Involvement of neutrophils in ischemia-reperfusion injury of inguinal island skin flaps in rats.


:Increased production of oxygen free radicals and infiltration of neutrophils into tissue subjected to ischemia-reperfusion have emphasized that neutrophils play a direct role in the development of injury. The present study was designed to elucidate the effect of FK506, a new immunosuppressive drug, on 11 hours of complete ischemia and reperfusion of the inguinal island skin flaps in rats. Group 1 (n = 10) control animals underwent ischemia and reperfusion and no treatment. Group 2 (n = 10) animals received FK 506 0.3 mg/kg/day, and group 3 (n = 9) animals received 0.5 mg/kg/day intramuscularly for 3 days before the ischemia. The effect of the drug was evaluated by measuring flap survival and tissue malondialdehyde content and myeloperoxidase activity and also by histopathologic examination of the skin specimens taken at the 1st and 24th hour after reperfusion. The survival of flaps controlled for 7 days was found to be significantly improved in group 2 (65.0 +/- 10.93 percent) and group 3 (93 +/- 6.25 percent) when compared with the control group (14 +/- 10.12 percent) (p < 0.04 and p < 0.0001). The tissue contents of malondialdehyde and activities of myeloperoxidase were significantly lower in groups 2 and 3 than in the control group. Three days of pretreatment with FK506 significantly reduced neutrophil infiltration in groups treated with either of the doses. These results showed that neutrophils play an important role in island flap survival associated with ischemia-reperfusion injury. Increased neutrophil infiltration was found related with increased levels of malondialdehyde and myeloperoxidase. Flap necrosis and the increase in malondialdehyde, myeloperoxidase, and neutrophil infiltration were improved by FK506 pretreatment, a neutrophil modulating agent.


Plast Reconstr Surg


Cetinkale O,Bilgic L,Bolayirli M,Sengul R,Ayan F,Burcak G




Has Abstract


1998-07-01 00:00:00












  • Use of the vascularized free fibula graft with an arteriovenous loop for fusion of cervical and thoracic spinal defects in previously irradiated pediatric patients.

    abstract:BACKGROUND:Extensive spinal neoplasms are difficult to manage. Following resection, arthrodesis of the spine can be performed with instrumentation, but this often fails in the setting of radiation therapy. Use of the free fibula flap for anterior spinal fusion to correct deformities has been described in multiple studi...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Jandali S,Diluna ML,Storm PB,Low DW

    更新日期:2011-05-01 00:00:00

  • Free flap from the flexor aspect of the wrist for resurfacing defects of the hand and fingers.

    abstract::The distal portion of the flexor aspect of the forearm has been used as the donor site of full-thickness skin grafts, venous skin grafts, and Chinese forearm flaps. This article describes the use of a free flap harvested from the flexor aspect of the wrist and based on the superficial palmar branch of the radial arter...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Sakai S

    更新日期:2003-04-01 00:00:00

  • Surgical techniques for a deep concha, a pseudomeatus, and high projection in congenital microtia.

    abstract::Some modified surgical techniques are described for constructing a deep conchal cavity and pseudomeatus and obtaining high auricular projection in congenital microtia. At the primary operation, a rather small portion of the microtic vestige is utilized for the lobule by switching, sparing the skin for the concha, with...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Isshiki N,Koyama H,Suzuki S,Taira T

    更新日期:1986-04-01 00:00:00

  • The thoracodorsal artery perforator flap in the treatment of axillary hidradenitis suppurativa: effect on preservation of arm abduction.

    abstract:UNLABELLED:Hidradenitis suppurativa is a chronic, recurrent inflammatory disease of the skin characterized by abscesses and scars. The axillary region is predominantly affected, leading to limited mobility of the arm due to scar retraction. This prospective study aimed to analyze the surgical treatment of severe lesion...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Busnardo FF,Coltro PS,Olivan MV,Busnardo APV,Ferreira MC

    更新日期:2011-10-01 00:00:00

  • Pathophysiology of cleft lip muscles following the initial surgical repair.

