Abstract:
:Individuals with autism show difficulties in using sentence context to identify the correct meaning of ambiguous words, such as homonyms. In this study, the brain basis of sentence context effects on word understanding during reading was examined in autism spectrum disorder (ASD) and typical development (TD) using magnetoencephalography. The correlates of a history of developmental language delay in ASD were also investigated. Event related field responses at early (150 ms after the onset of a final word) and N400 latencies are reported for three different types of sentence final words: dominant homonyms, subordinate homonyms, and unambiguous words. Clear evidence for semantic access was found at both early and conventional N400 latencies in both TD participants and individuals with ASD with no history of language delay. By contrast, modulation of evoked activity related to semantic access was weak and not significant at early latencies in individuals with ASD with a history of language delay. The reduced sensitivity to semantic context in individuals with ASD and language delay was accompanied by strong right hemisphere lateralization at early and N400 latencies; such strong activity was not observed in TD individuals and individuals with ASD without a history of language delay at either latency. These results provide new evidence and support for differential neural mechanisms underlying semantic processing in ASD, and indicate that delayed language acquisition in ASD is associated with different lateralization and processing of language.
journal_name
Front Hum Neuroscijournal_title
Frontiers in human neuroscienceauthors
Ahtam B,Braeutigam S,Bailey Adoi
10.3389/fnhum.2020.00267subject
Has Abstractpub_date
2020-07-10 00:00:00pages
267issn
1662-5161journal_volume
14pub_type
杂志文章abstract::Carriers of the fragile X premutation allele (fXPCs) have an expanded CGG trinucleotide repeat size within the FMR1 gene and are at increased risk of developing fragile x-associated tremor/ataxia syndrome (FXTAS). Previous research has shown that male fXPCs with FXTAS exhibit cognitive decline, predominantly in execut...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2015.00037
更新日期:2015-02-05 00:00:00
abstract::The prospect of enhancing cognition is undoubtedly among the most exciting research questions currently bridging psychology, neuroscience, and evidence-based medicine. Yet, convincing claims in this line of work stem from designs that are prone to several shortcomings, thus threatening the credibility of training-indu...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00153
更新日期:2016-04-14 00:00:00
abstract::Maintaining equilibrium while riding a horse is a challenging task that involves complex sensorimotor processes. We evaluated the relative contribution of visual information (static or dynamic) to horseback riders' postural stability (measured from the variability of segment position in space) and the coordination mod...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00011
更新日期:2017-01-30 00:00:00
abstract::The relationship between blood oxygenation level dependent-functional magnetic resonance imaging (BOLD-fMRI) and magnetoencephalography (MEG) metrics were explored using low-level visual stimuli known to elicit a rich variety of neural responses. Stimuli were either perceptually isoluminant red/green or luminance-modu...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00076
更新日期:2013-03-11 00:00:00
abstract::Background: Autism spectrum disorder (ASD) is associated with persistent impairments in adaptive functioning across multiple domains of daily life. Thus, investigation of the biological background of both adaptive and maladaptive behaviors may shed light on developing effective interventions for improving social adapt...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00005
更新日期:2019-01-22 00:00:00
abstract::Amongst the most significant questions we are confronted with today include the integration of the brain's micro-circuitry, our ability to build the complex social networks that underpin society and how our society impacts on our ecological environment. In trying to unravel these issues one place to begin is at the le...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2013.00852
更新日期:2013-12-17 00:00:00
abstract::The right inferior fronto-parietal network monitors the current status of the musculoskeletal system and builds-up and updates our postural model. The kinesthetic illusion induced by tendon vibration has been utilized in experiments on the modulation of body awareness. The right inferior fronto-parietal cortices activ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00330
更新日期:2019-09-24 00:00:00
abstract::Prior research with preschool children has established that dialogic or active book reading is an effective method for expanding young children's vocabulary. In this exploratory study, we asked whether similar benefits are observed when a robot engages in dialogic reading with preschoolers. Given the established effec...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00295
更新日期:2017-06-07 00:00:00
abstract::Phonological awareness skills in children with reading difficulty (RD) may reflect impaired automatic integration of orthographic and phonological representations. However, little is known about the underlying neural mechanisms involved in phonological awareness for children with RD. Eighteen children with RD, ages 9-...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00390
更新日期:2019-11-14 00:00:00
abstract::[This corrects the article on p. 673 in vol. 8, PMID: 25221500.]. ...
