Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer.

abstract：:Colorectal cancer is a major cause of cancer deaths in Western countries, but epidemiological data suggest that dietary modification might reduce these by as much as 90%. Cyclo-oxygenase 2 (COX2), an inducible isoform of prostaglandin H synthase, which mediates prostaglandin synthesis during inflammation, and which is...

journal_title：Oncogene

authors： Plummer SM,Holloway KA,Manson MM,Munks RJ,Kaptein A,Farrow S,Howells L

更新日期：1999-10-28 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are known to play an important role in melanoma development and progression. However, the downstream targets of BMPs have not been investigated thus far. Therefore, we treated melanoma cell lines with the Smad-specific BMP inhibitor Dorsomorphin and performed a cDNA microarray. We id...

journal_title：Oncogene

authors： Braig S,Bosserhoff AK

更新日期：2013-02-14 00:00:00

abstract：:CCAAT/enhancer-binding protein-δ (C/EBP-δ), a transcription factor, is elevated in carcinoma compared with that in normal tissue. This study reports a novel function of C/EBP-δ in lymphangiogenesis and tumor metastasis. Genetic deletion of C/EBP-δ in mice resulted in a significant reduction of lymphangiogenesis and pu...

journal_title：Oncogene

authors： Min Y,Ghose S,Boelte K,Li J,Yang L,Lin PC

更新日期：2011-12-08 00:00:00

abstract：:The oncogene EWS-FLI1 encodes a chimeric transcription factor expressed in Ewing's sarcoma family tumors (ESFTs). EWS-FLI1 target gene expression is thought to drive ESFT pathogenesis and, therefore, inhibition of EWS-FLI1 activity holds high therapeutic promise. As the activity of many transcription factors is regula...

journal_title：Oncogene

authors： Bachmaier R,Aryee DN,Jug G,Kauer M,Kreppel M,Lee KA,Kovar H

更新日期：2009-03-05 00:00:00

abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...

journal_title：Oncogene

authors： Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

更新日期：1998-03-26 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...

journal_title：Oncogene

authors： Altieri DC

更新日期：2003-11-24 00:00:00

abstract：:Millions of somatic mutations have recently been discovered in cancer genomes. These mutations in cancer genomes occur due to internal and external mutagenesis forces. Decoding the mutational processes by examining their unique patterns has successfully revealed many known and novel signatures from whole exome data, b...

journal_title：Oncogene

authors： Pei G,Hu R,Dai Y,Zhao Z,Jia P

更新日期：2020-07-01 00:00:00

abstract：:Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by the thiazolidinedione (TZD) class of antidiabetic drugs elicits growth inhibition in a variety of malignant tumors. We clarified the effects of TZDs on growth of human non-small cell lung carcinoma (NSCLC) cells that express endogenous PPAR-gamma...

journal_title：Oncogene

authors： Satoh T,Toyoda M,Hoshino H,Monden T,Yamada M,Shimizu H,Miyamoto K,Mori M

更新日期：2002-03-28 00:00:00

abstract：:Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and as...

journal_title：Oncogene

authors： Angelastro JM,Canoll PD,Kuo J,Weicker M,Costa A,Bruce JN,Greene LA

更新日期：2006-02-09 00:00:00

abstract：:The genes for the M2 subunit of ribonucleotide reductase (RRM2), ornithine decarboxylase (ODC1), and 55,000-Daltons protein (P5), are amplified in hydroxyurea-resistant hamster and human cell lines. These genomic sequences have been mapped to hamster chromosome 7 and to human chromosome 2p24-25 near the cytogenetic lo...

journal_title：Oncogene

authors： Tonin PN,Yeger H,Stallings RL,Srinivasan PR,Lewis WH

更新日期：1989-09-01 00:00:00

abstract：:Oncostatin M (OM) is a polypeptide cytokine that induces autocrine and paracrine effects on AIDS-Kaposi's sarcoma (KS) cells (Nair et al., Science, 255, 1430-1432, 1992; Miles et al., Science, 255, 1432-1434, 1992). The signalling pathways underlying this activation are largely unknown. We have found that OM binding t...

journal_title：Oncogene

authors： Soldi R,Graziani A,Benelli R,Ghigo D,Bosia A,Albini A,Bussolino F

更新日期：1994-08-01 00:00:00

abstract：:Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an...

