Generalizability of pharmacologic and psychotherapy trial results for late-life unipolar depression.

Abstract:

OBJECTIVES:Despite evidence of low representativeness of clinical trial results for depression in adults, the generalizability of clinical trial results for late-life depression is unknown. This study sought to quantify the representativeness of pharmacologic and psychotherapy clinical trial results for late-life unipolar depression. METHOD:Data were derived from the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a nationally representative sample of 34,653 adults from the United States population. To assess the generalizability of clinical trial results for late-life depression, we applied a standard set of eligibility criteria representative of pharmacologic and psychotherapy clinical trials to all individuals aged 65 years and older in NESARC with a DSM-IV diagnosis of MDE and no lifetime history of mania/hypomania (n = 273) and in a subsample of individuals seeking help for depression (n = 78). RESULTS:More than four of ten respondents and about two of ten respondents would have been excluded by at least one exclusion criterion in a typical pharmacologic and psychotherapy efficacy trial, respectively. Similar results (i.e.41.1% and 25.9%, respectively) were found in the subsample of individuals seeking help for depression. Excess percentage of exclusion in typical pharmacologic studies was accounted for by the criterion "significant medical condition". We also found that populations typically included in pharmacologic and psychotherapy clinical trials for late-life unipolar depression may substantially differ. CONCLUSION:Psychotherapy trial results may be representative of most patients with late-life unipolar depression in routine clinical practice. By contrast, pharmacologic clinical trials may not be readily generalizable to community samples.

journal_name

Aging Ment Health

journal_title

Aging & mental health

authors

Hoertel N,Rotenberg L,Schuster JP,Blanco C,Lavaud P,Hanon C,Hozer F,Teruel E,Manetti A,Costemale-Lacoste JF,Seigneurie AS,Limosin F

doi

10.1080/13607863.2019.1691146

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

367-377

issue

2

eissn

1360-7863

issn

1364-6915

journal_volume

25

pub_type

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