Abstract：
:Previously three imaging methods, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), T(1ρ )-MRI, and low temperature NADH/Fp (reduced nicotinamide adenine dinucleotide/oxidized flavoprotein) fluorescence imaging (redox scanning)were reported to differentiate the mouse xenografts of a less metastatic human melanoma cell line A375P and a more metastatic line C8161. The more metastatic melanoma is characterized by less blood perfusion/permeability and more oxidized mitochondrial redox state in the tumor core and lower T(1ρ ) relaxation time averaged across the tumor section. These features may be useful for identifying imaging biomarkers for cancer metastatic potential. Here, we have employed T(1ρ )- and T2-weighted MRI to image mouse xenografts of two human breast cancer lines (more metastatic MDA-MB-231 and less metastatic MDA-MB-468) on a vertical bore 9.4- T Varian MR system. The preliminary results indicated that the more metastatic MDA-MB-231 tumors had shorter T(xρ ) relaxation constants on average than the less metastatic MDA-MB-468 tumors, and T(xρ ) relaxation might be a potential biomarker of breast tumor metastatic potential. Distinct ring-like structures were observed on T(xρ )-weighted MR images of the breast tumors, indicating tumor core and rim difference. This observation appears to be consistent with the tumor core-rim difference previously observed by DCE-MRI and redox scanning on aggressive melanoma xenografts.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Li LZ,Xu HN,Reddy Rdoi
10.1007/978-1-4419-7756-4_19subject
Has Abstractpub_date
2011-01-01 00:00:00pages
137-42eissn
0065-2598issn
2214-8019journal_volume
701pub_type
杂志文章abstract：:Epigenetic mechanisms, which include DNA methylation, histone modification, and microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA sequence. Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various other maladies. M...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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abstract：:Melanoma and nonmelanoma skin cancer (NMSC) are now the most common types of cancer in white populations. Both tumor entities show an increasing incidence rate worldwide but a stable or decreasing mortality rate. The rising incidence rates of NMSC are probably caused by a combination of increased sun exposure or expos...
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abstract：:The ability to serially collect blood samples and conduct ultrasound examinations in Asian and African elephants has provided unique opportunities to study the biology of these endangered species. As a result, many unique aspects of elephant reproduction have been identified. For females, there are interesting differe...
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journal_title：Advances in experimental medicine and biology
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doi：10.1007/5584_2016_12
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-0-387-78885-2_3
更新日期：2008-01-01 00:00:00
abstract：:Even though stroke is the third, not the first, most common cause of disability-adjusted life years in developed countries, it is one of the most expensive to treat. Part of the expense is due to secondary problems in the post-stroke period including: cognition, memory, attention span, pain, sensation loss, psychologi...
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journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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abstract：:In the previous chapter we were able to automatically process text by recognizing a limited set of entities. This chapter will introduce the world of semantics, and present step-by-step examples to retrieve and enhance text and data processing by using semantics. The goal is to equip the reader with the basic set of s...
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abstract：:Smith-Lemli-Opitz Syndrome (SLOS) is a recessive hereditary disease caused by a defect in the last step in cholesterol biosynthesis - the reduction of the Delta7 double bond of 7-dehydrocholesterol (7DHC) - resulting in the abnormal accumulation of 7DHC and diminished levels of Chol in all bodily tissues. Treatment of...
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更新日期：2010-01-01 00:00:00
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更新日期：2010-01-01 00:00:00
abstract：:Clostridium difficile infection (CDI) is one of the most common healthcare-associated infections in the world and is a leading cause of morbidity and mortality in hospitalized patients.Although several antibiotics effectively treat CDI, some individuals do not respond to these drugs and may be cured by transplanting s...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
doi：10.1007/978-3-319-72799-8_11
更新日期：2018-01-01 00:00:00
abstract：:The identification and characterization of microRNAs (miRNAs) is a rapidly growing area of research also in dermatology. Skin represents the largest organ in the human body, and its morphogenesis has been shown to require a highly coordinated and undisrupted miRNA profile. High expression of several miRNAs in the epid...
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
abstract：:Myocardial ischemia and reperfusion cause injury to the heart in myocardial ischemic disease. Both processes increase autophagy. In this chapter, we will provide an overview of the autophagic mechanism caused by myocardial ischemia/reperfusion injury and the role of autophagy in myocardial ischemia/reperfusion injury....
journal_title：Advances in experimental medicine and biology
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
