Malignancy in psoriatic disease: Results from prospective longitudinal cohorts.


OBJECTIVES:To estimate the prevalence and incidence of malignancy and its types in psoriatic arthritis (PsA) and psoriasis without arthritis (PsC) patients, in comparison to the general population, and to identify the predictive factors for developing cancer in psoriatic disease (PsD). METHODS:PsA patients followed prospectively since 1978 and PsC patients followed since 2006 at 6-to-12 month intervals according to a standard protocol were included. Malignancies were recorded prospectively and linkages with Cancer Care Ontario and the Death Registry were carried out to confirm the presence and type of malignancy up to December 2016. Standardized incidence ratios (SIR) were calculated for overall cancers and by age and sex. Cox regression analysis was conducted to identify risk factors associated with the development of malignancy after the diagnosis of PsD. RESULTS:2051 patients (PsD) were included of whom 228 (11%) developed cancer. 168 patients developed cancer after first clinic visit and are included in this report. Overall SIR for malignancy was 0.83 (0.68, 1.00), SIR for females was 1.06 (0.80, 1.37), and for males was 0.67 (0.50, 0.88). The most common malignancies were skin, breast, and hematological. Skin cancer was the only specific cancer that had a higher incidence than the general population with SIR = 3.37 (1.84, 5.66). There was insufficient evidence to suggest an increased risk of malignancy associated with biologics use. CONCLUSIONS:In this long-term prospective follow-up of patients with PsA and PsC the overall malignancy risk was not found to be higher than the general population, while skin cancer increased.


Semin Arthritis Rheum


Polachek A,Muntyanu A,Lee KA,Ye JY,Chandran V,Cook RJ,Gladman DD




Has Abstract


2020-12-24 00:00:00














  • Autosplenectomy and antiphospholipid antibodies in systemic lupus erythematosus: A pathogenetic relationship?

    abstract:OBJECTIVES:To describe a systemic lupus erythematosus (SLE) patient with functional asplenia and antiphospholipid syndrome (APS) and to review the literature to better define its pathogenesis and diagnosis, emphasizing a possible relationship with antiphospholipid antibodies (aPL). METHODS:Descriptive report of 1 case...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Santilli D,Govoni M,Prandini N,Rizzo N,Trotta F

    更新日期:2003-10-01 00:00:00

  • Colchicine as a therapeutic option in periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) syndrome.

    abstract:OBJECTIVE:To evaluate the efficacy of colchicine in reducing the frequency of attacks in patients with PFAPA. STUDY DESIGN:We conducted a 6-month open label, randomized, controlled study among patients with PFAPA who attend the Pediatric Rheumatology Clinic at the Rambam Medical Center in Israel. A total of 18 patient...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Butbul Aviel Y,Tatour S,Gershoni Baruch R,Brik R

    更新日期:2016-02-01 00:00:00

  • A case of bilateral trochleitis in adult-onset Still's disease.

    abstract:OBJECTIVES:We describe the first case of adult-onset Still's disease (AOSD) presenting with trochleitis and successfully treated with an interleukin-1 receptor antagonist. METHODS:This is a descriptive case report of one patient, identified in consultation with the inpatient ophthalmology consult service. RESULTS:A 2...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Gutmark R,Eliasieh K,Rivera-Michlig R

    更新日期:2014-04-01 00:00:00

  • Inverse relationship between preoperative radiographic severity and postoperative pain in patients with osteoarthritis who have undergone total joint arthroplasty.

    abstract:OBJECTIVES:To determine cross-sectionally the influence of risk factors on chronic pain following total joint replacement (TJR) of the knee (TKR) or the hip (THR). METHODS:Eight hundred sixty post-TKR and 928 post-THR patients were studied. Western Ontario and McMaster Osteoarthritis Index pain scores taken on average...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Valdes AM,Doherty SA,Zhang W,Muir KR,Maciewicz RA,Doherty M

    更新日期:2012-02-01 00:00:00

  • Rheumatic disease aspects of leg length inequality.

    abstract::Inequality of leg lengths is associated with low back pain, greater trochanteric bursitis, and degenerative hip disease. The pelvic obliquity that results from a discrepancy of leg lengths may contribute to degenerative changes in the lumbar spine. The diagnosis of leg length inequality may be overlooked. If this occu...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Rothenberg RJ

    更新日期:1988-02-01 00:00:00

  • Serum Bisphenol A is an independent risk factor of hyperuricemia: A 6-year prospective study.

