Nitrite attenuates ischemia-reperfusion-induced microcirculatory alterations and mitochondrial dysfunction in the microvasculature of skeletal muscle.

Abstract:

BACKGROUND:Recently, nitrite has been rediscovered as a physiologically relevant storage reservoir of nitric oxide in blood and it can readily be converted to nitric oxide under hypoxic and acidic conditions. In this study, the authors evaluated the therapeutic efficacy of nitrite on reperfusion-induced microcirculatory alterations and mitochondrial dysfunction in the microvasculature of skeletal muscle. METHODS:The authors used a vascular pedicle isolated rat cremaster model that underwent 4 hours of warm ischemia followed by 2 hours or 17 hours of reperfusion. At 5 minutes before reperfusion, normal saline, sodium nitrite (0.20 μM/minute/kg), or nitrite mixed with 2-(4-carboxyphenyl)-4,5-dihydro-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl (potassium salt) (0.2 mg/minute/kg) was infused into the microcirculation of ischemic cremaster by means of intraarterial infusion. Ischemia-reperfusion-induced microcirculatory alterations were measured after 2 hours of reperfusion. Microvasculature of the cremaster muscle including the vascular pedicle was harvested to determine the mitochondrial dysfunction. The blood concentration of methemoglobin was also measured to determine the toxicity of nitrite. RESULTS:The authors found that nitrite significantly attenuated ischemia-reperfusion-induced vasoconstriction, arteriole stagnation, and capillary no-reflow in the early phase of reperfusion and the depolarization of mitochondrial membrane potential and cytochrome c release in the late phase of reperfusion. Nitrite-induced protection was significantly blocked by a nitric oxide scavenger (potassium salt). The methemoglobin results showed that the doses of nitrite we used in the present study were safe. CONCLUSION:The supplementation of a low dose of nitrite, directly into the microcirculation of ischemic muscle through local intraarterial infusion, significantly attenuated ischemia-reperfusion-induced microcirculatory alterations in vivo and mitochondrial dysfunction in vitro in the microvasculature of skeletal muscle.

journal_name

Plast Reconstr Surg

authors

Wang WZ,Fang XH,Stephenson LL,Zhang X,Williams SJ,Baynosa RC,Khiabani KT,Zamboni WA

doi

10.1097/PRS.0b013e3182268b9a

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

279e-287e

issue

4

eissn

0032-1052

issn

1529-4242

pii

00006534-201110000-00012

journal_volume

128

pub_type

杂志文章
  • A nationwide curriculum analysis of integrated plastic surgery training: is training standardized?

    abstract:BACKGROUND:The integrated model of plastic surgery education, shortly to become the standard for all 6-year programs, has set minimal but no maximal exposure to plastic surgery. The authors hypothesized that the first 3 years of integrated training will show variability among residency programs. METHODS:Rotation sched...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182a8089c

    authors: Schneider LF,Barr J,Saadeh PB

    更新日期:2013-12-01 00:00:00

  • A multiphase system bone implant for regenerating the calvaria.

    abstract::The regeneration of bone with a biodegradable, biocompatible carrier and osteo-regenerative proteins may be possible if the carrier has the appropriate architecture to support osteoconduction and prevent soft-tissue prolapse into ablated bone segments. Using radiomorphometry and histomorphometry, our group assessed in...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199304000-00002

    authors: Kleinschmidt JC,Marden LJ,Kent D,Quigley N,Hollinger JO

    更新日期:1993-04-01 00:00:00

  • Voice reconstruction with free ileocolon flap transfer: implications for the lower respiratory tract.

    abstract:BACKGROUND:Free ileocolon flap surgery is an effective technique for voice reconstruction in hypopharyngolaryngectomy defects. A tracheoesophageal fistula is created using an intestinal conduit characterized by secretions and a resident microbial flora. The aim of this study was to investigate the respiratory complicat...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31820cf282

    authors: Rampazzo A,Gharb BB,di Spilimbergo SS,Chung KP,Chen HC

    更新日期:2011-05-01 00:00:00

  • Breast reconstruction with the latissimus dorsi flap: women's preference for scar location.

    abstract:BACKGROUND:Refinements made in latissimus dorsi breast reconstruction have improved the aesthetic appearance of the breast without changing the donor-site location. The optimal location for donor-site placement, from a patient's perspective, is still unknown. The purpose of this study was to assess women's preference f...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181de1b41

    authors: Bailey S,Saint-Cyr M,Zhang K,Mojallal A,Wong C,Ouyang D,Maia M,Zhang S,Rohrich RJ

