Abstract:
OBJECTIVES:Despite evidence of low representativeness of clinical trial results for depression in adults, the generalizability of clinical trial results for late-life depression is unknown. This study sought to quantify the representativeness of pharmacologic and psychotherapy clinical trial results for late-life unipolar depression. METHOD:Data were derived from the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative sample of 34,653 adults from the United States population. To assess the generalizability of clinical trial results for late-life depression, we applied a standard set of eligibility criteria representative of pharmacologic and psychotherapy clinical trials to all individuals aged 65 years and older in NESARC with a DSM-IV diagnosis of MDE and no lifetime history of mania/hypomania (n = 273) and in a subsample of individuals seeking help for depression (n = 78). RESULTS:More than four of ten respondents and about two of ten respondents would have been excluded by at least one exclusion criterion in a typical pharmacologic and psychotherapy efficacy trial, respectively. Similar results (i.e.41.1% and 25.9%, respectively) were found in the subsample of individuals seeking help for depression. Excess percentage of exclusion in typical pharmacologic studies was accounted for by the criterion "significant medical condition". We also found that populations typically included in pharmacologic and psychotherapy clinical trials for late-life unipolar depression may substantially differ. CONCLUSION:Psychotherapy trial results may be representative of most patients with late-life unipolar depression in routine clinical practice. By contrast, pharmacologic clinical trials may not be readily generalizable to community samples.
journal_name
Aging Ment Healthjournal_title
Aging & mental healthauthors
Hoertel N,Rotenberg L,Schuster JP,Blanco C,Lavaud P,Hanon C,Hozer F,Teruel E,Manetti A,Costemale-Lacoste JF,Seigneurie AS,Limosin Fdoi
10.1080/13607863.2019.1691146subject
Has Abstractpub_date
2021-02-01 00:00:00pages
367-377issue
2eissn
1360-7863issn
1364-6915journal_volume
25pub_type
杂志文章abstract:OBJECTIVES:Despite being identified as a significant clinical phenomenon, wandering of persons with dementia (PWDs) has not been studied in Korea. As an initial trial, various factors chosen from the literature for their predictive relationships to wandering of Korean PWDs were evaluated in this study. METHOD:A total ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860802120821
更新日期:2008-05-01 00:00:00
abstract::Objective: To study the association between vitamin D levels and frailty, its components and course in a depressed sample.Methods: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1515885
更新日期:2020-01-01 00:00:00
abstract::Many healthcare professionals in Hong Kong are now working in dementia care, but little is known about their informational needs in this area. This study explored the level of knowledge about dementia that healthcare professionals perceived themselves as having, and the informational needs of dementia care. 320 respon...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/1360786031000120688
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:In old age, the will-to-live (WTL) is one of the most important indicators of subjective well-being (SWB). However, few studies to date have focused on WTL. In these studies, WTL has mainly been evaluated via indirect questions concerning factors that may influence peoples' WTL, or by measures directed to pa...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2015.1081149
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:Self-perceptions of aging have been shown to predict mental and physical health and even longevity. This study examined the aging perceptions of patients with rheumatic disease and compared them with the general Dutch population. METHODS:Consecutive patients visiting a rheumatology clinic completed the Pers...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2011.651438
更新日期:2012-01-01 00:00:00
abstract::Objectives: Dementia is a growing health priority, particularly in less resourced countries and amongst indigenous populations. Understanding cultural meanings ascribed to dementia is an important aspect of policy development and the provision of culturally congruent care and support for people with dementia, their fa...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1606891
更新日期:2020-08-01 00:00:00
abstract::Objectives: Mentally stimulating leisure activities and cognitive interventions are associated with delayed cognitive decline, although evidence has not been unequivocal, possibly due to differential contribution of the two types of activities. This study aimed to examine the respective contributions of mentally activ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1636204
更新日期:2020-11-01 00:00:00
abstract::Terminally ill cancer patients and their caregivers experience significant difficulties discussing illness and impending death (herein defined as mortality communication). The current study compares response levels as well as patterns of association between mortality communication and psychological distress among care...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860802154473
更新日期:2009-01-01 00:00:00
abstract::Research suggests that the use of creative, artistic activities in later life may positively impact the psychological well-being of older adults. Social robots have been utilized in research with older adults, however, few studies have integrated participatory arts (e.g. theatre) into social robotic platforms for the ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1699016
更新日期:2019-12-18 00:00:00
abstract:OBJECTIVES:The effect of chronic disease status on quality of life (QoL) has been well established. However, less is known about how chronic diseases affect QoL. This article examines impairment in three domains of the WHO International Classification of Functioning, Health and Disability (ICF) - body function, activit...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2014.955457
更新日期:2015-07-01 00:00:00
abstract::International policy initiatives have highlighted the need to include older lesbian, gay, bisexual and transgender (LGBT) issues in the provision of appropriate health and social care. However, empirical studies in the area remain sparse. The aim of this study was to investigate the experiences and needs of LGBT peopl...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2012.751583
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:To adapt the Internalized Stigma of Mental Illness scale (ISMI) to examine self-stigma associated with aging and to study the psychometric properties of this adapted version (IS65+). Finally, self-stigma associated with age in older people is studied. METHOD:The IS65+ was administered to a random sample of ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2016.1247422
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:This study aims to identify the relationship among social functioning, polypharmacy and depression among older patients in Hong Kong. METHOD:Three out of 18 elderly health centres were selected using the cluster sampling method. 457 elders were randomly selected from all the patients aged 65 and over attendi...