    abstract:OBJECTIVE:This study aims to evaluate whether serum Bisphenol A (BPA) is a risk factor for hyperuricemia. METHODS:In this prospective study, a total of 482 participants without hyperuricemia were enrolled at baseline and followed up for 6 years. Clinical characteristics were recorded, and serum levels of uric acid and...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Hu J,Peng C,Li J,Gao R,Zhang A,Ma L,Zhang L,Yang Y,Cheng Q,Wang Y,Luo T,Wang Z,Qing H,Yang S,Li Q

    更新日期:2019-02-01 00:00:00

  • Physical (in)activity and its influence on disease-related features, physical capacity, and health-related quality of life in a cohort of chronic juvenile dermatomyositis patients.

    abstract:OBJECTIVES:To objectively measure physical activity levels in a cohort of juvenile dermatomyositis (JDM) patients; to compare physical capacity and health-related quality of life in JDM patients and their healthy controls (CTRL) matched by physical activity levels; and to associate physical activity variables with dise...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Pinto AJ,Yazigi Solis M,de Sá Pinto AL,Silva CA,Maluf Elias Sallum A,Roschel H,Gualano B

    更新日期:2016-08-01 00:00:00

  • Association of silica exposure with chest HRCT and clinical characteristics in systemic sclerosis.

    abstract:CONTEXT:Thoracic lymphadenopathy (LA) has been identified as a key prognostic factor in interstitial lung disease (ILD) of all-cause. Crystalline silica is a risk factor of systemic sclerosis (SSc). The association of a history of crystalline silica exposure with chest high-resolution computed tomography (HRCT) feature...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Ballerie A,Cavalin C,Lederlin M,Nicolas A,Garlantézec R,Jouneau S,Lecureur V,Cazalets C,Belhomme N,Paris C,Rosental PA,Jégo P,Lescoat A

    更新日期:2020-10-01 00:00:00

  • Epidemiological aspects of Paget's disease: family history and relationship to other medical conditions.

    abstract::Some epidemiological aspects of Paget's disease were examined using questionnaires completed by 864 patients with physician-diagnosed Paget's disease and 500 controls of similar ages. Specifically studied were issues of familial aggregation of the disorder, history of exposure to certain infectious diseases, other med...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Siris ES

    更新日期:1994-02-01 00:00:00

  • Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus.

    abstract::In the middle of the 20th century, biologists focused on investigating the mechanism of gene regulation and signal transduction in cells, which led to the concept that metabolites were products of gene expression and signal transduction pathways. In the 1920s, the importance of cellular metabolism was shown in the War...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Takeshima Y,Iwasaki Y,Fujio K,Yamamoto K

    更新日期:2019-06-01 00:00:00

  • Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness.

    abstract:OBJECTIVES:To discuss the current terminologies used for fibromyalgia syndrome (FMS) and related overlapping conditions, to examine if central sensitivity syndromes (CSS) is the appropriate nosology for these disorders, and to explore the issue of disease versus illness. METHODS:A literature search was performed throu...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Yunus MB

    更新日期:2008-06-01 00:00:00

  • Mechanoflammation in osteoarthritis pathogenesis.

    abstract::Mechanical injury is the most important risk factor in osteoarthritis (OA) development. Although once considered a passive disease of mechanical attrition, injury drives active mechanosensitive intracellular signalling which affects the structural and symptomatic course of disease. Mechanosensitive signalling in carti...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Vincent TL

    更新日期:2019-12-01 00:00:00

  • Autoantibodies in the diagnosis of systemic rheumatic diseases.

    abstract::Distinct profiles of autoantibodies directed to intracellular antigens can be detected in the systemic connective tissue diseases. They aid in establishing the correct diagnosis and are included in many sets of diagnostic criteria, such as the ones developed for systemic lupus erythematosus (anti-Smith antigen and ant...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: von Mühlen CA,Tan EM

    更新日期:1995-04-01 00:00:00

  • Impact of training on concordance among rheumatologists and dermatologists in the assessment of patients with psoriasis and psoriatic arthritis.

    abstract:OBJECTIVE:To evaluate the impact of training on the reliability among dermatologists and rheumatologists in the assessment of psoriatic arthritis (PsA) patients. METHODS:Overall, 9 hospital-based rheumatologists and 8 hospital-based dermatologists met in Reggio Emilia, Italy on October 2015 to assess 17 PsA patients. ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Salvarani C,Girolomoni G,Di Lernia V,Gisondi P,Tripepi G,Egan CG,Marchesoni A,DREAM study group.