    更新日期:2010-08-01 00:00:00

  • Measuring outcomes in aesthetic surgery: a comprehensive review of the literature.

    abstract::Outcomes research examines the end results of medical interventions, taking into account patients' experiences, preferences, and values. The purpose of assessing outcomes is to provide evidence on which to base clinical decisions. The assessment of outcomes in aesthetic surgery is especially pertinent because patient ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,meta分析

    doi:10.1097/01.PRS.0000036041.67101.48

    authors: Ching S,Thoma A,McCabe RE,Antony MM

    更新日期:2003-01-01 00:00:00

  • Current surgical management of bilateral cleft lip in North America.

    abstract:BACKGROUND:This study was undertaken to determine contemporary surgical management of bilateral cleft lip. METHODS:A survey was sent to North American cleft surgeons. Variables included number of bilateral cleft lip repairs per year, surgical specialty, and methods of nasolabial correction. The authors analyzed possib...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/PRS.0b013e31824ecbd3

    authors: Tan SPK,Greene AK,Mulliken JB

    更新日期:2012-06-01 00:00:00

  • Elastin fibers in scar tissue.

    abstract::Scar tissue, obtained from humans, was stained for elastin fibers by a new staining method. Elastin fibers were noted at sites where they must have been formed de novo. The morphology and the distribution of elastin in various types of scars are described. Practically no elastin was found in keloids. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197603000-00005

    authors: Bhangoo KS,Quinlivan JK,Connelly JR

    更新日期:1976-03-01 00:00:00

  • New method of preparing a pectoralis major myocutaneous flap with a skin paddle that includes the third intercostal perforating branch of the internal thoracic artery.

    abstract:BACKGROUND:Although the use of free flaps has become a major option for head and neck reconstruction, the pectoralis major myocutaneous flap still plays an important role because of its advantages and its convenience as a pedicle flap located adjacent to head and neck lesions. However, there remain two problems with th...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e31819f2967

    authors: Rikimaru H,Kiyokawa K,Watanabe K,Koga N,Nishi Y,Sakamoto A

    更新日期:2009-04-01 00:00:00

  • Plastic surgeon's life: marvelous for mind, exhausting for body.

    abstract::Surgery is accepted as one of the most demanding professions that create both physical and mental strain on the performers. Therefore, the authors aimed to elucidate the mental burden of surgeons, which is dedicated to operative stress. They also tested the hypotheses that participating in surgery creates mental stres...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000133166.50279.7c

    authors: Demirtas Y,Tulmac M,Yavuzer R,Yalcin R,Ayhan S,Latifoglu O,Atabay K

    更新日期:2004-09-15 00:00:00

  • Repair of a lower leg defect with an ipsilateral gracilis myocutaneous flap.

    abstract::We report the use of a gracilis myocutaneous flap from the same thigh to repair a defect of the lower leg. This could be a useful alternative in well selected cases. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197910000-00032

    authors: Shubailat GF,Ajluni NJ,Shahateet MA

    更新日期:1979-10-01 00:00:00

  • Improving flap survival by sustaining cell metabolism within ischemic cells: a study using rabbits.

    abstract::Allopurinol, acting as a metabolic depressant, significantly increases flap survival in high doses, but not at doses that might be acceptable clinically. Prednisolone is highly effective in improving flap survival when the afferent blood supply is provided by small arteries such as are found in the panniculus carnosus...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198001000-00011

    authors: Mes LG

    更新日期:1980-01-01 00:00:00

  • Simultaneous Scalp, Skull, Kidney, and Pancreas Transplant from a Single Donor.

    abstract:BACKGROUND:Vascularized composite allotransplantation is an emerging field, but the complications of lifelong immunosuppression limit indications. Vascularized composite allotransplantation in solid organ recipients represents a unique opportunity because immunosuppression has already been accepted. This report of a si...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000002153

    authors: Selber JC,Chang EI,Clemens MW,Gaber L,Hanasono MM,Klebuc M,Skoracki RJ,Trask T,Yu P,Gaber AO

    更新日期:2016-06-01 00:00:00

  • Reduction mammaplasty: a significant improvement at any size.

    abstract:BACKGROUND:Reduction mammaplasty has been shown to be efficacious in reducing the burden of symptoms and improving the quality of life for patients with macromastia. However, most insurance carriers will not reimburse for mammaplasties involving less than 1000 g of total tissue resected. To refute this arbitrary policy...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000277660.49802.76

    authors: Spector JA,Karp NS

    更新日期:2007-09-15 00:00:00

  • A simple reconstruction for congenital unilateral lower lip palsy.