journal_title:Aging & mental health
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1080/13607863.2011.562174
更新日期:2011-08-01 00:00:00
abstract::Objective: Both caregivers and the older adults they care for can experience declines in quality of life (QOL) over the course of the dementia trajectory. Little research has examined QOL in African-American caregivers and even less in African-American persons with dementia (PWDs), making it difficult to identify asso...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2020.1711865
更新日期:2020-01-10 00:00:00
abstract::Objectives: The aim of the current study was to assess the associations between dynapenia and the onset and persistence of depression and anxiety among older adults.Methods: This prospective cohort study enrolled community-living older adults (N = 5271; 51.1% females) aged ≥ 50 years (mean age = 63.2, standard deviati...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1699021
更新日期:2019-12-12 00:00:00
abstract:OBJECTIVE:Increased focus on the quality of health care requires tools and information to address and improve quality. One tool to evaluate and report the quality of clinical health services is quality indicators based on a clinical database. METHOD:The Capital Region of Denmark runs a quality database for dementia ev...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2010.508769
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Fear of falling leads to many adverse consequences and may compromise the quality of life of older adults. Psychological factors are potential mediators between the fear of falling and quality of life, but have yet to be explored in detail. This study presents results from examining the mediating effect of t...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2013.805398
更新日期:2013-01-01 00:00:00
abstract::Objectives: Awareness is considered a heterogeneous and non-linear phenomenon in dementia. We aim to investigate patterns of change of different domains of awareness (awareness of cognitive functioning and health condition, activities of daily living, emotional state, social functioning, and relationships) in people w...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1544219
更新日期:2020-05-01 00:00:00
abstract::Studies of older adults' health status and health-related quality of life (HRQoL) often rely on proxy responses when subjects have problems that affect their ability to respond. With the increased interest in outcomes research in health care, it is important to examine proxy reliability on HRQoL instruments. This stud...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860120038357
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:To determine psychotropic drug prescription rates in nursing home residents with dementia and to identify associations with the so far understudied psychosocial non-resident-related factors. METHOD:A cross-sectional, observational, exploratory design as part of PROPER I (PRescription Optimization of Psychot...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2017.1348469
更新日期:2018-09-01 00:00:00
abstract::It is becoming increasingly clear that, in order to better understand the implications of global aging, more cross-cultural research is needed. In the present study, the structure and validity of the Geriatric Depression Scale-Short Form (GDS-SF) was examined in Korean and US samples of older adults. The participants ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860020020618
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVES:Caregivers and clinicians may be confronted with the dilemma whether to allow people in early stages of dementia to go outside independently with the risk of getting lost, or to limit their autonomy and mobility. Newly available technology may offer a solution. This pilot study is focused on the feasibility,...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2011.596810
更新日期:2012-01-01 00:00:00
abstract::The purpose of the present investigation was to examine the impact of speed of processing training on the cognitive and everyday abilities of older adults with initial processing speed or processing difficulty. Participants were randomized to either a speed of processing intervention or a social- and computer-contact ...
journal_title:Aging & mental health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/13607860412331336788
更新日期:2005-05-01 00:00:00
abstract::Objectives: This study aimed to examine the mediating effect of coping strategies on the relationship between family functioning and posttraumatic growth in family caregivers of people with dementia (PwD).Methods: A total of 124 family caregivers of PwD from a memory clinic were investigated from July to October 2017....
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2020.1786800
更新日期:2020-07-07 00:00:00
abstract:OBJECTIVES:In the UK and elsewhere, specialist community mental health teams (CMHTs) are central to the provision of comprehensive services for older people with mental ill health. Recent guidance documents suggest a core set of attributes that such teams should encompass. This article reports on a systematic literatur...
journal_title:Aging & mental health
pub_type: 杂志文章,评审
doi:10.1080/13607863.2011.651431
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To develop a questionnaire assessing vision-targeted health-related quality of life in older adults residing in nursing homes. METHODS:Using content previously identified through structured interviews with nursing home residents, the 57-item Nursing Home Vision-Targeted Health-Related Quality of Life questionn...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860701366186
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Older people with dementia living in care homes often lack appropriate activities. Although homes are expected to offer a range of activities to meet residents' needs, little is known about what makes activities meaningful for people with dementia. This study explores concepts of meaningful activity, as defi...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860802343019
更新日期:2008-09-01 00:00:00
abstract::Objectives: More positive attitudes to aging are associated with better health and wellbeing outcomes. This study examined whether chronological age moderated relationships between attitudes to aging and wellbeing outcomes, and whether these relationships differ according to the specific attitudinal construct measured...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1619167
更新日期:2020-10-01 00:00:00
abstract::This study investigates general and social self-efficacy as possible mediators of the relationship between quantity and quality of social relations and depressive symptomatology. Mediation models were examined using a regionally representative sample of middle-aged (35-59) and older adults (60+). Hierarchical regressi...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860500310690
更新日期:2006-05-01 00:00:00
abstract::This study describes what general practitioners (GPs) tell persons who appear to have dementia and their caregivers after assessment and to estimate the number of (in)correct disclosures and their determinants. In a prospective observational study 64 GPs were instructed to use the Dutch national dementia guideline on ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860500310468
更新日期:2006-03-01 00:00:00