    更新日期:2016-12-01 00:00:00

  • Neurological complications of connective tissue and other "collagen-vascular" diseases.

    abstract::A variety of neurological complications may occur in the various connective tissue and "collagen-vascular" diseases. Most of these complications are due to vasculitis affecting various sites in the central or peripheral nervous system. While the evidence for definitive vasculitis in SLE is not strong, small vessel dam...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Cohen SB,Hurd ER

    更新日期:1981-08-01 00:00:00

  • Clinical and subclinical alveolitis in connective tissue diseases assessed by bronchoalveolar lavage.

    abstract::Subclinical alveolitis, as assessed by bronchoalveolar lavage (BAL) cell analysis, may be present in the lower respiratory tract of a high proportion of symptomless patients with connective tissue diseases (CTDs) with normal chest roentgenograms. The distribution of BAL cell types, mainly macrophages, lymphocytes, and...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Manganelli P,Salaffi F,Pesci A

    更新日期:1997-04-01 00:00:00

  • High prevalence of hypovitaminosis D in Morocco: relationship to lifestyle, physical performance, bone markers, and bone mineral density.

    abstract:OBJECTIVES:We undertook this study to determine the prevalence of hypovitaminosis D, its determinants, and its relationships to physical performance, serum parathyroid hormone (PTH) concentration, bone mineral density, and biochemical markers of bone turnover in healthy, ambulatory, pre- and postmenopausal women. METH...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Allali F,El Aichaoui S,Khazani H,Benyahia B,Saoud B,El Kabbaj S,Bahiri R,Abouqal R,Hajjaj-Hassouni N

    更新日期:2009-06-01 00:00:00

  • Risk profiling for a refractory course of giant cell arteritis: The importance of age and body weight: "Risk profiling for GC resistance in GCA".

    abstract:BACKGROUND:Giant cell arteritis (GCA) is a disease that relapses often, and some patients run a refractory course. Although prompt recognition of resistant GCA is a major issue, there is no well-recognized, baseline risk factor for poor response to glucocorticoid (GC) treatment. METHODS:We included all patients consec...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Liozon E,Dumonteil S,Parreau S,Gondran G,Bezanahary H,Palat S,Ly KH,Fauchais AL

    更新日期:2020-12-01 00:00:00

  • Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system.

    abstract:BACKGROUND:Chondroitin sulfates (CS) are involved in articular metabolism and could be used as therapeutic agents in degenerative articular diseases. OBJECTIVES:To review the published reports describing both the metabolism of glycosaminoglycans (GAG) and their involvement in osteoarticular pathophysiology. METHODS:M...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Bali JP,Cousse H,Neuzil E

    更新日期:2001-08-01 00:00:00

  • Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis.

    abstract:OBJECTIVE:A multidisciplinary expert panel, the Italian board for the TAilored BIOlogic therapy (ITABIO), was constituted to formulate evidence-based decisional statements for the first-line tailored biologic therapy in patient with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). MET...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Cantini F,Niccoli L,Nannini C,Cassarà E,Kaloudi O,Giulio Favalli E,Becciolini A,Biggioggero M,Benucci M,Li Gobbi F,Grossi V,Infantino M,Meacci F,Manfredi M,Guiducci S,Bellando-Randone S,Matucci-Cerinic M,Foti R,Di Gan

    更新日期:2016-04-01 00:00:00

  • Tocilizumab for polymyalgia rheumatica: report of two cases and review of the literature.

    abstract:BACKGROUND:Glucocorticoids (GC) are the mainstay of treatment of polymyalgia rheumatica (PMR). However GC-related adverse events occur frequently, particularly in patients with relapsing disease. Several studies have demonstrated that IL-6 is a key player in the pathogenesis of PMR. OBJECTIVES:To report 2 patients wit...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Macchioni P,Boiardi L,Catanoso M,Pulsatelli L,Pipitone N,Meliconi R,Salvarani C

    更新日期:2013-08-01 00:00:00

  • Long-term clinical and radiological magnetic resonance imaging outcome of abscess-associated spontaneous pyogenic vertebral osteomyelitis under conservative management.

    abstract:OBJECTIVES:Management of abscess-associated spontaneous pyogenic vertebral osteomyelitis (PVO) is controversial. The role of magnetic resonance imaging (MRI) in follow-up and its relation with clinical outcome is often unclear. This study evaluates the clinical and MRI outcome of abscess-associated PVO under conservati...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Euba G,Narváez JA,Nolla JM,Murillo O,Narváez J,Gómez-Vaquero C,Ariza J

    更新日期:2008-08-01 00:00:00

  • Dyslipoproteinemia in the course of active rheumatoid arthritis.

    abstract::Concentrations of serum lipids and serum very low-density lipoproteins and low-density lipoproteins (VLDL+LDL, originally called beta lipoproteins) were measured and agarose gel electrophoresis of serum lipoproteins was performed in 69 patients with active rheumatoid arthritis (RA), 40 patients with psoriatic arthriti...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Lazarevic MB,Vitic J,Mladenovic V,Myones BL,Skosey JL,Swedler WI