    abstract:BACKGROUND:Congenital unilateral lower lip palsy or congenital hypoplasia of the depressor anguli oris muscle, also known as asymmetric crying facies, characterized by deformity of the lower lip, lacks aggressive surgical intervention methods. Although several dynamic and static reconstruction methods have been reporte...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000264062.64251.10

    authors: Udagawa A,Arikawa K,Shimizu S,Suzuki H,Matsumoto H,Yoshimoto S,Ichinose M

    更新日期:2007-07-01 00:00:00

  • Computerized tomography and B-scan ultrasonography in the diagnosis of fractures of the medial orbital wall.

    abstract::Ultrasound and CT scans have been used to examine 12 patients with suspected medial orbital wall fractures. A good correlation between ultrasound and CT scanning was demonstrated, and the authors believe that either investigation is a suitable alternative to conventional radiology when this type of injury is suspected...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198103000-00001

    authors: Ord RA,Le May M,Duncan JG,Moos KF

    更新日期:1981-03-01 00:00:00

  • Cytomegalovirus and other infectious issues related to face transplantation: specific considerations, lessons learned, and future recommendations.

    abstract:BACKGROUND:Composite tissue allotransplantation is fraught with complexities similar to those of solid organ transplantation, including donor-related cytomegalovirus transmission. With this in mind, the authors' objective was to (1) report their team's experience with infections and donor-related cytomegalovirus transm...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318208d03c

    authors: Gordon CR,Avery RK,Abouhassan W,Siemionow M

    更新日期:2011-04-01 00:00:00

  • Pearls and pitfalls of needle aponeurotomy in Dupuytren's disease.

    abstract:BACKGROUND:Dupuytren's disease is a benign, progressive, fibroproliferative disease, and despite advances in basic science and technology, there remains no cure. To date, open fasciectomy procedures remain the criterion standard for the treatment of Dupuytren's disease despite a significant complication rate and recove...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000000961

    authors: Morhart M

    更新日期:2015-03-01 00:00:00

  • In vitro murine posterior frontal suture fate is age-dependent: implications for cranial suture biology.

    abstract::In CD-1 mice, the posterior frontal suture (analogous to the human metopic suture) fuses while all other cranial sutures remain patent. In an in vitro organ culture model, the authors previously demonstrated that posterior frontal sutures explanted immediately before the onset of suture fusion (at 25 days old) mimic i...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000110203.90911.63

    authors: Song HM,Sahar DE,Fong KD,Nacamuli RP,Fang TD,Mathy JA,Aalami OO,Warren SM,Longaker MT

    更新日期:2004-04-01 00:00:00

  • Transconjunctival blepharoplasty for upper and lower eyelids.

    abstract:BACKGROUND:Transconjunctival blepharoplasty remains a popular and safe technique to treat periorbital aging. In the lower lid, it can be used successfully for orbital fat excision, redistribution, or septal tightening. In the upper lid, transconjunctival blepharoplasty has a role in removal of the nasal fat pad via an ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181c2a534

    authors: Pacella SJ,Nahai FR,Nahai F

    更新日期:2010-01-01 00:00:00

  • A clinical evaluation of the results of submusculo-aponeurotic dissection and fixation in face lifts.

    abstract::In 25 random patients undergoing rhytidectomy, we did unilateral subplatysmal-fascial dissections of the superficial musculoaponeurotic system (SMAS) of the face and neck--with redistribution of the tension of this system and fixation by suturing. Late evaluation of these patients by 3 observers showed no detectable d...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197712000-00002

    authors: Rees TD,Aston SJ

    更新日期:1977-12-01 00:00:00

  • Method for intraoperative positioning of the nipple-areola complex in vertical scar reduction mammaplasty.

    abstract::The desired shape and position of the nipple-areola complex may be difficult to achieve in vertical scar reduction mammaplasty when using the standard technique of preoperative marking of the so-called mosque-shaped areolar pattern of excision. We describe our modified approach of intraoperative final positioning of t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200005000-00028

    authors: Vogt PM,Mühlberger T,Torres A,Peter FW,Steinau HU

    更新日期:2000-05-01 00:00:00

  • A simplified method for air drill irrigation.

    abstract::A modified No. 20 Foley catheter provides a simple, inexpensive method for intraoperative air drill burr irrigation. ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198402000-00033

    authors: Horowitz J,Chuong R

    更新日期:1984-02-01 00:00:00

  • The pedicled descending branch muscle-sparing latissimus dorsi flap for breast reconstruction.

