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Developmental aspects of cortical excitability and inhibition in depressed and healthy youth: an exploratory study.

Abstract：

OBJECTIVES:The objective of this post-hoc exploratory analysis was to examine the relationship between age and measures of cortical excitability and inhibition. METHODS:Forty-six participants (24 with major depressive disorder and 22 healthy controls) completed MT, SICI, ICF, and CSP testing in a cross-sectional protocol. Of these 46 participants, 33 completed LICI testing. Multiple linear robust regression and Spearman partial correlation coefficient were used to examine the relationship between age and the TMS measures. RESULTS:In the overall sample of 46 participants, age had a significant negative relationship with motor threshold (MT) in both the right (r s = -0.49, adjusted p = 0.007; β = -0.08, adjusted p = 0.001) and left (r s = -0.42, adjusted p = 0.029; β = -0.05, adjusted p = 0.004) hemispheres. This significant negative relationship of age with MT was also observed in the sample of depressed youth in both the right (r s = -0.70, adjusted p = 0.002; β = -0.09, adjusted p = 0.001) and left (r s = -0.54, adjusted p = 0.034; β = -0.05, adjusted p = 0.017) hemispheres, but not in healthy controls. In the sample of the 33 participants who completed LICI testing, age had a significant negative relationship with LICI (200 ms interval) in both the right (r s = -0.48, adjusted p = 0.05; β = -0.24, adjusted p = 0.007) and left (r s = -0.64, adjusted p = 0.002; β = -0.23, adjusted p = 0.001) hemispheres. This negative relationship between age and LICI (200 ms interval) was also observed in depressed youth in both the right (r s = -0.76, adjusted p = 0.034; β = -0.35, adjusted p = 0.004) and left (r s = -0.92, adjusted p = 0.002; β = -0.25, adjusted p = 0.001) hemispheres. CONCLUSION:These findings suggest that younger children have higher MTs. This is more pronounced in depressed youth than healthy controls. LICI inhibition may also increase with age in youth.

journal_name

Front Hum Neurosci

journal_title

Frontiers in human neuroscience

authors

Croarkin PE,Nakonezny PA,Lewis CP,Zaccariello MJ,Huxsahl JE,Husain MM,Kennard BD,Emslie GJ,Daskalakis ZJ

doi

10.3389/fnhum.2014.00669

subject

Has Abstract

pub_date

2014-09-02 00:00:00

pages

669

issn

1662-5161

journal_volume

pub_type

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Developmental aspects of cortical excitability and inhibition in depressed and healthy youth: an exploratory study.