receptors, can decrease cocaine use in individuals with opioid addiction. However, the potent agonist action of buprenorphine at μ opioid receptors raises its potential for creating opioid dependence in non-opioid-dependent cocaine abusers. Here, we te...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Wee S,Vendruscolo LF,Misra KK,Schlosburg JE,Koob GF

    更新日期:2012-08-08 00:00:00

  • Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates.

    abstract::Reactivation of fetal hemoglobin (HbF) is being pursued as a treatment strategy for hemoglobinopathies. Here, we evaluated the therapeutic potential of hematopoietic stem and progenitor cells (HSPCs) edited with the CRISPR-Cas9 nuclease platform to recapitulate naturally occurring mutations identified in individuals w...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Humbert O,Radtke S,Samuelson C,Carrillo RR,Perez AM,Reddy SS,Lux C,Pattabhi S,Schefter LE,Negre O,Lee CM,Bao G,Adair JE,Peterson CW,Rawlings DJ,Scharenberg AM,Kiem HP

    更新日期:2019-07-31 00:00:00

  • Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.

    abstract::Arrhythmogenic cardiomyopathy (ACM) is characterized by frequent cardiac arrhythmias. To elucidate the underlying mechanisms and discover potential chemical modifiers, we created a zebrafish model of ACM with cardiac myocyte-specific expression of the human 2057del2 mutation in the gene encoding plakoglobin. A high-th...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Asimaki A,Kapoor S,Plovie E,Karin Arndt A,Adams E,Liu Z,James CA,Judge DP,Calkins H,Churko J,Wu JC,MacRae CA,Kléber AG,Saffitz JE

    更新日期:2014-06-11 00:00:00

  • Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing.

    abstract::Fibroblasts are primary cellular protagonists of wound healing. They also exhibit circadian timekeeping, which imparts an approximately 24-hour rhythm to their biological function. We interrogated the functional consequences of the cell-autonomous clockwork in fibroblasts using a proteome-wide screen for rhythmically ...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Hoyle NP,Seinkmane E,Putker M,Feeney KA,Krogager TP,Chesham JE,Bray LK,Thomas JM,Dunn K,Blaikley J,O'Neill JS

    更新日期:2017-11-08 00:00:00

  • Epidermal EGFR controls cutaneous host defense and prevents inflammation.

    abstract::The epidermal growth factor receptor (EGFR) plays an important role in tissue homeostasis and tumor progression. However, cancer patients treated with EGFR inhibitors (EGFRIs) frequently develop acneiform skin toxicities, which are a strong predictor of a patient's treatment response. We show that the early inflammato...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Lichtenberger BM,Gerber PA,Holcmann M,Buhren BA,Amberg N,Smolle V,Schrumpf H,Boelke E,Ansari P,Mackenzie C,Wollenberg A,Kislat A,Fischer JW,Röck K,Harder J,Schröder JM,Homey B,Sibilia M

    更新日期:2013-08-21 00:00:00

  • Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer.

    abstract::Therapeutic intravesical instillation of bacillus Calmette-Guérin (BCG) is effective at triggering inflammation and eliciting successful tumor immunity in patients with non-muscle invasive bladder cancer, with 50 to 70% clinical response. Therapeutic success relies on repeated instillations of live BCG administered as...

    journal_title:Science translational medicine

    pub_type: 杂志文章


    authors: Biot C,Rentsch CA,Gsponer JR,Birkhäuser FD,Jusforgues-Saklani H,Lemaître F,Auriau C,Bachmann A,Bousso P,Demangel C,Peduto L,Thalmann GN,Albert ML

    更新日期:2012-06-06 00:00:00