    abstract::Muscle biopsy specimens taken from the upper lip and perialar area during the time of secondary lip revision and studied by histochemical techniques demonstrate persistent connective-tissue and muscle abnormalities even at a distance from the cleft margins. Some of these changes are consistent with surgically induced ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Schendel SA,Pearl RM,De Armond SJ

    更新日期:1991-08-01 00:00:00

  • Squamous cell carcinoma of the skin.

    abstract:LEARNING OBJECTIVES:After studying this article, the participant should be able to: 1. Identify the subtypes of squamous cell carcinoma of the skin. 2. Identify factors that affect recurrence and/or metastasis. 3. Develop a surgical management plan for treating high-risk squamous cell carcinoma of the skin. In treating...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Rudolph R,Zelac DE

    更新日期:2004-11-01 00:00:00

  • Demonstration of actin in the fibroblasts of healing palatal wounds.

    abstract::The purpose of this study was to gain information which might be helpful in understanding the influence of palate surgery on abnormal maxillary growth. The finding of actin-rich cells in the granulation tissue of palatal wounds supports the hypothesis that one of the functions of those cells is contraction--and the la...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Dabelsteen E,Kremenak CR

    更新日期:1978-09-01 00:00:00

  • General anesthesia for rhytidectomy: a review of 100 consecutive cases.

    abstract::Although local anesthesia will, and should, continue to be the principal method of anesthesia for most face lift operations, we believe that general endotracheal anesthesia, supplemented by local anesthesia with epinephrine, offers significant advantages in a selected group of patients. We review 100 consecutive rhyti...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kaye BL,Kruse JC

    更新日期:1977-11-01 00:00:00

  • The Current Role of Three-Dimensional (3D) Printing in Plastic Surgery.

    abstract::Since the advent of three-dimensional (3D) printing in the 1980s, it is now possible to produce physical objects from digital files and create 3D objects by adding one layer at a time following a predetermined pattern. Due to the continued development of inexpensive and easy- to- use 3D printers and bioprinting, this ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kamali P,Dean D,Skoracki R,Koolen PG,Paul MA,Ibrahim AM,Lin SJ

    更新日期:2016-01-21 00:00:00

  • Free-flap free flap.

    abstract::We present a patient who sustained bilateral below-knee amputations that were treated with skin grafts as initial coverage. A latissimus dorsi free flap was later used as definitive coverage of one stump. Then at a subsequent operation a portion of the same latissimus dorsi free flap was reharvested, again as a free f...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Valauri FA,Alpert BS,Buncke HJ

    更新日期:1989-07-01 00:00:00

  • In vivo electrical conductivity across critical nerve gaps using poly(3,4-ethylenedioxythiophene)-coated neural interfaces.

    abstract:BACKGROUND:Bionic limbs require sensitive, durable, and physiologically relevant bidirectional control interfaces. Modern central nervous system interfacing is high risk, low fidelity, and failure prone. Peripheral nervous system interfaces will mitigate this risk and increase fidelity by greatly simplifying signal int...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Egeland BM,Urbanchek MG,Peramo A,Richardson-Burns SM,Martin DC,Kipke DR,Kuzon WM Jr,Cederna PS

    更新日期:2010-12-01 00:00:00

  • Comparison of polydioxanone and polyglactin 910 in intradermal repair.

    abstract::A prospective clinical study was undertaken to compare the results of intradermal layer closure using two popular absorbable suture materials, polydioxanone and polyglactin 910. On an alternating basis, 6-0 polydioxanone and 6-0 polyglactin 910 were used to repair 80 surgical sites of the temple and occipital regions ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章


    authors: Guyuron B,Vaughan C

    更新日期:1996-10-01 00:00:00

  • Fungal growth inside saline-filled implants and the role of injection ports in fungal translocation: in vitro study.

    abstract::Infection is a serious complication of breast augmentation and tissue expansion with inflatable devices. Several reports have shown that fungi may be able to survive, colonize, and even cause infection in saline-filled devices. The mechanism of how they penetrate, spread, and colonize inside the inflatable implants is...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Saray A,Kilic D,Kaygusuz S,Boyunaga H,Ozlük O

    更新日期:2004-10-01 00:00:00

  • Implantable venous Doppler microvascular monitoring: laboratory investigation and clinical results.