journal_title：Oncogene

authors： Berthenet K,Bokhari A,Lagrange A,Marcion G,Boudesco C,Causse S,De Thonel A,Svrcek M,Goloudina AR,Dumont S,Hammann A,Biard DS,Demidov ON,Seigneuric R,Duval A,Collura A,Jego G,Garrido C

更新日期：2017-04-20 00:00:00

abstract：:Downregulation of E-cadherin by the transcriptional repressor Snail is associated with acquisition of metastatic potential. Although hepatitis C virus (HCV) core protein has been implicated in hepatocarcinogenesis, it is unclear whether Snail is involved in HCV core-induced dysregulation of E-cadherin. Herein, we inve...

journal_title：Oncogene

authors： Nie D,Shan X,Nie L,Duan Y,Chen Z,Yang Y,Li Z,Tian L,Gao Q,Shan Y,Tang N

更新日期：2016-07-14 00:00:00

abstract：:Although cell invasion is a necessary early step in cancer metastasis, its regulation is not well understood. We have previously shown, in human prostate cancer, that transforming growth factor beta (TGFbeta)-mediated increases in cell invasion are dependent upon activation of the serine/threonine kinase, p38 MAP kina...

journal_title：Oncogene

authors： Xu L,Chen S,Bergan RC

更新日期：2006-05-18 00:00:00

abstract：:In this study we have surveyed by immunoblotting the protein levels of Cyclin D1, D2, D3 and their catalytic partners, Cdk4 and Cdk6 in normal and transformed human cells. We found that all these proteins were differentially expressed in diploid cells derived from different tissues, in contrast to Cyclin E, Cyclin A a...

journal_title：Oncogene

authors： Tam SW,Theodoras AM,Shay JW,Draetta GF,Pagano M

更新日期：1994-09-01 00:00:00

abstract：:The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tube...

journal_title：Oncogene

authors： Rosner M,Freilinger A,Hengstschläger M

更新日期：2007-01-25 00:00:00

abstract：:Nuclear-targeted high molecular weight 24 kDa fibroblast growth factor 2 (FGF-2) may induce specific cell functions through intracrine mechanisms. The role of nuclear FGF-2 on the metastatic potential of carcinoma cells was examined by conditional FGF-2 expression, which demonstrated that spontaneous metastasis in nud...

journal_title：Oncogene

authors： Thomas-Mudge RJ,Okada-Ban M,Vandenbroucke F,Vincent-Salomon A,Girault JM,Thiery JP,Jouanneau J

更新日期：2004-06-10 00:00:00

abstract：:Wilms tumours (WTs) have two distinct types of histology with or without ectopic mesenchymal elements, suggesting that WTs arise from either the mesenchymal or epithelial nephrogenic lineages. Regardless of the presence or absence of CTNNB1 mutations, nuclear accumulation of beta-catenin is often observed in WTs with ...

journal_title：Oncogene

authors： Fukuzawa R,Anaka MR,Weeks RJ,Morison IM,Reeve AE

更新日期：2009-02-26 00:00:00

abstract：:Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men in the western world. Mutations in tumor suppressor genes and in oncogenes are important for PCa progression, whereas the role of stem cell proteins in prostate carcinogenesis is insufficiently examined. This study investigates the role o...

journal_title：Oncogene

authors： Queisser A,Hagedorn S,Wang H,Schaefer T,Konantz M,Alavi S,Deng M,Vogel W,von Mässenhausen A,Kristiansen G,Duensing S,Kirfel J,Lengerke C,Perner S

更新日期：2017-03-01 00:00:00

abstract：:In chronic myelogenous leukemia (CML), the oncogene bcr-abl encodes a dysregulated tyrosine kinase that inhibits apoptosis. We showed previously that human erythroleukemia K562 cells are resistant to antineoplastic drug (taxol)-induced apoptosis through the atypical protein kinase C iota isozyme (PKC iota), a kinase d...

journal_title：Oncogene

authors： Lu Y,Jamieson L,Brasier AR,Fields AP

更新日期：2001-08-09 00:00:00

abstract：:Expression of the c-myc gene is often elevated in human colorectal tumors, but reported amplification of the locus is rare. Here we demonstrate that modest amplification of c-myc is frequently found in aggressive subtypes of colorectal cancer. Careful quantitation of c-myc copy number has shown amplification in 53.8% ...