journal_title:Frontiers in human neuroscience
pub_type: 已发布勘误
doi:10.3389/fnhum.2014.00923
更新日期:2014-11-14 00:00:00
abstract::Healthy aging is typically accompanied by some decline in cognitive performance, as well as by alterations in brain structure and function. Here we report the results of a randomized, controlled trial designed to determine the effects of a novel cognitive training program on resting cerebral blood flow (CBF) and gray ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.09.016.2010
更新日期:2010-03-12 00:00:00
abstract::In experimental psychology different experiments have been developed to assess goal-directed as compared to habitual control over instrumental decisions. Similar to animal studies selective devaluation procedures have been used. More recently sequential decision-making tasks have been designed to assess the degree of ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00587
更新日期:2014-08-04 00:00:00
abstract::Elderly depressed patients manifest pronounced executive dysfunction compared with younger subjects with depressive disorder. Aging-related brain changes may result in executive dysfunction in geriatric depression. We investigated the neural correlates of inhibitory control processing in depressed subjects at differen...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00116
更新日期:2016-03-30 00:00:00
abstract:OBJECTIVES:The objective of this post-hoc exploratory analysis was to examine the relationship between age and measures of cortical excitability and inhibition. METHODS:Forty-six participants (24 with major depressive disorder and 22 healthy controls) completed MT, SICI, ICF, and CSP testing in a cross-sectional proto...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00669
更新日期:2014-09-02 00:00:00
abstract::Applying a precisely timed pulse of transcranial magnetic stimulation (TMS) over the right posterior parietal cortex (PPC) can produce temporary visuo-spatial neglect-like effects. Although the TMS is applied over PPC, it is not clear what other brain regions are involved. We applied TMS within a functional magnetic r...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2012.00326
更新日期:2012-12-17 00:00:00
abstract::Part of the process of EEG microstate estimation involves clustering EEG channel data at the global field power (GFP) maxima, very commonly using a modified K-means approach. Clustering has also been done deterministically, despite there being uncertainties in multiple stages of the microstate analysis, including the ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00534
更新日期:2017-11-01 00:00:00
abstract::The ability to detect small changes in one's visual environment is important for effective adaptation to and interaction with a wide variety of external stimuli. Much research has studied the auditory mismatch negativity (MMN), or the brain's automatic response to rare changes in a series of repetitive auditory stimul...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00922
更新日期:2013-12-30 00:00:00
abstract::The present study investigated the relationship between verbal and visuospatial working memory (WM) capacity and long-range regression (i.e., word relocation) processes in reading. We analyzed eye movements during a "whodunit task", in which readers were asked to answer a content question while original text was being...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00765
更新日期:2014-09-29 00:00:00
abstract::Anodal transcranial direct current stimulation (tDCS) over the motor cortex is considered a potential treatment for motor rehabilitation following stroke and other neurological pathologies. However, both the context under which this stimulation is effective and the underlying mechanisms remain to be determined. In thi...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00384
更新日期:2016-08-05 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) plays an important role in neuroplasticity and promotes axonal growth, but its secretion, regulated by a BDNF gene, declines with age. The low-activity (met) allele of common polymorphism BDNF val66met is associated with reduced production of BDNF. We examined whether age-relat...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/neuro.09.019.2009
更新日期:2009-08-20 00:00:00
abstract::Converging behavioral and functional neuroimaging evidence indicates that East Asian and Western individuals have different orientations for processing information that may stem from contrasting cultural values. In this cross-cultural magnetic resonance imaging (MRI) study, we used voxel-based morphometry (VBM) approa...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2019.00313
更新日期:2019-09-10 00:00:00
abstract::Highly mobile computing devices promise to improve quality of life, productivity, and performance. Increased situation awareness and reduced mental workload are two potential means by which this can be accomplished. However, it is difficult to measure these concepts in the "wild". We employed ultra-portable battery op...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00216
更新日期:2016-05-18 00:00:00
abstract::The prefrontal cortex (PFC) is the most frequently targeted brain region by non-invasive brain stimulation (NBS) studies. Non-invasively stimulating the PFC has been shown to both modulate affective processing and improve the clinical symptoms of several psychiatric disorders, such as depression and schizophrenia. The...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2017.00439
更新日期:2017-09-04 00:00:00
abstract::The judgement of human ability is ubiquitous, from school admissions to job performance reviews. The exact make-up of ability traits, however, is often narrowly defined and lacks a comprehensive basis. We attempt to simplify the spectrum of human ability, similar to how five personality traits are widely believed to d...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2020.609170
更新日期:2020-12-16 00:00:00
abstract::Increase in postural-demand resources does not necessarily degrade a concurrent motor task, according to the adaptive resource-sharing hypothesis of postural-suprapostural dual-tasking. This study investigated how brain networks are organized to optimize a suprapostural motor task when the postural load increases and ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2016.00420
更新日期:2016-08-19 00:00:00
abstract::For individuals who are blind, navigating independently in an unfamiliar environment represents a considerable challenge. Inspired by the rising popularity of video games, we have developed a novel approach to train navigation and spatial cognition skills in adolescents who are blind. Audio-based Environment Simulator...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2014.00133
更新日期:2014-03-11 00:00:00
abstract::Neuroimaging combined with transcranial magnetic stimulation (TMS) to primary motor cortex (M1) is an emerging technique that can examine motor-system functionality through evoked activity. However, because sensory afferents from twitching muscles are widely represented in motor areas the amount of evoked activity dir...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2013.00554
更新日期:2013-09-17 00:00:00
abstract::The prevalence of obesity skyrocketed over the past decades to become a significant public health problem. Obesity is recognized as a low-grade inflammatory disease and is linked with several comorbidities such as diabetes, circulatory disease, common neurodegenerative diseases, as well as chronic pain. Adipocytes are...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章,评审
doi:10.3389/fnhum.2020.00181
更新日期:2020-06-09 00:00:00
abstract::Performance-related feedback plays an important role in improving human being's adaptive behavior. Using event-related potentials (ERPs), previous studies have associated a particular component, i.e., reward positivity (RewP), with outcome evaluation processing and found that this component was affected by waiting tim...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2018.00020
更新日期:2018-01-25 00:00:00
abstract::Some years ago Cheung et al. (2008) proposed the complete design (CD) for measuring the failure of selective attention in composite objects. Since the CD is a fully balanced design, analysis of response bias may reveal potential effects of the experimental manipulation, the stimulus material, and/or attributes of the ...
journal_title:Frontiers in human neuroscience
pub_type: 杂志文章
doi:10.3389/fnhum.2017.00494
更新日期:2017-10-17 00:00:00