    abstract::The purpose of this study was to compare the sensitivity of a 20-mHz ultrasonic Doppler device to detect microvascular thrombosis placed on the vein with that placed on the artery. A feasibility study in animals preceded a comparative clinical study in patients. Six rabbits were used to develop a bilateral hind limb p...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Swartz WM,Izquierdo R,Miller MJ

    更新日期:1994-01-01 00:00:00

  • Predictors of readmission after outpatient plastic surgery.

    abstract:BACKGROUND:Hospital readmissions have become a topic of focus for quality care measures and cost-reduction efforts. However, no comparative multi-institutional data on plastic surgery outpatient readmission rates currently exist. The authors endeavored to investigate hospital readmission rates and predictors of readmis...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Mioton LM,Buck DW 2nd,Rambachan A,Ver Halen J,Dumanian GA,Kim JYS

    更新日期:2014-01-01 00:00:00

  • Surgical treatment for frontal baldness: the long temporal vertical flap.

    abstract::Not only is the long temporal vertical flap not centered on the temporosuperficial artery, but it is also countercurrent to this artery. The difficulties of its design are largely compensated for by the natural aspect of the anterior area once achieved. It must be emphasized that all techniques of transplantation can ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Nataf J

    更新日期:1984-11-01 00:00:00

  • Cross-Sectional Soft-Tissue Composition and the Distribution of Blue Cutaneous Discoloration in the Lower Eyelid after Hyaluronic Acid Injection.

    abstract::The soft-tissue composition of the eyelid varies from lateral to medial, in that the orbicularis area (in square millimeters) is greatest medially and least laterally, whereas the reverse is true for the preauricularis and postorbicularis fat. The purpose of this study was to describe the relative contribution of tiss...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Essilfie JO,Kattan J,Demer JL,Rootman DB

    更新日期:2019-08-01 00:00:00

  • The sit-up position for breast reconstruction.

    abstract::For breast reconstruction, we have found that breast symmetry can be created optimally when the patient is brought to a totally upright position with the trunk vertical and perpendicular to the floor. The size of the opposite breast can better be appreciated. Nipple and areola position can be determined accurately eve...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Smoot EC,Ross D,Silverberg B,Ruttle M,Newman LM

    更新日期:1986-01-01 00:00:00

  • Paranasal implants for correction of midface concavity.

    abstract::Central midface concavity was corrected with the placement of porous polyethylene implants in the paranasal area. This simulated the effect of skeletal osteotomies and advancement without altering dental occlusion. Implants were placed to correct congenital, posttraumatic, and cleft-related skeletal midface retrusion ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Yaremchuk MJ,Israeli D

    更新日期:1998-10-01 00:00:00

  • Management of Vascular Anomalies and Related Conditions Using Suction-Assisted Tissue Removal.

    abstract:UNLABELLED:Vascular anomalies and related conditions cause overgrowth of tissues. The purpose of this study was to determine the efficacy and safety of liposuction techniques for pediatric overgrowth diseases. Patients treated between 2007 and 2015 who had follow-up were reviewed. Seventeen patients were included; the ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Couto JA,Maclellan RA,Greene AK

    更新日期:2015-10-01 00:00:00

  • Experimental study and clinical use of the fasciosteal flap.

    abstract::Thirty-seven domestic rabbits, 4 dogs, and 2 freshly amputated human limbs were divided into three groups as three different models of fasciosteal flaps that were taken from the distal radii or the tibiae. Through the methods of histology, fluorochrome bone labeling, and perfusing stain, it was confirmed that viabilit...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Shi ZM,Xu ZG

    更新日期:1986-08-01 00:00:00

  • Breast reconstruction using the sensate latissimus dorsi musculocutaneous flap.

    abstract::The authors performed immediate breast reconstruction on four patients using a sensate latissimus dorsi musculocutaneous flap accompanied by neurorrhaphy during the past 6 years. In the neurorrhaphy, the lateral cutaneous branch of the dorsal primary divisions of the seventh thoracic nerve, which controls the sensatio...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Yano K,Hosokawa K,Takagi S,Nakai K,Kubo T