journal_title：Oncogene

authors： Heerdt BG,Molinas S,Deitch D,Augenlicht LH

更新日期：1991-01-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling is dependent on the heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Activated TbetaRI then mediates TGF-beta signals by inducing the phosphorylation of Smad2 and/or Smad3, which separately hetetorodimerize ...

journal_title：Oncogene

authors： Kleeff J,Ishiwata T,Maruyama H,Friess H,Truong P,Büchler MW,Falb D,Korc M

更新日期：1999-09-23 00:00:00

abstract：:Small-molecule agonists at Toll-like receptor 7 (TLR7) and TLR8 have sparked a vivid interest in cancer research owing to their profound antitumoral activity. The lead compound of the imidazoquinoline family, imiquimod, is marketed as a topical formulation. It is efficacious against many primary skin tumors and cutane...

journal_title：Oncogene

authors： Schön MP,Schön M

更新日期：2008-01-07 00:00:00

abstract：:We have previously shown (Smith et al., 1994) that antibodies raised against the growth arrest and DNA damage inducible protein Gadd45 co-precipitate proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication and repair. Here we demonstrate that Gadd45 can directly bind to PCNA using a Far-wester...

journal_title：Oncogene

authors： Chen IT,Smith ML,O'Connor PM,Fornace AJ Jr

更新日期：1995-11-16 00:00:00

abstract：:Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bladder cancers, possibl...

journal_title：Oncogene

authors： Kondo M,Matsuoka S,Uchida K,Osada H,Nagatake M,Takagi K,Harper JW,Takahashi T,Elledge SJ,Takahashi T

更新日期：1996-03-21 00:00:00

abstract：:Apoptosis resistance is crucially involved in cancer development and progression, represents the leading cause for failure of anticancer therapy and is caused, for example, by downregulation of proapoptotic intracellular signaling molecules such as caspase-8. We found that the cytotoxic drugs methotrexate (MTX) and 5-...

journal_title：Oncogene

authors： Ehrhardt H,Häcker S,Wittmann S,Maurer M,Borkhardt A,Toloczko A,Debatin KM,Fulda S,Jeremias I

更新日期：2008-01-31 00:00:00

abstract：:Rho small GTP-binding protein regulates various cell functions, such as formation of stress fibers and focal adhesions, cell motility, membrane ruffling, cytokinesis and smooth muscle contraction in mammalian cells and bud formation in the yeast Saccharomyces cerevisiae. As to the functioning sites of Rho in Saccharom...

journal_title：Oncogene

authors： Takaishi K,Sasaki T,Kameyama T,Tsukita S,Tsukita S,Takai Y

更新日期：1995-07-06 00:00:00

abstract：:Homozygous mutations of the recessive oncogene lethal-(2) giant larvae (l(2)gl) of Drosophila melanogaster cause lethal neoplasms of the imaginal discs and the brain hemisphere. A 13-kb DNA segment spanning the l(2)gl+ locus has been inserted into P element vectors and used for P-mediated transformation. The P-l(2)gl+...

journal_title：Oncogene

authors： Opper M,Schuler G,Mechler BM

更新日期：1987-05-01 00:00:00

abstract：:The cbl oncogene was first identified as part of a transforming retrovirus which arose in a mouse pre-B cell lymphoma. Its protein product, p120cbl, is cytoplasmic and has several distinctive domains including a highly basic region, a RING finger motif and a large proline-rich domain. A mutation to cbl in the 70Z/3 pr...

journal_title：Oncogene

authors： Bowtell DD,Langdon WY

更新日期：1995-10-19 00:00:00

abstract：:p27Kip1 plays an important role in cell cycle progression by negatively regulating the activity of cyclin-Cdk complexes. To understand how p27Kip1 functions, the level and subcellular location of p27Kip1 in Swiss/3T3 cells following serum stimulation of quiescent cells was examined. Surprisingly, p27Kip1 was observed ...

journal_title：Oncogene

authors： Wang G,Miskimins R,Miskimins WK

更新日期：1999-09-16 00:00:00