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Ultrasound-defined remission and active disease in rheumatoid arthritis: association with clinical and serologic parameters.

Abstract：

OBJECTIVE:To assess the association of clinical and/or serological parameters with ultrasound-defined disease activity in rheumatoid arthritis (RA). METHODS:Retrospective analysis of 149 consecutive RA patients routinely assessed by sonography of the wrists, metacarpo-phalangeal, and proximal interphalangeal joints. Semiquantitative scoring of synovial hypertrophy/effusion and power Doppler (PD) signals was performed. Sonographic remission was defined by the absence of PD signals. Number of tender and swollen joints, global assessment of disease activity by the physician (VAS-phys) and patient (VAS-pt), C-reactive protein (CRP), erythrocyte sedimentation rate, duration of morning stiffness (MS), simplified disease activity index, disease activity score for 28 joints, clinical disease activity index, and health assessment questionnaires were recorded. RESULTS:PD signals as a sign of active disease were observed in 117 (78.5%) RA patients. CRP, erythrocyte sedimentation rate, and MS were higher in patients with PD signals than in patients in remission. CRP >5.0 mg/L (normal values 0-5.0 mg/L), MS >15 minutes, or the combination of both revealed odds ratios of 5.0, 3.0, or 18.9, respectively, to indicate sonography-defined active disease. The other parameters showed no association with the presence or absence of PD-signals. CONCLUSIONS:Sonography-defined disease activity is associated with CRP and MS, whereas current composite scores and its clinical components did not match this definition.

journal_name

Semin Arthritis Rheum

journal_title

Seminars in arthritis and rheumatism

authors

Dejaco C,Duftner C,Wipfler-Freissmuth E,Weiss H,Graninger WB,Schirmer M

doi

10.1016/j.semarthrit.2011.09.005

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

761-7

issue

6

eissn

0049-0172

issn

1532-866X

pii

S0049-0172(11)00277-0

journal_volume

41

pub_type

杂志文章

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