Abstract：
OBJECTIVE:Postoperative cerebrospinal fluid (CSF) leak in neurosurgery remains a significant source of morbidity. TissuePatchDural (TPD), a novel impermeable adhesive membrane, can be used to reinforce dural closure in cases considered at high risk to develop postoperative CSF leak. METHODS:A retrospective, single-center, clinical investigation was conducted on 119 patients who underwent elective neurosurgical procedures between January and June 2010. Inclusion criteria included adult patients undergoing clean elective surgeries where a primary watertight closure was not possible. Three groups of patients were considered: 1) infratentorial, 67 cases; 2) supratentorial, 34 cases; and 3) spinal, 18 cases. All these patients received TPD to reinforce dural closure. Preoperative (long-term corticosteroid therapy, previous surgery and radiotherapy), intraoperative (site of procedures and size of dural gap), and postoperative (early and late hydrocephalus) conditions were analyzed as possible risk factors associated with CSF leakage. RESULTS:The mean follow-up was 7.14 months (range 6-12 months). CSF leak was detected in 11 of 119 cases (9.2%). The presence of pre- and postoperative risk factors was associated with a higher percentage of CSF leakage: 8 of 22 cases (36.3%) vs. 3 of 97 cases (3.1%) (P < 0.0001). All leaks could be conservatively treated and no patient required readmission or second surgery. No TPD-related adverse or allergic effects were observed. CONCLUSIONS:TPD seems to be a safe tool to be used to reinforce dural closure in patients with a high risk of developing CSF leaks.
journal_name
World Neurosurgjournal_title
World neurosurgeryauthors
Ferroli P,Acerbi F,Broggi M,Schiariti M,Albanese E,Tringali G,Franzini A,Broggi Gdoi
10.1016/j.wneu.2011.09.022subject
Has Abstractpub_date
2013-03-01 00:00:00pages
551-7issue
3-4eissn
1878-8750issn
1878-8769pii
S1878-8750(11)01101-6journal_volume
79pub_type
杂志文章abstract：OBJECTIVE:To determine the stability of fusion constructs with unilateral pedicle screw (UPS) or bilateral pedicle screw (BPS) fixation with and without an interbody implant using the lateral lumbar interbody (LLIF) approach. METHODS:Standard nondestructive flexibility tests were performed on 13 cadaveric lumbar speci...
journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2018.02.053
更新日期：2018-05-01 00:00:00
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journal_title：World neurosurgery
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journal_title：World neurosurgery
pub_type： 杂志文章,多中心研究
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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journal_title：World neurosurgery
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journal_title：World neurosurgery
pub_type： 杂志文章
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journal_title：World neurosurgery
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pub_type： 杂志文章
doi：10.1016/j.wneu.2018.01.069
更新日期：2018-04-01 00:00:00
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journal_title：World neurosurgery
pub_type： 历史文章,杂志文章
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更新日期：2017-07-01 00:00:00
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更新日期：2018-07-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2016.08.091
更新日期：2016-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
doi：10.1016/j.wneu.2019.08.134
更新日期：2020-01-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：World neurosurgery
pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
