The effect of dilute baby shampoo on nasal mucociliary clearance in healthy subjects.

Abstract:

BACKGROUND:Biofilm formation has been implicated as an etiologic factor in the development of chronic rhinosinusitis (CRS). Nasal irrigation with surfactants including dilute baby shampoo have been proposed as an antibiofilm treatment for CRS patients. The effect of dilute baby shampoo on normal sinonasal mucosal function is unknown. METHODS:Mucociliary clearance time (MCT), as measured by the time in minutes for a subject to detect a sweet taste after the application of a saccharin granules at the anterior part of the inferior turbinate, was performed before and shortly after nasal irrigation with 50 ml of 1% baby shampoo (Johnson & Johnson, New Brunswick, NJ) in 27 healthy volunteers. RESULTS:Mean MCTs before and after irrigation were 12.09 (±4.83 minutes) and 15.45 (±7.71 minutes) minutes, respectively. The mean difference, 3.37 minutes, was statistically significant (p = 0.031). Pre- and post-MCTs for each subject were not correlated (r = 0.324; p = 0.100). CONCLUSION:Nasal irrigations with dilute baby shampoo increase MCTs in healthy subjects. The impact of such interventions in CRS patients warrants additional investigation.

journal_name

Am J Rhinol Allergy

authors

Isaacs S,Fakhri S,Luong A,Whited C,Citardi MJ

doi

10.2500/ajra.2011.25.3583

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

e27-9

issue

1

eissn

1945-8924

issn

1945-8932

journal_volume

25

pub_type

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