    abstract:BACKGROUND:The pedicled descending branch muscle-sparing latissimus dorsi flap with a transversely oriented skin paddle presents distinct advantages in breast reconstruction, including reduced donor-site morbidity and greater freedom of orientation of the skin paddle. This study reports the anatomical basis, surgical t...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181934838

    authors: Saint-Cyr M,Nagarkar P,Schaverien M,Dauwe P,Wong C,Rohrich RJ

    更新日期:2009-01-01 00:00:00

  • Does the degree of ptosis predict the degree of psychological morbidity in bariatric patients undergoing reconstruction?

    abstract:BACKGROUND:There is proven therapeutic benefit in bariatric surgery for obese patients. Successful bariatric surgery will result in massive weight loss and ptotic skin, which can cause significant functional and psychological problems. As the incidence of bariatric surgery increases, so will the demand for plastic surg...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/PRS.0000000000000695

    authors: Al-Hadithy N,Aditya H,Stewart K

    更新日期:2014-11-01 00:00:00

  • MicroRNA-21 affects proliferation and apoptosis by regulating expression of PTEN in human keloid fibroblasts.

    abstract:BACKGROUND:MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression in the progress of proliferation, differentiation, and apoptosis. A keloid is considered to be a type of benign tumor. The exact contribution of miRNAs in keloid fibroblasts remains largely unknown. METHODS:Loss and gain of f...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000577

    authors: Liu Y,Wang X,Yang D,Xiao Z,Chen X

    更新日期:2014-10-01 00:00:00

  • Follow-Up Study: One-Step Salvage of Infected Prosthetic Breast Reconstructions Using Antibiotic-Impregnated Polymethylmethacrylate Plates and Concurrent Tissue Expander Exchange.

    abstract:BACKGROUND:Periprosthetic infections represent major complications in breast reconstruction, frequently leading to expander-implant loss. No consensus regarding a management algorithm for attempted salvage currently exists. This study assessed outcomes of the authors' salvage protocol using an antibiotic-impregnated po...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000006501

    authors: Xue AS,Volk AS,DeGregorio VL,Jubbal KT,Bullocks JM,Izaddoost SA

    更新日期:2020-02-01 00:00:00

  • Comparison of hedgehog and patched-1 protein expression in the cranial sutures of craniosynostotic and wild-type rabbits.

    abstract::Craniosynostosis is characterized by premature fusion of the cranial sutures. At the molecular level, mutations in homeobox genes, transcription factors, and growth factor receptors have been implicated in the pathogenesis of this disorder, but the specific etiologic pathways have not yet been elucidated. To further s...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200208000-00023

    authors: Nott RL,Stelnicki EJ,Mack JA,Ben Y,Mitchell R,Mooney MP

    更新日期:2002-08-01 00:00:00

  • The Medial Sural Artery Perforator Flap: Lessons Learned from 200 Consecutive Cases.

    abstract:BACKGROUND:The medial sural artery perforator flap is a versatile option in reconstructive microsurgery. However, most reports of this flap have been limited by sample size. This study reviews the experience of a single large-volume center using the medial sural artery perforator flap and its variants for a variety of ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000007282

    authors: Deek NFA,Hsiao JC,Do NT,Kao HK,Hsu CC,Lin CH,Lin CH

    更新日期:2020-11-01 00:00:00

  • Analyzing Regional Differences over a 15-Year Trend of One-Stage versus Two-Stage Breast Reconstruction in 941,191 Postmastectomy Patients.

    abstract:BACKGROUND:Implant-based reconstruction is the predominant form of breast reconstruction, with the two-stage tissue expander/implant approach being the most popular. Recently, the direct-to-implant, one-stage breast reconstruction procedure has gained momentum. In this study, national and regional trends across the Uni...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000002267

    authors: Kamali P,Koolen PGL,Ibrahim AMS,Paul MA,Dikmans RE,Schermerhorn ML,Lee BT,Lin SJ

    更新日期:2016-07-01 00:00:00

  • Further evaluation of the potential of the argon laser in the treatment of strawberry hemangiomas.

    abstract::Six cases of strawberry hemangioma have been presented in which some form of intervention in tumor progression was indicated. The argon laser was used. All six cases showed loss of surface vascularity. Growth was clearly arrested in four of the six. Premature regression could be definitely claimed in only one. The str...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198304000-00005

    authors: Hobby LW

    更新日期:1983-04-01 00:00:00