The dopamine agonist bromocriptine differentially affects fronto-striatal functional connectivity during working memory.

Abstract:

:We investigated the effect of bromocriptine, a dopamine agonist, on individual differences in behavior as well as frontal-striatal connectivity during a working memory task. After dopaminergic augmentation, frontal-striatal connectivity in low working memory capacity individuals increases, corresponding with behavioral improvement whereas decreases in connectivity in high working memory capacity individuals are associated with poorer behavioral performance. These findings corroborate an inverted U-shape response of dopamine function in behavioral performance and provide insight on the corresponding neural mechanisms.

journal_name

Front Hum Neurosci

authors

Wallace DL,Vytlacil JJ,Nomura EM,Gibbs SE,D'Esposito M

doi

10.3389/fnhum.2011.00032

subject

Has Abstract

pub_date

2011-03-31 00:00:00

pages

32

issn

1662-5161

journal_volume

5

pub_type

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