    更新日期:2002-05-01 00:00:00

  • Breast cancer diagnosis and survival in women with and without breast implants.

    abstract::The stage at diagnosis and the survival experience of 41 women who developed breast cancer after cosmetic breast augmentation were compared with those of all other patients with breast cancer (n = 13,246) diagnosed in Alberta from 1973 to 1990 (inclusive). The tumors in women with breast implants were smaller (65.9 pe...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Birdsell DC,Jenkins H,Berkel H

    更新日期:1993-10-01 00:00:00

  • The psychological aspects of cosmetic breast augmentation.

    abstract:BACKGROUND:The psychological aspects of cosmetic breast augmentation have been the focus of a great deal of empiric study over the past 40 years. METHODS:Studies investigating the preoperative characteristics and psychosocial status of women interested in breast augmentation are reviewed. Investigations of postoperati...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审


    authors: Sarwer DB

    更新日期:2007-12-01 00:00:00

  • Sterile "ready-to-use" AlloDerm decreases postoperative infectious complications in patients undergoing immediate implant-based breast reconstruction with acellular dermal matrix.

    abstract:BACKGROUND:Acellular dermal matrix is a commonly used adjunct in implant-based breast reconstruction. Several investigations have shown increased complications associated with its use. Therefore, the authors' institution placed strict limitations on its use and transitioned to sterile "ready-to-use" acellular dermal ma...

    journal_title:Plastic and reconstructive surgery

    pub_type: 临床试验,杂志文章


    authors: Weichman KE,Wilson SC,Saadeh PB,Hazen A,Levine JP,Choi M,Karp NS

    更新日期:2013-10-01 00:00:00

  • Holoprosencephaly and midline facial anomalies: redefining classification and management.

    abstract::Holoprosencephaly encompasses a series of midline defects of the brain and face. Most cases are associated with severe malformations of the brain which are incompatible with life. At the other end of the spectrum, however, are patients with midline facial defects and normal or near-normal brain development. Although s...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Elias DL,Kawamoto HK Jr,Wilson LF

    更新日期:1992-12-01 00:00:00

  • Facial Nerve Supply to the Orbicularis Oculi around the Lower Eyelid: Anatomy and Its Clinical Implications.

    abstract:BACKGROUND:The motor innervation of the lower orbicularis oculi has not been clearly established. There is a discrepancy between anatomical descriptions and clinical outcomes of the motor innervation of the pretarsal orbicularis oculi muscle. Therefore, the purposes of this study were to identify every motor and sensor...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Choi Y,Kang HG,Nam YS,Kang JG,Kim IB

    更新日期:2017-08-01 00:00:00

  • Bone grafts to the nose in Binder's syndrome (maxillonasal dysplasia): a follow-up of eleven patients with the use of profile roentgenograms.

    abstract::Bone grafts are used to lengthen the dorsum and elevate the tip of the nose in patients with Binder's syndrome. Disappointing long-term results in some patients generally have been assumed to be a result of resorption and/or displacement of the grafts. Treatment outcome was studied in 11 patients with the use of seria...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Rune B,Aberg M

    更新日期:1998-02-01 00:00:00

  • A clinical evaluation of the results of submusculo-aponeurotic dissection and fixation in face lifts.

    abstract::In 25 random patients undergoing rhytidectomy, we did unilateral subplatysmal-fascial dissections of the superficial musculoaponeurotic system (SMAS) of the face and neck--with redistribution of the tension of this system and fixation by suturing. Late evaluation of these patients by 3 observers showed no detectable d...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Rees TD,Aston SJ

    更新日期:1977-12-01 00:00:00

  • A new concept in the tip plasty of Asian rhinoplasty: the flag technique by use of only a septal cartilage.

    abstract:BACKGROUND:To achieve the desired refinements in Asian patients, sufficient septal cartilage is needed for ideal tip projection and lengthening of the nose by the septal extension supported by the stable septum. There are many cases of insufficient septal cartilage in Asian patients. For optimal outcome, the author pro...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章


    authors: Kim CH

    更新日期:2015-04-01 00:00:00