    更新日期:1992-12-01 00:00:00

  • Tumor necrosis factor antagonists: different kinetics and/or mechanisms of action may explain differences in the risk for developing granulomatous infection.

    abstract:OBJECTIVE:Tumor necrosis factor (TNF) antagonists fall into 2 classes:etanercept (ETA) is a soluble TNF receptor, while infliximab (INF) and adalimumab (ADA) are monoclonal antibodies against TNF. All 3 drugs are effective in treating rheumatoid arthritis. However, these agents have been associated with an increased ri...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Furst DE,Wallis R,Broder M,Beenhouwer DO

    更新日期:2006-12-01 00:00:00

  • Implementation of treat-to-target in rheumatoid arthritis through a Learning Collaborative: Rationale and design of the TRACTION trial.

    abstract:BACKGROUND/PURPOSE:Treat-to-target (TTT) is a recommended strategy in the management of rheumatoid arthritis (RA), but various data sources suggest that its uptake in routine care in the US is suboptimal. Herein, we describe the design of a randomized controlled trial of a Learning Collaborative to facilitate implement...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,随机对照试验


    authors: Solomon DH,Lee SB,Zak A,Corrigan C,Agosti J,Bitton A,Harrold L,Losina E,Lu B,Pincus T,Radner H,Smolen J,Katz JN,Fraenkel L

    更新日期:2016-08-01 00:00:00

  • Clinical efficacy and safety of denosumab in postmenopausal women with low bone mineral density and osteoporosis: a meta-analysis.

    abstract:OBJECTIVE:Clinical trials indicate that denosumab could be a potential treatment for postmenopausal osteoporosis. The objective of this meta-analysis was to assess the clinical efficacy and safety of offering denosumab to postmenopausal women with low bone mass. METHODS:Data sources included MEDLINE, EMBASE, and Cochr...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,meta分析


    authors: von Keyserlingk C,Hopkins R,Anastasilakis A,Toulis K,Goeree R,Tarride JE,Xie F

    更新日期:2011-10-01 00:00:00

  • Comparing ultraviolet light A photo(chemo)therapy with Methotrexate protocol in childhood localized scleroderma: Evidence from systematic review and meta-analysis approach.

    abstract:OBJECTIVE:Localized scleroderma is a skin fibrosing disorder that, if untreated, may result in severe disability. The purpose of this systematic review is to compare the present evidence concerning the effectiveness of Methotrexate versus phototherapy, alone or associated with Psoralen, in childhood localized scleroder...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,meta分析


    authors: Marrani E,Foeldvari I,Lopez JA,Cimaz R,Simonini G

    更新日期:2018-12-01 00:00:00

  • Incidence of occult cancer in children presenting with musculoskeletal symptoms: a 10-year survey in a pediatric rheumatology unit.

    abstract:OBJECTIVES:To assess the frequency and types of cancer found in children presenting to our Unit with musculoskeletal symptoms over a 10-year period. METHODS:The medical records of patients with musculoskeletal symptoms and a final diagnosis of cancer were reviewed. In each case age, gender, presenting symptoms, labora...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Trapani S,Grisolia F,Simonini G,Calabri GB,Falcini F

    更新日期:2000-06-01 00:00:00

  • Hemodynamic instability in chronic fatigue syndrome: indices and diagnostic significance.

    abstract:OBJECTIVES:To evaluate the cardiovascular response to postural challenge in patients with chronic fatigue syndrome (CFS) and to determine whether the degree of instability of the cardiovascular response may aid in diagnosing CFS. METHODS:Patients with CFS (n = 25) and their age- and gender-matched healthy controls (n ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章


    authors: Naschitz JE,Sabo E,Naschitz S,Shaviv N,Rosner I,Rozenbaum M,Gaitini L,Ahdoot A,Ahdoot M,Priselac RM,Eldar S,Zukerman E,Yeshurun D

    更新日期:2001-12-01 00:00:00

  • Chronic tophaceous gout as the first manifestation of gout in two cases and a review of the literature.

    abstract:OBJECTIVES:Acute gout is a common arthritis that may eventually develop into chronic tophaceous gout (CTG). CTG usually is manifested by recurrent gout attacks. The diagnosis and treatment of CTG is challenging. Although the emergence of CTG without previous gout attacks is uncommon, it is important to recognize this u...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审


    authors: Bieber A,Schlesinger N,Fawaz A,Mader R

    更新日期:2018-06-01 00:00:00