Abstract:
:Dogs do not appear to progress from obesity-induced insulin resistance to type 2 diabetes mellitus. Both postprandial hyperglycemia and postprandial hypertriglyceridemia have been proposed to cause or maintain beta cell failure and progression to type 2 diabetes mellitus in other species. Postprandial glucose, triglyceride, and insulin concentrations have not been compared in lean and obese dogs. We measured serum glucose, triglyceride, and insulin concentrations in nine naturally occurring obese and nine age- and gender-matched lean dogs. After a 24-h fast, dogs were fed half their calculated daily energy requirement of a standardized diet that provided 37% and 40% of metabolizable energy as carbohydrate and fat, respectively. Fasting and postprandial glucose and triglyceride concentrations were greater in the obese dogs (P < 0.001), although the mean insulin concentration for this group was five times greater than that of the lean group (P < 0.001). Most of the 0.6 mM (11 mg/dL) difference in mean postprandial glucose concentrations between lean and obese dogs was attributable to a subset of persistently hyperglycemic obese dogs with mean postprandial glucose concentrations 1.0 mM (18 mg/dL) greater than that in lean dogs. Persistently hyperglycemic obese dogs had lower triglyceride (P = 0.02 to 0.04) and insulin (P < 0.02) concentrations than other obese dogs. None of the dogs developed clinical signs of diabetes mellitus during follow-up for a median of 2.6 yr. We conclude that pancreatic beta cells in dogs are either not sensitive to toxicity because of mild hyperglycemia or lack another component of the pathophysiology of beta cell failure in type 2 diabetes mellitus.
journal_name
Domest Anim Endocrinoljournal_title
Domestic animal endocrinologyauthors
Verkest KR,Rand JS,Fleeman LM,Morton JMdoi
10.1016/j.domaniend.2011.10.002subject
Has Abstractpub_date
2012-02-01 00:00:00pages
103-12issue
2eissn
0739-7240issn
1879-0054pii
S0739-7240(11)00149-4journal_volume
42pub_type
杂志文章abstract::We have determined the binding affinity and capacity and relative distribution of epidermal growth factor (EGF) receptors in the skin of the Merino sheep fetus before and during the development of the wool follicle population. Autoradiography of tissue sections incubated with [125I]EGF revealed that label was confined...
journal_title:Domestic animal endocrinology
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doi:10.1016/0739-7240(95)00024-9
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abstract::The present study examined, at identical daily nutrient intakes, the impact of separating protein and lactose intakes across two daily meals on the metabolic and endocrine status in heavy veal calves. Calves were assigned to one of six degrees of separating protein and lactose over the two meals (termed nutrient synch...
journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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abstract::The ability of the neurohormone melatonin to ameliorate cryopreservation-induced damage to spermatozoa has been demonstrated in several domestic species. However, it is unclear how these protective effects are conferred, with improvements in sperm quality ambiguously attributed to the general antioxidant activity of m...
journal_title:Domestic animal endocrinology
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doi:10.1016/j.domaniend.2020.106516
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abstract::A remote infusion and blood collection device (Dracpac) was used on free-ranging red deer stags to deliver i.v. a range of ACTH1-24 doses and collect blood for cortisol determination. In Experiment 1, conducted in September, saline and 1, 4, and 16 IU ACTH/100 kg bodyweight were infused (n = 5-7 per treatment). In Exp...
journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2019.03.001
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abstract::The effects of weaning and changing post-weaning diet composition on growth patterns and growth-related hormonal profiles were evaluated in neonatal pigs. Forty-eight crossbred piglets were assigned to two groups (n = 24/group) based on weaning at 2 or 3 wk of age (2W and 3W groups. respectively). At weaning, piglets ...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/s0739-7240(98)00006-x
更新日期:1998-05-01 00:00:00
abstract::Mature Hereford cows (n = 28) were used to determine the effect of percentage body fat on secretion of LH and content of GnRH in the infundibular stalk-median eminence (ISME). Cows were fed to maintain, lose, or gain weight to achieve body condition scores (BCS; 1 = emaciated; 9 = obese) of 3 to 7. Then cows were fed ...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/0739-7240(92)90010-u
更新日期:1992-01-01 00:00:00
abstract::The objective was to evaluate the effects of perinatal dexamethasone (Dex) treatment on postnatal growth in pigs. Experiment 1: 42 piglets were assigned according to birth weight and sex to receive either Dex (1 mg/kg body weight) or sterile saline (Control; equivalent volume) i.m. within 1h of birth. Body weights wer...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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更新日期:2003-04-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2009.05.001
更新日期:2009-10-01 00:00:00
abstract::Relatively little is known about the physiological roles of microRNAs (miRNAs) during follicular development. Previous evidence from in vitro studies suggests specific roles for a subset of miRNAs, including miR-21, miR-23a, miR-145, miR-503, miR-224, miR-383, miR-378, miR-132, and miR-212, in regulating ovarian folli...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2013.06.006
更新日期:2013-10-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
doi:10.1016/s0739-7240(02)00149-2
更新日期:2002-07-01 00:00:00
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journal_title:Domestic animal endocrinology
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更新日期:2010-05-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.domaniend.2004.06.006
更新日期:2004-10-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2016.05.001
更新日期:2016-10-01 00:00:00
abstract::The effects of estrogen and fasting on hepatic metabolism were studied by an arteriovenous difference technique in six multicatheterized ewes. In each experiment samples were collected during fed and 3- and 5-day fasted states before, and 10 to 17 days after the animals had been implanted with 550 mg of estradiol-17 b...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/0739-7240(88)90020-3
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abstract::The experiments were conducted to determine the effects of the administration of growth hormone-releasing peptide-2 (GHRP-2, also named KP102), both orally by gavage and in feed, on the release of growth hormone (GH) in swine and to investigate whether attenuation of the GH response occurs after short-term treatment w...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2010.03.002
更新日期:2010-08-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
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更新日期:1999-10-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2006.07.003
更新日期:2007-11-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2006.05.004
更新日期:2007-08-01 00:00:00
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.domaniend.2005.02.026
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journal_title:Domestic animal endocrinology
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doi:10.1016/j.domaniend.2010.06.004
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journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.domaniend.2012.03.005
更新日期:2012-08-01 00:00:00
abstract::In goats and sheep from the temperate and subtropical latitudes, the breeding season lasts from early autumn to late winter, whereas the anestrous season lasts from late winter to late summer. In prepubertal or postpartum females, the duration of the quiescent period depends mainly on the season of parturition and of ...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.domaniend.2020.106468
更新日期:2020-10-01 00:00:00
abstract::The GH has a multifaceted role in growth, reproduction, and milk production. Nonsynonymous mutations identified as L153V were observed from GH1 (L) to GH2 (V) with higher genotypic frequency for GH1 being 0.87. GH2 (V) allele was identified as a rare allele and the population followed Hardy-Weinberg equilibrium. LL ho...
journal_title:Domestic animal endocrinology
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doi:10.1016/j.domaniend.2019.106405
更新日期:2020-04-01 00:00:00
abstract::Environment enrichment is a rising topic for animal welfare but measures to identify effective enrichment interventions are lacking. In humans and rodent species, environmental enrichment increases brain-derived neurotrophic factor (BDNF), the most abundant neurotrophin in the brain. Higher BDNF concentration is ultim...
journal_title:Domestic animal endocrinology
pub_type: 杂志文章
doi:10.1016/j.domaniend.2018.05.007
更新日期:2018-10-01 00:00:00