Abstract:
BACKGROUND:Biofilm formation has been implicated as an etiologic factor in the development of chronic rhinosinusitis (CRS). Nasal irrigation with surfactants including dilute baby shampoo have been proposed as an antibiofilm treatment for CRS patients. The effect of dilute baby shampoo on normal sinonasal mucosal function is unknown. METHODS:Mucociliary clearance time (MCT), as measured by the time in minutes for a subject to detect a sweet taste after the application of a saccharin granules at the anterior part of the inferior turbinate, was performed before and shortly after nasal irrigation with 50 ml of 1% baby shampoo (Johnson & Johnson, New Brunswick, NJ) in 27 healthy volunteers. RESULTS:Mean MCTs before and after irrigation were 12.09 (±4.83 minutes) and 15.45 (±7.71 minutes) minutes, respectively. The mean difference, 3.37 minutes, was statistically significant (p = 0.031). Pre- and post-MCTs for each subject were not correlated (r = 0.324; p = 0.100). CONCLUSION:Nasal irrigations with dilute baby shampoo increase MCTs in healthy subjects. The impact of such interventions in CRS patients warrants additional investigation.
journal_name
Am J Rhinol Allergyjournal_title
American journal of rhinology & allergyauthors
Isaacs S,Fakhri S,Luong A,Whited C,Citardi MJdoi
10.2500/ajra.2011.25.3583subject
Has Abstractpub_date
2011-01-01 00:00:00pages
e27-9issue
1eissn
1945-8924issn
1945-8932journal_volume
25pub_type
杂志文章abstract:BACKGROUND:Chronic rhinosinusitis (CRS) is recognized as a common disease that imposes a big burden on the health system worldwide. There is ongoing evidence of the anti-inflammatory effect of long-term macrolide in the management of patients with CRS. OBJECTIVE:The aim of this randomized clinical trial was to evaluat...
journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2015-11-01 00:00:00
abstract::Background The cribriform plate (CP) is a common site of spontaneous cerebrospinal fluid (SCSF) leaks. Radiographic assessment of the anterior and lateral skull base has shown thinner bone in patients with SCSFs; however, prior assessment of the CP has required postmortem cadaver dissection. Objective To develop novel...
journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2010-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
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journal_title:American journal of rhinology & allergy
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更新日期:2010-09-01 00:00:00
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journal_title:American journal of rhinology & allergy
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.1177/1945892420933173
更新日期:2021-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2009.23.3314
更新日期:2009-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2016.30.4276
更新日期:2016-03-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,随机对照试验
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更新日期:2013-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2010.24.3394
更新日期:2010-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章,评审
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更新日期:2015-05-01 00:00:00
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journal_title:American journal of rhinology & allergy
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更新日期:2017-07-01 00:00:00
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journal_title:American journal of rhinology & allergy
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更新日期:2020-09-11 00:00:00
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journal_title:American journal of rhinology & allergy
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更新日期:2014-07-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2016.30.4353
更新日期:2016-09-01 00:00:00
abstract::Background Since the Food and Drug Administration approval of balloon sinuplasty (BSP) in 2005, no nationally representative population-based studies have examined the outcomes and adverse events of BSP. Objective To assess the rates of complications and revision surgery in patients who received BSP, functional endosc...
journal_title:American journal of rhinology & allergy
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更新日期:2018-09-01 00:00:00
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journal_title:American journal of rhinology & allergy
pub_type: 杂志文章
doi:10.2500/ajra.2011.25.3638
更新日期:2011-09-01 00:00:00